Zhihua Li from San Jose, CA, age 49

Us Patents

Heparin-Associated Polypeptides And Uses Thereof
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US Patent:

20220409696, Dec 29, 2022
Filed:

Jun 10, 2022
Appl. No.:

17/837920
Inventors:

- Redwood City CA, US
Jeremy O'Connell - Palo Alto CA, US
Thach Mai - South San Francisco CA, US
Zhihua Li - San Jose CA, US
Assignee:

Juvena Therapeutics, Inc. - Redwood City CA
International Classification:

A61K 38/17
A61K 38/18
A61K 38/30
A61K 38/39
C07K 14/765
A61K 9/00
A61P 21/00
Abstract:

Described herein are polypeptides comprising an IGF2 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Mutations within the IGF2 amino acid sequence improved the stability of the molecule by reducing backbone cleavage. Also described herein are synergistic combinations of an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.

Resumes

Thermal Engineer

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Location:

San Jose, CA

Industry:

Semiconductors

Work:

Apple
Thermal Engineer
Amazon Lab126 Oct 2014 - Nov 2017
Manager, System Thermal Design
Intel Corporation Nov 2012 - Oct 2014
Staff Thermal Engineer
Intel Corporation 2005 - Nov 2012
Staff Engineer and Thermal Engineer
University of Minnesota Jan 2001 - Sep 2005
Research Assistant

Education:

University of Minnesota 2002 - 2005
Doctorates, Doctor of Philosophy, Philosophy University of Minnesota 2001 - 2002
Masters Tsinghua University 1995 - 2000
Bachelors, Computer Science, Engineering

Skills:

Thermal
Simulations
Heat Transfer
Design of Experiments
Semiconductors
Cfd
Testing
Mechanical Engineering
Ansys
Manufacturing
Materials Science
Characterization
Engineering Management
Research and Development
Electronics
Computational Fluid Dynamics
Thermal Analysis
Icepak
Packaging Thermal
Solidworks
Assembly Lines
Fmea
Abaqus
Design For Manufacturing
R&D
Flowtherm
Labview
Experimentation
Failure Mode and Effects Analysis
Fluent
Assembly Process
Flow3D
Hardware
Power
Research and Development

Languages:

Mandarin
English