Allyn Edward Hubbard

US Patent:

6338820, Jan 15, 2002

Filed:

Aug 14, 1998

Appl. No.:

09/134141

Inventors:

Allyn Hubbard - Medfield MA
Samesh Kale - Allston MA
Scott A. Rollins - Oxford CT
Jeremy P. Springhorn - Guilford CT
Stephen P. Squinto - Bethany CT

Assignee:

Alexion Pharmaceuticals, Inc. - Cheshire CT

International Classification:

G01N 3500

US Classification:

422 64, 422 63, 422 65, 422 67, 422 72, 422100, 436 43, 436 45, 436 50, 436164, 436165, 436180

Abstract:

An apparatus for performing a assays includes an axially rotatable substrate including a plurality of layers of a semiconductor material and numerous radially-arrayed reaction sites. The apparatus further includes a rotary stepper motor which rotates the substrate at an adjustable and substantially continuous speed and controls the rotation of the substrate by adjusting the speed and a direction of rotation. In addition, the apparatus includes a dual function head which has a fluid dispenser that has a fluid dispenser outlet and delivers a fluid to a reaction site and also has a readout device that has a sensor which receives an identifying signal from the reaction site on the substrate or scans the substrate to read identifying marks at the reaction site. Moreover, the apparatus may be aligned by a computer having a memory for storing a start location for the dispenser outlet on the substrate and additional electronics. The computer provides movement signals to the rotary stepper motor and a linear stepper motor on which the dispenser outlet is mounted, whereby the motors align the dual function head over the substrate, such that the dispenser outlet is aligned over the reaction site.

US Patent:

6905657, Jun 14, 2005

Filed:

Apr 5, 2001

Appl. No.:

09/827570

Inventors:

Allyn Hubbard - Medfield MA, US
Samesh Kale - Alliston MA, US
Scott Rollins - Oxford CT, US
Jeremy P. Springhorn - Guilford CT, US
Stephen P. Squinto - Bethany CT, US
Prasad R. Akkapeddi - Fairfax VA, US

Assignee:

BioProcessors Corp. - Woburn MA

International Classification:

B01L003/02
G01N001/10
B65B001/04

US Classification:

422100, 422920, 422924, 422 99, 436180, 141318, 7386332, 73864, 7386401, 7386411, 7386414, 7386434

Abstract:

In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween. The handling system enables a method for storing and dispensing liquids including drawing a liquid sample into the channels either by capillary action, vacuum, electrostatic flow, a minipump or any combination thereof, storing the liquid sample into the cartridge, and dispensing the liquid sample.

US Patent:

7098718, Aug 29, 2006

Filed:

Dec 10, 2004

Appl. No.:

11/009377

Inventors:

Zibing Yang - Natick MA, US
Todd A. Hinck - Arlington MA, US
Howard I. Cohen - Waltham MA, US
Allyn Hubbard - Medfield MA, US

Assignee:

The Trustees of Boston University - Boston MA

International Classification:

H06G 7/19

US Classification:

327336, 327552, 327553, 327558

Abstract:

A tunable current mode integrator for low-frequency continuous-time filters that requires a reduced amount of area when implemented in an integrated circuit (IC). The integrator includes input and output transistors, and cross-coupled current mirrors, integration capacitors, and operational transconductance amplifiers (OTAs) that form a feedback structure with the input transistors. Input currents are converted to small current swings within the OTAs, and are subsequently integrated by the capacitors. Resulting integrated voltages are converted to output currents by the output transistors.

US Patent:

7495998, Feb 24, 2009

Filed:

May 1, 2006

Appl. No.:

11/415347

Inventors:

Socrates Deligeorges - Roslindale MA, US
Allyn Hubbard - Medfield MA, US
David Mountain - Byfield MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

G01S 3/802

US Classification:

367127

Abstract:

An acoustic detection and localization system includes a signal acquisition stage, a biomimetic processor, and an acoustic feature processor. The system uses multiple acoustic cues including spectral content, inter-aural time delay (ITD), inter-aural intensity difference (IID), and periodicity content to detect, classify, and localize sound sources. Pairs of acoustic sensors are arranged geometrically with a spacing depending on the application. The biomimetic processing provides for echo suppression to enhance performance in reverberant environments, and automatic gain controls for robustness in noisy environments. Applications include mobile robotic platforms for reconnaissance and surveillance, helmet mounted systems for sniper detection, vehicle-mounted systems for combat awareness, general civilian security systems, and systems for environmental monitoring and tracking of animals.

US Patent:

20050118074, Jun 2, 2005

Filed:

Dec 28, 2004

Appl. No.:

11/024158

Inventors:

Allyn Hubbard - Medfield MA, US
Samesh Kale - Burlington MA, US
Scott Rollins - Oxford MA, US
Jeremy Springhorn - Guilford CT, US
Stephen Squinto - Bethany CT, US
Prasad Akkapeddi - Fairfax VA, US

Assignee:

BioProcessors Corp. - Woburn MA

International Classification:

B01L003/02

US Classification:

422100000

Abstract:

In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween. The handling system enables a method for storing and dispensing liquids including drawing a liquid sample into the channels either by capillary action, vacuum, electoosmotic flow, a minipump or any combination thereof, storing the liquid sample into the cartridge, and dispensing the liquid sample.

US Patent:

52276597, Jul 13, 1993

Filed:

Dec 27, 1991

Appl. No.:

7/815834

Inventors:

Allyn E. Hubbard - Milton MA

Assignee:

Trustees of Boston University - Boston MA

International Classification:

H01L 2702

US Classification:

257531

Abstract:

An integrated circuit inductor is disclosed which can be fabricated by adding simple follow-on steps to standard fabrication line processes. In a preferred embodiment, standard CMOS technology is used to fabricate a multi-turn coil having its axis normal to the layers of oxide, polysilicon, and metal which form the coil. For a coil 100 microns on a side, an inductance on the order of 10 nH can be achieved. By including a magnetic core in the design using the disclosed procedure, this value can be increased to as high as 0. 1 mH. Thus, inductor values ranging from 0. 001 mH-0. 1 mH can be physically implemented as integrated, highly-miniaturized CMOS designs for analog operation in the range of approximately 1-100 MHz.

US Patent:

53885775, Feb 14, 1995

Filed:

May 4, 1993

Appl. No.:

8/057692

Inventors:

Allyn E. Hubbard - Milton MA

Assignee:

Boston University - Boston MA

International Classification:

H01L 2348
A61B 504

US Classification:

128639

Abstract:

An electrode array microchip, fabricated preferrably using CMOS technology, comprising electrodes made with overglass cuts over metal2 regions is disclosed. Overglass cuts of dimensions approximately an order of magnitude smaller than dimensions quoted in current design rules for CMOS technology are successfully employed to make exposed electrodes of dimensions on the order of microns. Thus, the electrode array chip can be produced cheaply on commercial fabrication lines. The invention finds many uses in biology and medicine, particularly when applied to the measurement of neural electrical activity.