Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.
Sanford Simon - New York NY, US Yu Chen - New York NY, US
International Classification:
A01K 67/027
US Classification:
800006000, 800014000
Abstract:
Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.
Animals, Cells And Methods For Production Of Detectably-Labeled Antibodies
Sanford M. Simon - New York NY, US Yu Chen - New York NY, US
International Classification:
A01K 67/027 C12N 15/85 C12N 5/06 C07K 16/18
US Classification:
800 6, 800 14, 435328, 5303917
Abstract:
Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.
Methods Of Identifying Modulators Of The Estrogen Receptor
Sanford M. Simon - New York NY Melvin S. Schindler - Okemos MI Yu Chen - New York NY
Assignee:
Board of Trustees Operating Michigan State University - East Lansing MI
International Classification:
G01N 3122 G01N 2180 G01N 3348 C07C21104
US Classification:
436163
Abstract:
The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have the pharmaceutical effect of tamoxifen without the corresponding side-effects.
Novel Isoform Of Anaplastic Lymphoma Kinase And Its Uses
The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.
System And Method For Acquiring Both T2*-Weighted And T1-Weighted Data In A Single Acquisition Using A Single Dose Of Contrast Agent
Described here are systems and methods for obtaining measurements of both tissue perfusion and permeability with a magnetic resonance imaging (“MRI”) system after the administration of a single dose of contrast agent. To this end, the MRI system is directed to acquire T2-weighted or T2*-weighted data, during which the acquired signal values are monitored for a trigger event. When the trigger event occurs, the MRI system is directed to switch from acquiring the T2-weighted or T2*-weighted data to acquiring T1-weighted data. The systems and methods described here can thus be used for a fully automated, single acquisition of perfusion and permeability measurements using only a single dose of contrast agent.
Novel Isoform Of Anaplastic Lymphoma Kinase And Its Uses
The present invention relates to a runcated isoform of naplastic ymphoma inase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.
Sep 2014 to 2000 Mandarin Chinese TeacherSuder Montessori Magnet
Mar 2014 to May 2014Saint Sylvester
Sep 2013 to Mar 2014Multilingual Connections Chicago, IL Jun 2013 to Mar 2014 Mandarin Chinese TeacherMandarin Chinese Center Chicago, IL Jun 2013 to Mar 2014 Mandarin Chinese TeacherAfter School Programs at Saint John Berchmans
Sep 2013 to Nov 2013Mandarin Garden
Sep 2011 to Nov 2011 Mandarin Chinese Teacher
Education:
Kent State University Kent, OH Jun 2011 Master of ArtsShanghai International Studies University Jun 2010 Bachelor of Arts in International Business ManagementInternational Summer Institute for Business Management Jun 2008University of Victoria Victoria, BC
Jun 2012 to Jun 2012 Postdoctoral AssociateWayne State University
Sep 2005 to May 2012 Research AssistantUniversity of Windsor
Sep 2003 to Aug 2005 Research AssistantShenyang Research Institute of Chemical Industry
Aug 2002 to Aug 2003 Assistant Engineer
Education:
Wayne State University Detroit, MI Sep 2005 to May 2012 Ph. D. in Analytical ChemistryUniversity of Windsor 2003 to 2005 M.S in Physical ChemistryDalian University of Technology Dalian, CN 1998 to 2002 B.Eng in Applied Chemistry
Skills:
1. In-depth knowledge and hands-on experience in identification, characterization, and quantification of small molecules and proteins using mass spectrometry 2. Adept at top-down (middle-down) MS/MS analysis of protein post-translational modifications, using CID, ECD, ETD, and IRMPD techniques for protein fragmentation, and database searching for PTM mapping 3. Hands-on experience in sample preparation, including cell growth, harvesting, digestion, and peptide/protein separation using RP-HPLC, nano-LC, and HILIC 4. Practical knowledge H/D exchange for protein structure elucidation 5. Extensive experience in development of electrospray ionization (ESI), ion funnel, multiple ion trap (quadrupole, hexapole, and octopole ) 6. Expertise in Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) 7. Hands-on experience in SIMION 8.0 simulation and Auto CAD, Autodesk Inventor software for instrument development 8. In-depth knowledge of computational chemistry/ electronic structure calculations and gas phase thermochemistry
XtraMedium Communications Group Chicago, IL Jan 2013 to Apr 2013 Project AssistantStandard Chartered Bank Shenzhen, CN Sep 2011 to Oct 2011 InternShenzhen Development Bank Shenzhen, CN Jul 2011 to Aug 2011 Intern
Education:
Illinois Institute of Technology, Stuart School of Business Chicago, IL 2012 to 2014 Masters of Science in Finance - Financial Engineering & ProgrammingShenzhen University Shenzhen, CN 2008 to 2012 B.S. in Finance
Skills:
C++, C#, Python, Matlab, VBA, SQL, XML, ADO.net, Microsoft Word, Excel, Access, Linux;
Wolters Kluwer New York, NY Jul 2014 to Dec 2014 Data Analyst (Contract)Harbin Institute of Technology
Jan 2011 to Apr 2014 Ph.D. StudentCity University of New York New York, NY Sep 2011 to Jul 2012 Visiting StudentThe Hongkong Polytechnic University
