Yu Chen

US Patent:

20230116783, Apr 13, 2023

Filed:

Feb 8, 2021

Appl. No.:

17/798041

Inventors:

- Tampa FL, US
Stephen Bryant LIGGETT - Treasure Island FL, US
David E. KANG - Wesley Chapel FL, US
Yu CHEN - Tampa FL, US
Eric LEWANDOWSKI - Tampa FL, US

International Classification:

A61K 38/17
A61P 25/28
A61K 31/437
A61K 31/496
A61K 31/42

Abstract:

As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein.

US Patent:

20210348119, Nov 11, 2021

Filed:

Oct 11, 2019

Appl. No.:

17/284215

Inventors:

- Rockville MD, US
Yu CHEN - Rockville MD, US
Anton SIMEONOV - Rockville MD, US

Assignee:

The United States of America as Represented By The Secretary of The Department of Health and Human - Rockville MD

International Classification:

C12N 5/00

Abstract:

Compositions and methods useful for culturing mammalian cells, tissues and/or organs are provided. The compositions contain Chroman 1 or its derivatives, may further include Emricasan or its derivatives, and may further include one or both of trans-ISRIB and polyamines. The compositions may be formulated as media additives, media concentrates or working media. The compositions and methods may be used to culture stem cells, progenitor cells, differentiated cells, isolated primary cells, secondary cells, immortalized cells, cell line cells, germline cells, somatic cells, or modified cells, including genetically modified cells. The compositions and methods may be used to culture, preserve or maintain cells, tissues, organs parts or organs, grow embryoid bodies, embryos, organs or organ parts.

US Patent:

20190167116, Jun 6, 2019

Filed:

Nov 15, 2018

Appl. No.:

16/192229

Inventors:

Yu Chen - College Park MD, US
Qinggong Tang - College Park MD, US
Udayakumar Kanniyappan - Hyattsville MD, US
Lin Z. Li - Aston PA, US
He Xu - Lansdowne PA, US
Yi Liu - College Park MD, US
Emily Conant - Philadelphia PA, US

International Classification:

A61B 5/00
A61B 1/07
A61B 1/04
A61B 1/06
A61B 1/00
A61B 10/02

Abstract:

In accordance with aspects of the present disclosure, an exemplary system includes a hollow probe having a lumen containing one or more excitation optical fiber(s) and one or more imaging optical fiber(s) where the probe is sized to access a person's body, a first light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of NADH in breast tissue, a second light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of FAD in tissue such as breast tissue, an image capturing device optically coupled to the imaging fiber(s), and a controller configured to control the first light source and the image capturing device to capture NADH fluorescence signals/intensities while the probe is within the person's body and control the second light source and the image capturing device to capture FAD fluorescence signals/intensities while the probe is within the person's body.

US Patent:

20180250266, Sep 6, 2018

Filed:

Nov 24, 2017

Appl. No.:

15/821984

Inventors:

- Seoul, KR
MINYOUNG KIM - Incheon, KR
Youngsu LIM - Jeollabuk-do, KR
DAEHYUN HA - Seoul, KR
Young Yiul LEE - Seoul, KR
Buom Yong RYU - Gyeonggi-do, KR
Vladimir Uversky - Tampa FL, US
Insung Na - Gyeonggi-do, KR
Yu Chen - Tampa FL, US
Arjan van der Vaart - Tampa FL, US

Assignee:

Industry-University Cooperation Foundation Hanyang University - Seoul

International Classification:

A61K 31/40
A61K 31/357
A61P 35/02

Abstract:

The present invention relates to a composition including an inhibitor against the function of an Mi-2/NuRD chromatin remodeling complex for inhibiting metastasis and preventing and treating cancer diseases, and more particularly, the composition may inhibit the MBD2-p66α (GATAD2A) interaction by means of the Mi-2/NuRD CRC function inhibitor, and thus is expected to be effectively used as a composition capable of inhibiting metastasis and preventing and treating cancer diseases.

US Patent:

20160370285, Dec 22, 2016

Filed:

Jun 20, 2016

Appl. No.:

15/187727

Inventors:

- Bethesda MD, US
- College Park MD, US
Yu Chen - Rockville MD, US
Thomas Joshua Pfefer - Chevy Chase MD, US

International Classification:

G01N 21/27
A61B 5/00
G01N 33/49
C08L 83/04
C08J 3/00

Abstract:

Novel biophotonic phantoms are provided herein that can accurately mimic the optical properties of living tissue. The disclosed biophotonic phantoms comprise hemoglobin (Hb) in a native conformation that is distributed in a solid polymer matrix. Methods of producing the disclosed biophotonic phantoms are also provided. The biophotonic phantoms can be used, for example, to calibrate or test an optical imaging system, such as a near infrared spectroscopy imaging system.