Yu J Zhang

US Patent:

8536316, Sep 17, 2013

Filed:

Aug 5, 2010

Appl. No.:

12/851082

Inventors:

Neil Soice - Amherst NH, US
John Dana Hubbard - Billerica MA, US
Yu Zhang - Chelmsford MA, US
James Hamzik - Waltham MA, US

Assignee:

EMD Millipore Corporation - Billerica MA

International Classification:

A23J 1/00
C07K 1/00

US Classification:

530413, 530416

Abstract:

The present invention relates, at least in part, to improved methods of protein purification. In particular, the present invention relates, at least in part, to methods for purifying an Fc region containing protein from a composition comprising the Fc region containing protein and one or more impurities, where the methods eliminate the need for a holding tank and/or a buffer exchange step.

US Patent:

20110313066, Dec 22, 2011

Filed:

May 16, 2011

Appl. No.:

13/108576

Inventors:

Jad Jaber - Sudbury MA, US
Wilson Moya - Concord MA, US
James Hamzik - Chelmsford MA, US
Arezki Boudif - Wakefield MA, US
Yu Zhang - Chelmsford MA, US
Neil Soice - Amherst NH, US
John Charkoudian - Carlisie MA, US
Nripen Singh - Burlington MA, US

Assignee:

Millipore Corporation - Billenca MA

International Classification:

B01J 39/20
C07K 1/36
C07K 1/30

US Classification:

521 31, 5303871, 5303881, 521 38

Abstract:

The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.

US Patent:

20130225701, Aug 29, 2013

Filed:

Jul 29, 2010

Appl. No.:

13/812965

Inventors:

Neil Soice - Groton MA, US
Joaquin Umana - Reading MA, US
Yu Zhang - Chelmsford MA, US

Assignee:

EMD MILLIPORE CORPORATION - Billerica MA

International Classification:

B01J 39/00

US Classification:

521 31

Abstract:

The invention relates to improved methods of grafting polymer extenders onto porous substrates having diffusive pores, such as those used in protein separations, without filing the diffusive pores of the substrate, and restricting diffusion there through. By changing the grafting conditions and/or monomer composition(s) the resulting porous substrates having polymer extenders grafted thereto have increased protein binding capacity and resin selectivity, thereby enhancing the protein separation effectiveness of the substrate. The grafted polymer extenders provide the substrate with significant binding capacity at higher conductivity. The invention also relates to kits, and methods of using and grafting polymer extenders on porous resin substrates having diffusive pores.

US Patent:

54591287, Oct 17, 1995

Filed:

Oct 27, 1994

Appl. No.:

8/330218

Inventors:

Barrett Rollins - Brookline MA
Yu J. Zhang - Brookline MA

Assignee:

Dana-Farber Cancer Institute - Boston MA

International Classification:

C07K 1452
C08H 100
A61K 3819
A61K 4505

US Classification:

514 8

Abstract:

The invention relates to a human MCP-1 derivative, and pharmaceutical compositions thereof, wherein human MCP-1 has been modified such that the protein inhibits monocyte chemoattractant activity. Successful inhibition of the activity is found where the MCP-1 is modified in one or more of the following: a) the 28-tyrosine is substituted by aspartate, b) the 24-arginine is substituted by phenylalanine, c) the 3-aspartate is substituted by alanine, and/or d) the 2-8 amino acid sequence is deleted. The claimed MCP-1 derivatives can be administered to a patient in need of inhibiting MCP-1 monocyte chemoattractant activity. For example, the derivatives can be used to prevent restenosis, such as that which is common in a patient undergoing coronary artery angioplasty. The invention further relates to compositions and methods of inhibiting monocyte chemoattractant activity of MCP-1 employing the derivatives described.

US Patent:

20200261157, Aug 20, 2020

Filed:

Feb 14, 2020

Appl. No.:

16/790989

Inventors:

- Santa Clara CA, US
Yu Zhang - Concord MA, US
Jeffrey A. Kasten - San Mateo CA, US

Assignee:

EchoPixel, Inc. - Santa Clara CA

International Classification:

A61B 34/10
A61F 2/24

Abstract:

A computer that determines at least an anatomic feature associated with an aortic valve is described. During operation, the computer generates a 3D image associated with an individual's heart. This 3D image may present a view along a perpendicular direction to a 2D plane in which bases of a noncoronary cusp, a right coronary cusp and a left coronary cusp reside. Then, the computer may receive information specifying a set of reference locations that are associated with an aortic-root structure. Next, the computer automatically determines, based, at least in part, on the set of reference locations, at least the anatomical feature, which is associated with an aortic valve of the individual and a size of an aortic-valve device used in a transcatheter aortic-valve replacement (TAVR) procedure.

