Francisco Alvarez

US Patent:

55232892, Jun 4, 1996

Filed:

Jun 17, 1993

Appl. No.:

8/078807

Inventors:

Francisco J. Alvarez - Lindenhurst IL
Kathy M. O'Connor - Round Lake Beach IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31195
A61K 3119
A61K 3800

US Classification:

514 19

Abstract:

A pharmaceutical tablet composition comprising a compound of the formula (II): ##STR1## wherein R. sub. 1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R. sub. 2 is benzyl, p-methoxybenzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl; R. sub. 3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH. sub. 3 S-- or CH. sub. 3 SCH. sub. 2 --; R. sub. 4 is loweralkyl or cyclopropyl; R. sub. 5 is hydrogen or loweralkyl; and X is CH. sub. 2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof, and a pharmaceutically acceptable organic polycarboxylic acid. In addition, the tablet composition can further comprise one or more pharmaceutically acceptable non-ionic surfactants.

US Patent:

55914519, Jan 7, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/484693

Inventors:

Pramod K. Gupta - Gurnee IL
Francisco J. Alvarez - Lindenhurst IL
Susan J. Semla - Evanston IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 920

US Classification:

424464

Abstract:

A pharmaceutical tablet containing a therapeutically active compound and between 5% and about 20% by weight of an oil, preferably selected from vegetable, mineral, animal and edible oils, as well as a method for preparing such tablets. Such tablets provide for the controlled release of the therapeutically active compound from the tablet and also enhance the stability of some therapeutically active compounds.

US Patent:

53345894, Aug 2, 1994

Filed:

Jun 25, 1992

Appl. No.:

7/867200

Inventors:

Francisco J. Alvarez - Lindenhurst IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3147
C07D21556

US Classification:

514185

Abstract:

Compositions of a quinolone carboxylic acids useful for oral or parenteral administration to a human or veterinary patient are disclosed which comprise quinolone carboxylic acid--metal ion--acid complexes in combination with a physiologically acceptable carrier and having a pH of about 4 to about 10, as well as a method for their production and use in treatment. Such compositions are found to cause unexpectedly low levels of vein irritation upon intravenous administration.