Kevin Harding - Niskayuna NY, US Jianming Zheng - Shanghai, CN Yongqing Li - Ann Arbor MI, US Ming Jia - Shanghai, CN Guiju Song - Shanghai, CN Joseph Ross - Cincinnati OH, US Ralph Isaacs - Cincinnati OH, US
International Classification:
G01B 11/24
US Classification:
702167000
Abstract:
A computer-implemented method, system, and computer program code are provided for characterizing an edge break, e.g., part features and/or geometric discontinuities that could give rise to edge sharpness, as may be encountered in a chamfer, bevel, fillet and other part features. The methodology enables to accurately and consistently determine in a manufacturing setting, for example, any applicable geometric parameter for characterizing the edge break.
Hasan B. Alam - Natick MA, US Yongqing Li - West Roxbury MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
International Classification:
G01N 33/68
US Classification:
435 74, 435 792, 435 23
Abstract:
Methods for the use of keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) (KC/GRO), apolipoprotein A2 (APOA2), angiotensinogen r (AGT), thyroglobulin (TG), disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), anionic trypsin-1 (PRSS1), complement C4 (C4A), zona pellucida sperm-binding protein 1 (ZP1), neuropilin-2 (NRP2), solute carrier family 13 member 2 (SLC13A2), glucagon-like peptide 2 receptor (GLP2R), lipoma high mobility group protein isoform I-C (HMGIC) fusion partner-like protein 4 (LHFPL4), and claudin-3 (CLDN3) as biomarkers for diagnosis and prognosis, and for monitoring the efficacy of treatment, in hemorrhagic shock (HS).
Methods of diagnosing sepsis, severe sepsis, or septic shock and predicting prognosis in subjects with septic shock, based on levels of citrullinated histone H3 (Cit H3) in the subject, e.g., in a sample comprising serum (e.g., whole blood, serum, or plasma), cerebrospinal fluid, urine, saliva, or peritoneal fluid from the subject.
Valproic Acid For Treatment Of Myocardial Ischemia
Provided herein are pharmaceutical compositions comprising valproic acid and methods of use thereof for the treatment and/or prevention of myocardial ischemia and/or infarction.
The technology described herein is directed to the treatment of sepsis and/or septic shock by, e.g. administering an agent that can reduce the level of circulating citrullated histones.