Zhong Shan Li

US Patent:

6395726, May 28, 2002

Filed:

Jan 24, 2000

Appl. No.:

09/489623

Inventors:

Panayota Bitha - Nanuet NY
Zhong Li - Congers NY
Gerardo D. Francisco - Orangeburg NY

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

A01N 4300

US Classification:

51421005, 540310

Abstract:

Compounds are provided having the following formulae I and II: wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group; X is CH or NH; R is cyano, methoxy, or acetamido; R is hydrogen, alkyl, a negative charge, a cation selected from the group consisting of sodium, potassium and tetraalkylammonium and acyloxyalkyl, or alkoxycarbonyloxyalkyl; and R is hydrogen, acyl, trisubstituted silyl carbamoyl or an amino acid residue; or pharmaceutically acceptable salts thereof.

US Patent:

6649756, Nov 18, 2003

Filed:

Jul 9, 2001

Appl. No.:

09/901335

Inventors:

Tarek Mansour - New City NY
Zhong Li - Congers NY

Assignee:

Wyeth, Five Giralda Farms - Madison NJ

International Classification:

C07D47720

US Classification:

540350

Abstract:

The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylic acid by hydrogenation of 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[2R,3R)-2-({[(2S)-3-methyl-2-({[4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}methyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylate in a biphasic solvent mixture comprising a water portion and an organic solvent portion, not containing an acid acceptor. The water portion is separated from the organic solvent portion and (4R,5S,6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[R-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylic acid is isolated from the separated water portion by lyophilization or reverse osmosis.

US Patent:

6727232, Apr 27, 2004

Filed:

Apr 25, 2002

Appl. No.:

10/131939

Inventors:

Zhong Li - Congers NY
Gerardo DelaCruz Francisco - Orangeburg NY
Leonard Alexander McDonald - Mountainside NJ

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A01N 4304

US Classification:

514 50, 514 43, 514 49, 536 221, 536 281, 536 284, 536 2853, 536 553

Abstract:

This invention relates to antibiotic compounds AA896 of the formula wherein: R is H, aryl, alkyl (C -C ), âCH -aryl, âC(O)alkyl(C -C ), âC(O)NHalkyl(C -C ), or âC(O)NHaryl; R is H, alkyl (C -C ), âCH aryl, alkyl (C -C ) or âC(O)alkyl(C -C ); R is âOH; R and R may optionally be taken together to form a moiety R is alkyl (C -C ), or aryl; or a pharmaceutically acceptable salt thereof.

US Patent:

7595327, Sep 29, 2009

Filed:

Mar 16, 2006

Appl. No.:

11/377886

Inventors:

Jeremy I. Levin - New City NY, US
Zhong Li - Congers NY, US
George Diamantidis - Randolph NJ, US
Frank E. Lovering - Acton MA, US
Weiheng Wang - Bedford MA, US
Jeffrey S. Condon - Cambridge MA, US
Jerauld S. Skotnicki - Westfield NJ, US
Kaapjoo Park - Congers NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/44
C07D 453/02

US Classification:

514306, 514451, 514461, 546134, 546135, 549356, 549362, 549429

Abstract:

This invention provides compounds of Formula I, having the structure:.

US Patent:

20040219567, Nov 4, 2004

Filed:

Nov 5, 2003

Appl. No.:

10/703063

Inventors:

Andrea Califano - New York NY, US
Aristidis Floratos - Astoria NY, US
Zhong Li - Rutherford NJ, US
David Wang - Kildeere IL, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

A pattern discovery-based method for identifying genetic associations in mapping complex traits. In one embodiment, this invention describes the applicable study designs, the pattern discovery algorithm on phenotypic/genotypic data, and methods to evaluate statistical significance of identified patterns. Patterns identified through the proposed methods act as signatures or profiles that can be used to locate genes or genomic regions responsible for the traits of interests in the genome. This invention has been successfully applied to two independent datasets collected from actual genetic studies and has produced significant results.

US Patent:

20070219183, Sep 20, 2007

Filed:

Mar 15, 2007

Appl. No.:

11/724489

Inventors:

Jeremy Ian Levin - New City NY, US
Zhong Li - Congers NY, US
Dennis Powell - Cortlandt Manor NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/554
A61K 31/553
A61K 31/551
A61K 31/541
A61K 31/5377
A61K 31/519
C07D 487/04

US Classification:

51421115, 5142591, 5142593, 5142342, 51425216, 5142278, 514218, 51421706, 544281, 544114, 544 60, 540575, 540544, 540600

Abstract:

The present invention relates to dihydropyrazolo[1,5-a]pyrimidine and dihydroimidazo[1,5-a]pyrimidine derivatives, compositions comprising an effective amount of a dihydropyrazolo[1,5-a]pyrimidine or a dihydroimidazo[1,5-a]pyrimidine derivative and methods for treating or preventing cancer, comprising administering to a subject in need thereof an effective amount of a dihydropyrazolo[1,5-a]pyrimidine or a dihydroimidazo[1,5-a]pyrimidine derivative.

US Patent:

20090254588, Oct 8, 2009

Filed:

Jun 19, 2007

Appl. No.:

11/764958

Inventors:

Zhong Li - Livingston NJ, US

International Classification:

G06F 17/30

US Classification:

707201, 707E17007

Abstract:

The invention is directed to a system and method for merging at least two datasets each having at least two keys and each having a plurality of data elements. The system determines a quantity of shared data elements in each dataset for each key as well as a quantity of unique data elements in each dataset for each key. The system then generates a graphical output representing the quantity of shared and unique data elements in each dataset for each key. The system receives a selection input selecting one of a plurality of merge strategies. Each merge strategy is based on the quantity shared or unique data elements in each dataset for each key. The system then generates a merged dataset containing data elements from the at least two datasets based on the at least two keys and the selected merge strategy.

US Patent:

20110028455, Feb 3, 2011

Filed:

Dec 12, 2008

Appl. No.:

12/746855

Inventors:

Diane Harris Boschelli - New City NY, US
Yanong Daniel Wang - Warren NJ, US
Amarnauth Shastrie Prashad - New City NY, US
Zhong Li - Congers NY, US
Chuansheng Niu - Cheshire CT, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 31/551
C07D 401/12
A61K 31/4439
A61P 11/06
A61P 19/02
A61P 17/06
A61P 1/00
C07D 405/14
A61K 31/496
C07D 401/14
A61K 31/4545
C07D 413/14
A61K 31/5355

US Classification:

514218, 5462774, 514339, 544364, 51425309, 544373, 51425409, 546194, 514318, 544129, 5142352, 540575

Abstract:

Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X is —O—, —N(R)—, —S—, —S(O)— or —S(O)—; Ris a Calkyl group or —CF; and R, R, Rand p are as defined herein; wherein the compounds are useful as kinase inhibitors. Also disclosed are pharmaceutical compositions containing, and intermediate compounds and methods for making the compounds of formula (I) and their pharmaceutically acceptable salts; and methods of using the foregoing to treat inflammatory and autoimmune diseases such as asthma, colitis, multiple sclerosis, psoriasis, arthritis, rheumatoid arthritis, inflammatory bowel disease, and joint inflammation.