Yu R Chen

US Patent:

6406861, Jun 18, 2002

Filed:

Oct 6, 1999

Appl. No.:

09/413044

Inventors:

Daniel R. Henderson - Palo Alto CA
Yu Chen - Sunnyvale CA
De Chao Yu - Foster City CA

Assignee:

Cell Genesys, Inc. - Foster City CA

International Classification:

G01N 3353

US Classification:

435 71, 4241401, 4242331, 4241311, 4241591, 4242781, 424 931, 530351, 514885

Abstract:

Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic therapeutic agent are selectively removed from the blood of an individual prior to administration of the viral immunogenic therapeutic agent by reaction extracorporeally with an immunosorbent which specifically binds the antibody. After the antibody is selectively removed from the blood, the blood is reinfused into the patient and the viral immunogenic therapeutic agent is administered. The invention also provides kits and compositions for selective removal of anti-viral antibody.

US Patent:

6548893, Apr 15, 2003

Filed:

Jul 3, 2001

Appl. No.:

09/898567

Inventors:

Yu Ju Chen - San Ramon CA
Hui Wu - Milpitas CA

Assignee:

BigBear Networks, Inc. - Milpitas CA

International Classification:

H01L 2312

US Classification:

257704, 257693, 257710, 257728

Abstract:

An apparatus and method for hermetically sealing, EMI shielding integrated circuits for high-speed electronic devices using a combination of microstrip to buried stripline interface for signal transmission from the integrated circuit. The packaging provided comprises a first plurality of microstrips interconnecting the integrated circuit to a plurality of buried striplines exposed on a surface of the main substrate. A ceramic interposer placed over the main substrate âburiesâ a portion of the exposed striplines on the main substrate to thereby insulate these signal paths from a hermetically sealing, and EMI shielding metal lid placed over the integrated circuit. The metal lid and the seal ring brazed over the ceramic interposer thus provide both a hermetic seal and an electric radiation block. A reduction in dispersion due to the buried striplines is also achieved, as well as improving jitter performance.

US Patent:

6697260, Feb 24, 2004

Filed:

Oct 29, 2001

Appl. No.:

10/040421

Inventors:

Yu Ju Chen - San Ramon CA
Thomas J. Sleboda - Milpitas CA
Michael Zhong Xuan Wong - Milpitas CA
Hui Wu - Milpitas CA

Assignee:

Big Bear Networks, Inc. - Milpitas CA

International Classification:

H05K 500

US Classification:

361752, 361753, 361736, 361735, 361785, 361803, 361796

Abstract:

An integrated high-speed package comprising a package housing having a housing lip and connector having a center pin abutting along a bottom surface of the housing lip. For signal registration of a first substrate to the signal lead, the substrate is âfloatedâ up to the housing lip, which provides an alignment reference to ensure that the top surface of the first substrate is aligned and in direct registration with the signal lead. In another embodiment, the center pin to substrate registration is provided at a top surface of a housing base. The housing base preferably comprises a first portion of a first height and a second portion of a second height. Accordingly, the housing base can accommodate substrates of different thickness while allowing a top surface of the first and a second substrate to be coplanar to facilitate signal registration there between.

US Patent:

7673143, Mar 2, 2010

Filed:

Feb 24, 2004

Appl. No.:

10/786345

Inventors:

William J. Yeager - Menlo Park CA, US
Yu Chen - San Jose CA, US
Brian K. Raymor - Arlington VA, US
Jackson Wong - Menlo Park CA, US

Assignee:

Sun Microsystems, Inc. - Menlo Park CA

International Classification:

H04L 9/32

US Classification:

713175, 713153, 713168

Abstract:

A method for securing a communication between a peer node and an intermediary peer node in a peer-to-peer network comprises the peer node generating a secured communication request to the intermediary peer node. The intermediary peer node authenticates the peer node in response to the secured communication request. The intermediary peer node issues a signed certificate of authority upon successful authentication.

US Patent:

20230116783, Apr 13, 2023

Filed:

Feb 8, 2021

Appl. No.:

17/798041

Inventors:

- Tampa FL, US
Stephen Bryant LIGGETT - Treasure Island FL, US
David E. KANG - Wesley Chapel FL, US
Yu CHEN - Tampa FL, US
Eric LEWANDOWSKI - Tampa FL, US

International Classification:

A61K 38/17
A61P 25/28
A61K 31/437
A61K 31/496
A61K 31/42

Abstract:

As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein.

US Patent:

20210149874, May 20, 2021

Filed:

Jan 30, 2020

Appl. No.:

16/777858

Inventors:

- San Francisco CA, US
Yvonne Zhou - San Francisco CA, US
Yu Chen - Bellevue WA, US
Shivan Kaul Sahib - Vancouver, CA

Assignee:

salesforce.com, inc. - San Francisco US

International Classification:

G06F 16/23
G06Q 10/10

Abstract:

Implementations retrieve a first event that published to a first source of events responsive to updating, deleting, or inserting a first record in a database object that stores records relating to consent. The first event is processed. Processing the first event includes storing in an attribute of a second event an identifier for a second record that relates to the first record and that is in a second database object that stores records relating to consent. If the first record was inserted or updated, processing the first event includes storing in an attribute of the second event one or more identifiers and respective values of fields of the first record based on attributes of the first event.

US Patent:

20210115133, Apr 22, 2021

Filed:

Aug 28, 2020

Appl. No.:

17/005675

Inventors:

- South San Francisco CA, US
Betty Chan Li - Millbrae CA, US
Yu Chen - Foster City CA, US
Taruna Arora - Palo Alto CA, US
Hugo Matern - San Mateo CA, US
Wenyan Shen - Redwood City CA, US

International Classification:

C07K 16/28
A61K 39/00

Abstract:

The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.

US Patent:

20210030857, Feb 4, 2021

Filed:

Jul 14, 2020

Appl. No.:

16/928862

Inventors:

- South San Francisco CA, US
Betty Chan Li - Millbrae CA, US
Yu Chen - Foster City CA, US
Taruna Arora - Palo Alto CA, US
Hugo Matern - San Mateo CA, US
Wenyan Shen - Redwood City CA, US

International Classification:

A61K 39/00
C07K 16/28

Abstract:

The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.

Address:

4602 E Linebaugh Ave, Temple Terrace, FL 33617

VIN:

1J8FT47W47D143208

Make:

JEEP

Model:

COMPASS

Year:

2007