Young Joon Kwon

US Patent:

8318156, Nov 27, 2012

Filed:

Jul 10, 2007

Appl. No.:

12/373510

Inventors:

Donald W Landry - New York NY, US
Joanne MacDonald - New York NY, US
Daquan Gao - Louisville KY, US
James H. Woods - Ann Arbor MI, US
Roger K. Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 38/46
A61K 38/43
C12N 9/16
C12N 9/14
C12P 21/06
C12P 19/34
C07H 21/04

US Classification:

424 946, 424 941, 435196, 435195, 435 691, 435 911, 536 231, 536 232, 530350

Abstract:

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

US Patent:

20130136728, May 30, 2013

Filed:

Nov 14, 2012

Appl. No.:

13/676324

Inventors:

The Trustees of Columbia University in the City of - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US
Daquan Gao - Louisville KY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 9/18

US Classification:

424 946, 536 232, 435197

Abstract:

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

US Patent:

54807069, Jan 2, 1996

Filed:

Jun 16, 1994

Appl. No.:

8/260661

Inventors:

Hsin L. Li - Parsippany NJ
Young D. Kwon - Mendham NJ
Dusan C. Prevorsek - Morristown NJ

Assignee:

AlliedSignal Inc. - Morris Township NJ

International Classification:

B32B 512
B32B 700
B27N 900

US Classification:

428113

Abstract:

This invention relates to a fire resistant multilayer complex ballistic resistant article comprising at least one first layer comprised a plurality of flammable fibers a first matrix and at least one second layer which is adjacent to said first layer which comprises a plurality of fire resistant fibers in a second matrix, wherein the second matrix comprises a fire retardant material and is different from the first matrix material.

US Patent:

50063901, Apr 9, 1991

Filed:

Jun 19, 1989

Appl. No.:

7/367642

Inventors:

Sheldon Kavesh - Whippany NJ
Kwang Kim - Seoul, KR
Young D. Kwon - Morristown NJ
Dusan C. Prevorsek - Morristown NJ

Assignee:

Allied-Signal - Morris Township, Morris County NJ

International Classification:

B32B 508,12
B32B 2702

US Classification:

428105

Abstract:

The present invention relates to high strength, high modulus polyethylene filaments which form composites having improved shear strength and composites formed from said filaments.

US Patent:

53956915, Mar 7, 1995

Filed:

Mar 8, 1993

Appl. No.:

8/028735

Inventors:

Sheldon Kavesh - Whippany NJ
Kwang Kim - Seoul, KR
Young D. Kwon - Morristown NJ
Dusan C. Prevorsek - Morristown NJ

Assignee:

AlliedSignal Inc. - Morris Township, Morris County NJ

International Classification:

B32B 508
B32B 512

US Classification:

428357

Abstract:

The present invention relates to high strength, high modulus polyethylene filaments which form composites having improved shear strength and composites formed from said filaments.

US Patent:

20220183698, Jun 16, 2022

Filed:

Jan 31, 2020

Appl. No.:

17/425539

Inventors:

- New York NY, US
Kurt YAEGER - New York NY, US
Anthony COSTA - New York NY, US
Thomas OXLEY - New York NY, US
Alejandro BERENSTEIN - New York NY, US
Young Joon KWON - New York NY, US
Joe BORRELLO - New York NY, US

International Classification:

A61B 17/12
A61M 25/10
A61M 25/00
A61L 24/06

Abstract:

A detachable tip sheathed balloon microcatheter is provided for delivering an embolic agent to a target location for the embolization of an arteriovenous malformation (AVM). The detachable tip sheathed balloon microcatheter including a balloon microcatheter including a first shaft and an inflatable balloon that is coupled to a distal end portion of the first shaft; and a detachable tip assembly that is configured to be detachably coupled to the first shaft of the balloon microcatheter. The detachable tip assembly includes a protective balloon sheath that is coupled to a proximal end portion of the second shaft, wherein when the detachable tip assembly is coupled to the balloon microcatheter, the protective balloon sheath surrounds at least a portion of the inflatable balloon.

US Patent:

20200231571, Jul 23, 2020

Filed:

Aug 23, 2016

Appl. No.:

15/755009

Inventors:

- New York NY, US
Francesca Curreli - Bronx NY, US
Peter D. Kwong - Bethesda MD, US
Young Do Kwon - Bethesda MD, US

International Classification:

C07D 403/12
A61P 31/18
C07D 413/12
C07D 207/34
C07D 241/04
C07D 405/14
C07D 417/14
C07D 401/14
C07D 417/12

Abstract:

Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.

US Patent:

20160160195, Jun 9, 2016

Filed:

Nov 30, 2015

Appl. No.:

14/954813

Inventors:

Donald Landry - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US
Daquan Gao - Louisville KY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
The University of Kentucky Research Foundation - Lexington KY

International Classification:

C12N 9/18
A61K 38/46

Abstract:

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.