Yuhong Chang Zhang

US Patent:

20030224428, Dec 4, 2003

Filed:

Apr 11, 2003

Appl. No.:

10/413538

Inventors:

David Ron - New York NY, US
Marcella Calfon - New York NY, US
Heather Harding - Brooklyn NY, US
Yuhong Zhang - Elmhurst NY, US

International Classification:

A61K031/00
C12Q001/68
G01N033/567

US Classification:

435/006000, 435/007210, 514/001000

Abstract:

The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.

US Patent:

20100105064, Apr 29, 2010

Filed:

Dec 30, 2009

Appl. No.:

12/649849

Inventors:

David Ron - New York NY, US
Marcella Calfon - New York NY, US
Heather Harding - Brooklyn NY, US
Yuhong Zhang - Elmhurst NY, US

Assignee:

NEW YORK UNIVERSITY - New York NY

International Classification:

C12Q 1/68
C07H 21/02

US Classification:

435 6, 536 231

Abstract:

The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described.