Reference: APOE3ch alters microglial response and suppresses A-induced tau seeding and spread by Yun Chen, Sihui Song, Samira Parhizkar, Jennifer Lord, Yiyang Zhu, Michael R. Strickland, Chanung Wang, Jiyu Park, G. Travis Tabor, Hong Jiang, Kevin Li, Albert A. Davis, Carla M. Yuede, Marco Colonna
Date: Dec 25, 2023
Category: Health
Source: Google
Clues to preventing Alzheimer's come from patient who evaded disease, despite genetics
To solve this puzzle, Holtzman and first author Yun Chen, a graduate student, turned to genetically modified mice. They took mice genetically predisposed to overproduce amyloid and modified them to carry the human APOE gene with the Christchurch mutation. Then, they injected a tiny bit of human tau