US Patent:

20200265618, Aug 20, 2020

Filed:

Feb 14, 2020

Appl. No.:

16/790955

Inventors:

- Santa Clara CA, US
Yu Zhang - Concord MA, US
Jeffrey A. Kasten - San Mateo CA, US

Assignee:

EchoPixel, Inc. - Santa Clara CA

International Classification:

G06T 11/00
A61B 34/10
G16H 30/40
G16H 50/50

Abstract:

A computer that determines at least an anatomic feature of a left atrial appendage (LAA) is described. During operation, the computer generates a 3D image associated with an individual's heart. This 3D image may present a view along a perpendicular direction to an opening of the LAA. Then, the computer may receive information specifying a set of reference locations. For example, the set of reference locations may include: a location on a circumflex artery, a location between a superior portion of the LAA and a left pulmonary vein, and/or a location on a superior wall of the LAA and distal to trabeculae carneae. Next, the computer automatically determines, based, at least in part, on the set of reference locations, at least the anatomical feature of the LAA, which is associated with the opening of the LAA and a size of a device used in an LAA closure (LAAC) procedure.

US Patent:

20200066641, Feb 27, 2020

Filed:

Jul 2, 2016

Appl. No.:

16/305012

Inventors:

- Santa Clara CA, US
Richard J. DISCHLER - Bolton MA, US
Jeff C. MORRISS - Cornelius OR, US
Zhiguo QIAN - Chandler AZ, US
Wilfred GOMES - Portland OR, US
Yu Amos ZHANG - Chandler AZ, US
Ram S. VISWANATH - Phoenix AZ, US
Rajasekaran SWAMINATHAN - Tempe AZ, US
Sriram SRINIVASAN - Chandler AZ, US
Yidnekachew S. MEKONNEN - Chandler AZ, US
Sanka GANESAN - Chandler AZ, US
Eduard ROYTMAN - Newton Centre MA, US
Mathew J. MANUSHAROW - Phoenix AZ, US

International Classification:

H01L 23/538
H01L 25/065
H01L 23/522
H01L 23/528
H01L 23/00
H01L 23/60

Abstract:

Integrated circuit (IC) chip die to die channel interconnect configurations (systems and methods for their manufacture) may improve signaling to and through a single ended bus data signal communication channel by including on-die induction structures; on-die interconnect features; on-package first level die bump designs and ground webbing structures; on-package high speed horizontal data signal transmission lines; on-package vertical data signal transmission interconnects; and/or on-package electro-optical (EO) connectors in various die to die interconnect configurations for improved signal connections and transmission through a data signal channel extending through one or more semiconductor device package devices, that may include an electro-optical (EO) connector upon which at least one package device may be mounted, and/or be semiconductor device packages in a package-on-package configuration.

US Patent:

20200024560, Jan 23, 2020

Filed:

Aug 31, 2018

Appl. No.:

16/119022

Inventors:

Yu Shrike Zhang - Cambridge MA, US
Ali Khademhosseini - Los Angeles CA, US

Assignee:

United States of America, as Represented by the Secretary of the Navy - Arlington VA

International Classification:

C12M 3/00
G01N 33/50
C12N 5/074
C12N 5/077
C12N 5/071
C12M 3/06

Abstract:

A bioreactor and methods for use can include a microfibrous scaffold, that can be made of a composite bioink, and that can have endothelial cells directly embedded within the scaffold using an additive manufacturing process. The scaffold can further be seeded with cardiomyocytes. The hydrogel scaffold can be composed of a plurality of serpentine layers, with each serpentine layers, which can be placed on each other in a cross-hatch configuration, so that the primary axes of successive layers are perpendicular. This configuration can establish an aspect ratio for the scaffold, which can be selectively varied. For greater strength, the successive layers that have a primary axis in the same direction can be placed in the scaffold so that they are slight offset from each other. The scaffold can be placed in the bioreactor with perfusion, for use in cardiovascular drug screening and other nanomedicine endeavors.