Yu C Wang

US Patent:

6636136, Oct 21, 2003

Filed:

Dec 14, 2000

Appl. No.:

09/737084

Inventors:

Michael J. Radziun - Waterford WI
Scott T. Mansell - Waterford WI
Andrew T. Bollinger - Atlanta GA
Gregory A. Lehmann - Florence SC
Timothy J. Havens - Florence SC
Yu Wang - Clifton Park NY

Assignee:

GE Medical Systems Global Technology Company, LLC - Waukesha WI

International Classification:

H01F 500

US Classification:

335299, 335216

Abstract:

A mechanical stabilizer-tuned damper is attachable to the first upper magnet assembly of a high field open magnet, which magnet includes a first upper magnet assembly, a lower second magnet assembly and at least one non-magnetizable support beam therebetween. The mechanical stabilizer-tuned damper reduces the dynamic response of the magnet. A connecting device is provided which consists of a threaded rod mounted to an attachment bracket through a linear bearing and vibration mount. A series of non-magnetic and extremely low conductivity plates of various weights are attachable to the rod to change the mass and the tuning frequency of the damper. The location and size of the mechanical stabilizer-tuned damper are determined to balance the frequency of the field oscillation and physical room. The direction of orientation depends upon the direction of motion to be dampened or controlled.

US Patent:

6982351, Jan 3, 2006

Filed:

Dec 6, 2002

Appl. No.:

10/313530

Inventors:

Benjamin Frydman - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US

Assignee:

CellGate, Inc. - Redwood City CA

International Classification:

C07C 211/17

US Classification:

564453, 564153, 564445, 564454, 564455, 564457, 564461

Abstract:

Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

US Patent:

7026347, Apr 11, 2006

Filed:

Jun 24, 2003

Appl. No.:

10/606016

Inventors:

Benjamin Frydman - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Hirak S. Basu - Madison WI, US
Aparajita Sarkar - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Andrei V. Blokhin - Fitchburg WI, US

Assignee:

CellGate, Inc. - Redwood City CA

International Classification:

A61K 31/40
A61K 31/555
A61B 5/055
A61B 10/00
C07B 47/00

US Classification:

514410, 514185, 424 9362, 424 961, 540145, 534 15

Abstract:

Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.

US Patent:

7235695, Jun 26, 2007

Filed:

Aug 16, 2005

Appl. No.:

11/205341

Inventors:

Benjamin Frydman - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US

International Classification:

C07C 209/24
C07C 209/28
C07C 211/17

US Classification:

564468, 564153, 564445, 564453, 564454, 564455, 564457, 564461

Abstract:

Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

US Patent:

7453011, Nov 18, 2008

Filed:

Jun 4, 2007

Appl. No.:

11/810409

Inventors:

Linda Clifford, legal representative - Madison WI, US
Andrei V. Blokhin - Fitchburg WI, US
Aparajita Sarkar - Madison WI, US
Hirak S. Basu - Madison WI, US
Venodhar K. Reddy - Madison WI, US
Laurence J. Marton - Palo Alto CA, US
Yu Wang - Madison WI, US

Assignee:

Progen Pharmaceuticals, Inc. - Redwood City CA

International Classification:

C07C 211/13
A61K 31/13

US Classification:

564461, 564452, 564455, 564457, 514674

Abstract:

Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

US Patent:

8574837, Nov 5, 2013

Filed:

Dec 29, 2009

Appl. No.:

13/142438

Inventors:

Yu Wang - Madison WI, US
Andrew P. McMahon - Lexington MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 61, 435325, 435375, 536 234

Abstract:

The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also selectively labeling the membrane portion of the protein with another visual marker, such that upon exposure of the cell to a stimulus, the translocation of the cell membrane-associated protein may be observed directly.

US Patent:

20030072715, Apr 17, 2003

Filed:

Aug 2, 2001

Appl. No.:

09/922407

Inventors:

Benjamin Frydman - Madison WI, US
Manfred Hesse - Binz, CH
Armin Guggisberg - Schlieren, CH
Kasim Popaj - Schlieren, CH
Konstantin Drandarov - Zurich, CH
Hirak Basu - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US

International Classification:

A61K049/00
C07D245/00
C07F005/00

US Classification:

424/009363, 540/460000, 534/015000

Abstract:

Novel cyclic polyamine compounds of the form where A, each A(if present), and Aare independently selected from C-Calkyl, where each Y is independently selected from H or C-Calkyl, where M is selected from C-Calkyl, where k is 0, 2, or 3, and where R is selected from C-Calkyl, as well as all stereoisomers and salts thereof, are disclosed. Additional compounds where k is 1 and Ais independently selected from C-Calkyl or C-Calkyl are also disclosed. Cyclic polyamines, where the amide group is reduced to a secondary amino group, and various derivatives of these compounds, are also described. Synthetic methods for the compounds are described. The compounds are useful for treating diseases caused by uncontrolled proliferation of cells, such as cancer, especially prostate cancer, and for inducing intracellular ATP hydrolysis for treatment of other disorders.

US Patent:

20050130949, Jun 16, 2005

Filed:

Jan 27, 2005

Appl. No.:

11/046344

Inventors:

Benjamin Frydman - Madison WI, US
Manfred Hesse - Binz, CH
Armin Guggisberg - Schlieren, CH
Kasim Popaj - Schlieren, CH
Konstantin Drandarov - Zurich, CH
Hirak Basu - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US

International Classification:

C07D245/02
A61K031/506

US Classification:

514183000, 540460000

Abstract:

Novel cyclic polyamine compounds of the form