Christopher A Murphy

US Patent:

20130184318, Jul 18, 2013

Filed:

Apr 28, 2011

Appl. No.:

13/643543

Inventors:

Paul Russell - Davis CA, US
Christopher J. Murphy - Davis CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12Q 1/02

US Classification:

514369, 435 29, 548187, 435375, 435 612, 435 71

Abstract:

The present invention provides methods of determining the effect of test agents on the compliance of trabecular meshwork (TM) tissue, at the level of the extracellular matrix (ECM) and/or cells within the TM. Agents that modulate (e.g., increase or decrease) compliance of the TM tissue find use. Agents that increase the compliance of ECM and TM cells within the TM find use in the treatment and prevention of eye disorders characterized by high intraocular pressure, e.g., glaucoma.

US Patent:

20130211542, Aug 15, 2013

Filed:

Feb 7, 2013

Appl. No.:

13/762290

Inventors:

The Regents of the University of California - , US
Christopher J. Murphy - Davis CA, US
Paul Russell - Davis CA, US
Shaun P. Garland - Davis CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61F 2/02
B29C 59/02
B29C 35/08
B05D 3/10

US Classification:

623 2372, 427 21, 216 37, 264220, 264494

Abstract:

The present invention provide methods for preparing nanostructured membranes. The methods include: providing a substrate with a charged silanized surface; forming a multilayered membrane containing at least two polyelectrolytes; inducing polyelectrolyte phase separation; crosslinking the multilayered membrane; and covalently linking the multilayered membrane to the silanized surface. Methods for fabricating membrane replicas are also disclosed, as well as devices such as cell- and tissue-culture substrates that contain the membranes and membrane replicas. Resulting materials exhibit topographic features and compliance of the extracellular matrix in vivo.

US Patent:

52429024, Sep 7, 1993

Filed:

Sep 6, 1989

Appl. No.:

7/404249

Inventors:

Christopher J. Murphy - Davis CA
Ted W. Reid - Davis CA
Mark J. Mannis - Carmichael CA
Bradley A. Foster - Davis CA
James S. Cullor - Woodland CA
Michael E. Selsted - Los Angeles CA
Robert I. Lehrer - Santa Monica CA
Tomas Ganz - Los Angeles CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3702
A61K 3700
C07K 710

US Classification:

514 12

Abstract:

A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having both a mitogenic activity capable of stimulating cell growth and an antimicrobial activity capable of inhibiting the growth of a wide variety of pathogens. In addition to therapeutic use, the defensins are useful as mitogens in cell and tissue culture media.

US Patent:

20230069586, Mar 2, 2023

Filed:

Jan 8, 2021

Appl. No.:

17/790594

Inventors:

- Oakland CA, US
Christopher J. Murphy - Davis CA, US

International Classification:

A61K 31/365
A61K 31/12
A61K 45/06

Abstract:

Provided herein are methods of using andrographolide, oridonin, isoliquiritigenin, and derivatives thereof to upregulate β-defensin 3 expression in humans and other veterinary animals. Upregulated β-defensin 3 expression is useful in a number of contexts including the prevention of infections, promotion of mucosal health, treatment of wounds, and the treatment of respiratory conditions.

US Patent:

20160215285, Jul 28, 2016

Filed:

Dec 4, 2015

Appl. No.:

14/960310

Inventors:

- Oakland CA, US
Christopher J. MURPHY - Davis CA, US
Sara M. THOMASY - Sacramento CA, US
Vijay Krishna RAGHUNATHAN - Davis CA, US
Joshua T. MORGAN - Davis CA, US
Joshua WOOD - Vacaville CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 15/113
A61K 31/7088
A61K 45/06
A61K 9/00

Abstract:

The present invention relates to method, system, and composition for modulating the compliance of the trabecular meshwork, which may provide treatment to glaucoma.

US Patent:

20140234419, Aug 21, 2014

Filed:

Apr 28, 2014

Appl. No.:

14/263087

Inventors:

- Oregon WI, US
Christopher Murphy - Davis CA, US
Nicholas Abbott - Madison WI, US

Assignee:

WOUND ENGINEERING LLC - Oregon WI

International Classification:

A61K 9/70

US Classification:

424484

Abstract:

The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polymers to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.

US Patent:

20140187607, Jul 3, 2014

Filed:

Dec 19, 2013

Appl. No.:

14/134991

Inventors:

- Oakland CA, US
Christopher J. MURPHY - Davis CA, US
Sara M. THOMASY - Sacramento CA, US
Vijay Krishna RAGHUNATHAN - Davis CA, US
Joshua T. MORGAN - Davis CA, US
Joshua WOOD - Vacaville CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12N 15/113
C07D 493/06

US Classification:

514 44 A, 514369

Abstract:

The present invention relates to method, system, and composition for modulating the compliance of the trabecular meshwork, which may provide treatment to glaucoma.