Yufeng J Tseng

US Patent:

20170037448, Feb 9, 2017

Filed:

Apr 30, 2015

Appl. No.:

15/125716

Inventors:

Yufeng Jane TSENG - Stafford VA, US
- Taipei, TW
- Hsinchu, TW
- Miaoli County, TW
Chih-Min LIU - Taipei, TW
Wen-Sung LAI - Taipei, TW

International Classification:

C12Q 1/26
A61K 31/551
A61K 31/485
A61K 31/341
A61K 31/4706
A61K 31/4439
A61K 31/451

Abstract:

The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.