Yu U Chen

US Patent:

20230116783, Apr 13, 2023

Filed:

Feb 8, 2021

Appl. No.:

17/798041

Inventors:

- Tampa FL, US
Stephen Bryant LIGGETT - Treasure Island FL, US
David E. KANG - Wesley Chapel FL, US
Yu CHEN - Tampa FL, US
Eric LEWANDOWSKI - Tampa FL, US

International Classification:

A61K 38/17
A61P 25/28
A61K 31/437
A61K 31/496
A61K 31/42

Abstract:

As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein.

US Patent:

20200295379, Sep 17, 2020

Filed:

Jul 19, 2017

Appl. No.:

16/318246

Inventors:

- Atlanta GA, US
- Lawrence KS, US
Yu Chen - Atlanta GA, US
Ben Deglee - Atlanta GA, US
Brian Doyle - Atlanta GA, US
Franklin Tao - Lawrence KS, US
Lei Zhang - Atlanta GA, US

International Classification:

H01M 4/86
H01M 4/90
H01M 8/0637
H01M 8/1253
H01M 8/126

Abstract:

A solid oxide fuel cell capable of directly utilizing hydrocarbons as a fuel source at operating temperatures between 200 C. and 500 C. The anode, electrolyte, and cathode of the solid oxide fuel cell can include technologies for improved operation at temperatures between 200 C. and 500 C. The anode can include technologies for improved direct utilization of hydrocarbon fuel sources.