Jul 2010 to Dec 2010 Research AssistantHarbin Institute of Technology
Jun 2007 to Jun 2008 Master StudentHarbin Institute of Technology
Sep 2006 to Jun 2007 Master Student
Education:
Harbin Institute of Technology Sep 2008 to Apr 2014 Ph.D. in Computer Science & TechnologyHarbin Institute of Technology Sep 2006 to Jul 2008 Master of Engineering in Engineering MechanicsHarbin Institute of Technology Sep 2002 to Jul 2006 Bachelor of Engineering in Computer Science & Technology
Skills:
Natural Language Processing, Information Extraction, Data Mining, Machine Learning
DePaul University Chicago, IL 2014 to 2015 Master of Science in FinanceUniversity of Fraser valley Abbotsford, BC 2009 to 2013 Bachelor of Business Administration in Finance,Accounting
Boston University ECE Department Boston, MA Jan 2010 to May 2012 Office AssistantWTBU Boston, MA Sep 2009 to May 2012 Intern/On Air DJ/Street Team CoordinatorHorizon's Enrichment Program Brooklyn, NY Jul 2009 to Aug 2011 TeacherIntrepid Sea, Air & Space Museum New York, NY Jul 2010 to Aug 2010 Intern
Education:
Boston University Boston, MA 2012 Bachelor of Arts in Political Science
Skills:
MS Office: Excel, PowerPoint, Word, Outlook, Web Design: Basic HTML, CSS, WordPress, Photoshop, Language: Proficient in Taishanese
The University of New Mexico Albuquerque, NM 2011 to 2011 Co-instructorSt. Pius X High School Albuquerque, NM 2011 to 2011 Private ESL tutor of two Chinese studentsThe University of New Mexico Albuquerque, NM 2008 to 2011 Judge of debatesThe University of New Mexico Albuquerque, NM 2010 to 2010 Private ESL tutor of a Taiwanese adult ELL learnerThe University of New Mexico
2008 to 2009 Judge for CELAC intermediate and advanced ESL class debatesOriental Institute of Technology
2002 to 2008 Full-time English InstructorOriental Institute of Technology
2006 to 2006 Coordinator of the Division of EnglishOriental Institute of Technology
2006 to 2006 Coordinator of the Study English Abroad ProgramEducation First English Language School Taipei
2005 to 2005 English teacher/escortOriental Institute of Technology
2001 to 2002 Part-time English InstructorLung Hwa University
2001 to 2002 Part-time English InstructorNational Defense Management College Taipei
2001 to 2002 Part-time English InstructorIDEAR Knowledge Networks Corp
2001 to 2001 English Instructor and R&DYuan Ze University
2000 to 2001 English Instructor and R&DAlbuquerque Chinese School Albuquerque, NM 1997 to 1998 Chinese Teacher
Education:
The University of New Mexico Albuquerque, NM 2008 Ph. D. in TESOL and special educationNew York University New York, NY 1999 to 2000 M.A. in Teaching and LearningThe University of New Mexico Albuquerque, NM 1995 to 1999 B.A. in Secondary Education
May 2009 to Present Research AssistantUniversity of Illinois at Chicago
Aug 2012 to Dec 2012 Student InstructorIntermediate Macroeconomics
Aug 2012 to Dec 2012 Teaching Assistant, UICBMO Harris Bank Chicago, IL May 2012 to Aug 2012 InternThe Chicago Project for Violence Prevention, Center for the Advancement of Distance Education, UIC School of Public Health
Jun 2011 to Aug 2011 Research AssistantUIC
Jan 2008 to Jul 2008 Research Assistant for Prof. Lawrence OfficerInvestment Banking Zhejiang Business Headquarters, Guangfa Securities Co., Ltd.
Nov 2005 to May 2006 Intern
Education:
Zhejiang University Jun 2006 M.A. in FinanceZhejiang University Jun 2004 B.A. in FinanceUniversity of Illinois at Chicago Chicago, IL Ph.D. in Economics
Skills:
SAS, STATA, Eviews, RATS, SQL, AQT, Microsoft Word, Excel, Power Point, Outlook, Mandarin
Montefiore Medical Center Physical Medicine 111 E 210 St STE G78, Bronx, NY 10467 7189204133 (phone), 7189202289 (fax)
Childrens Physicians Of Westchester 4350 Van Cortlandt Park E, Bronx, NY 10470 3472266437 (phone), 3472266438 (fax)
John A Coleman School 317 North St, White Plains, NY 10605 9145974071 (phone), 9143971765 (fax)
Education:
Medical School China Med Univ, Shenyang City, Liaoning, China Graduated: 1988
Procedures:
Neurological Testing Physical Medicine and Rehabilitation, Tests and Measurements Physical Therapy Evaluation
Languages:
English Spanish
Description:
Dr. Chen graduated from the China Med Univ, Shenyang City, Liaoning, China in 1988. She works in White Plains, NY and 2 other locations and specializes in Physical Medicine & Rehabilitation. Dr. Chen is affiliated with Montefiore Medical Center and Westchester Medical Center.
Dr. Chen graduated from the Taipei Med Coll, Taipei, Taiwan (385 04 Prior 1/71) in 1979. He works in Anaheim, CA and specializes in Family Medicine. Dr. Chen is affiliated with Kaiser Permanente Orange County Anaheim Medical Center.
Rush University Cancer Center 1725 W Harrison St STE 1010, Chicago, IL 60612 3129425904 (phone), 3129423192 (fax)
Education:
Medical School Albert Einstein College of Medicine at Yeshiva University Graduated: 2010
Languages:
English Polish Spanish
Description:
Dr. Chen graduated from the Albert Einstein College of Medicine at Yeshiva University in 2010. She works in Chicago, IL and specializes in Radiation Oncology. Dr. Chen is affiliated with Rush University Medical Center.