ET Healthcare - Palo Alto, Shanghai, Suzhou since Sep 2008
Co-founder and CEO
ForteBio Inc - Menlo Park, Shanghai Oct 2001 - Aug 2008
Founder and CTO
Wave Crossing Corporation - Fremont, Shanghai Mar 2000 - Oct 2001
Founder and CEO
Education:
Cheung Kong Graduate School of Business 2008 - 2010
Executive MBA, Business Administration
Auburn University
PhD, Electrical Engineering
Auburn University
MSEE, Electrical Engineering
Xi'an Jiaotong University
BSEE, Electrical Engineering
Stephen J. Williams - San Mateo CA Hong Dong Tan - San Jose CA Hung Pin Kao - Fremont CA Wyatt N. Vreeland - Chicago IL
Assignee:
Aclara Biosciences, Inc. - Mountain View CA
International Classification:
B01D 5902
US Classification:
204549
Abstract:
A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing-edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte. With the application of a voltage potential across the microchannel, charged components in the sample stack by isotachophoresis, and electrolytic hydroxyl or hydrogen ions formed by electrolysis at the upstream-end electrode migrate into the trailing-edge ion buffer, titrating the titratable species therein, where the concentration of the titratable species in the trailing-edge electrolyte is selected, in relation to the lengths of the upstream channel region and sample-loading volume, to permit the sample to stack into a relatively small sample volume before electrolytic-ion migration from the upstream electrode into and through the sample-volume region is effective to overtake the charged sample components. With continued application of an electric potential across the channel ends, charged sample components in the stacked sample volume separate by zone electrophoresis.
Microfluidic Device With Sample Injector And Method Of Using
Stephen J. Williams - San Mateo CA Hong Dong Tan - San Jose CA Hung Pin Kao - Fremont CA Wyatt N. Vreeland - Chicago IL
Assignee:
Aclara Biosciences, Inc. - Mountain View CA
International Classification:
B01D 5702
US Classification:
204453, 204601, 204450
Abstract:
A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having upstream and downstream channel portions and first, second, and third side channels that intersect the electrolyte channel between the two channel portions at first, second, and third ports, respectively. In the method, a sample is moved electrokinetically into the electrolyte channel, to form a defined sample volume therein. By simultaneously controlling the voltage applied to the three side channels, and at least one of the upstream and downstream channel end portions, the sample volume element can be shaped to have a desired leading- and trailing-edge shape and/or distribution of sample components within the volume elements.
Hong Tan - Fremont CA, US Youmin Liu - Palo Alto CA, US Yushan Tan - Shanghai, CN
Assignee:
Wave Crossing Corporation - Palo Alto CA
International Classification:
C03B 2500
US Classification:
65 3013, 65 3014, 65114
Abstract:
A fabrication method for a thallium-doped GRIN lens composed of a simplified glass composition is described. The composition is composed of silicon, oxygen, boron, zinc, potassium, sodium, and thallium. The method is comprised of preparing a cylindrical preform, annealing the cylindrical preform, removing contaminants from preform thereafter extruded to form a glass rod, exposing the glass rod to an alkali salt bath, and chemically milling the glass rod within an acid bath. Method and composition produce colorless lenses with a refractive index from 1. 5900 to 1. 7810, an insertion loss no greater than 0. 05 dB, and a chromatic transmittance greater than 90 percent.
Tandem Isotachophoresis/Zone Electrophoresis Method And System
Stephen J. Williams - San Mateo CA, US Hong Dong Tan - San Jose CA, US Hung Pin Kao - Fremont CA, US Wyatt N. Vreeland - Chicago IL, US
Assignee:
Monogram Biosciences, Inc. - South San Francisco CA
International Classification:
G01N 27/447
US Classification:
204645, 204549, 204601
Abstract:
A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing-edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte. With the application of a voltage potential across the microchannel, charged components in the sample stack by isotachophoresis, and electrolytic hydroxyl or hydrogen ions formed by electrolysis at the upstream-end electrode migrate into the trailing-edge ion buffer, titrating the titratable species therein, where the concentration of the titratable species in the trailing-edge electrolyte is selected , in relation to the lengths of the upstream channel region and sample-loading volume, to permit the sample to stack into a relatively small sample volume before electrolytic-ion migration from the upstream electrode into and through the sample-volume region is effective to overtake the charge sample components. With continued application of an electric potential across the channel ends, charged sample components in the stacked sample volume separated by zone electrophoresis.
Robert F. Zuk - Atherton CA, US Hong Tan - San Jose CA, US
Assignee:
Access Medical Systems, Ltd. - Palo Alto CA
International Classification:
G01N 33/543
US Classification:
436518, 422401, 422402, 422408
Abstract:
The present invention is directed immunoassay cuvettes that comprise diffusely bound and non-diffusely bound reagents for carrying out an immunoassay. The reaction and detection are carried out in the immunoassay cuvette. The immunoassay cuvette comprises a transparent front wall, a back wall, side walls, a bottom, and a top opening. The back wall of the cuvette has a substantially planar surface made of a non-porous material and comprises a capture zone having reagents non-diffusedly bound and a signal reagent zone having reagents diffusedly bound.
Michael W. Recknor - Oakland CA, US Hong Tan - San Jose CA, US Robert Zuk - Atherton CA, US Krista Leah Witte - Hayward CA, US Sae Choo - Sunnyvale CA, US Scott Lockard - Los Gatos CA, US
An apparatus and method for packaging of an optical sensing fiber is disclosed. The apparatus includes a substrate with a plurality of openings, and each opening is configured for holding an optical sensing assembly. The assembly is positioned in the opening with a tip of the assembly extending through the opening to be suspended from the substrate. In addition, openings are arranged so the assembly positioned therein avoids contacting another assembly positioned therein. The apparatus can include a support member for supporting the substrate and positioning the substrate so the tip of the assembly suspended from the opening in the substrate contacts solution in one of a plurality of wells in a container adjacent to the substrate. The assembly can be configured for preparing of the optical assembly for assay. An agitation assembly for agitating the container to create flow of the solution in the container wells over an optical sensing assembly is also disclosed.
Robert F. Zuk - Atherton CA, US Hong TAN - San Jose CA, US
International Classification:
A61B 5/151 A61B 17/34
US Classification:
600583, 606181, 606182
Abstract:
An improved lancet as well as methods and devices for using the improved lancet are provided. The improved lancet comprises a body section with a lance arm and one or more protective arms extending from the body section. The lance arm has a lance with a sharp portion for piercing skin disposed on the lance arm. The sharp portion of the lance extends at an angle of about 45 to 135 degrees to the direction of extension of the lance arm from the body section. The protective arms have a protective section for shielding the sharp portion of the lance. The sharp portion of the lance is exposed from the protective section by application of pressure to the lance arm.
Michael W. Recknor - Oakland CA, US Hong Tan - San Jose CA, US Robert Zuk - Atherton CA, US Krista Leah Witte - Hayward CA, US Sae Choo - Sunnyvale CA, US Scott Lockard - Los Gatos CA, US
Assignee:
ForteBio, Inc. - Menlo Park CA
International Classification:
G01N 21/75 G01N 21/84 G01N 30/00 G01B 9/02
US Classification:
436164, 356427, 422 69, 356450
Abstract:
An apparatus and method for packaging of an optical sensing fiber is disclosed. The apparatus includes a substrate with a plurality of openings, and each opening is configured for holding an optical sensing assembly. The assembly is positioned in the opening with a tip of the assembly extending through the opening to be suspended from the substrate. In addition, openings are arranged so the assembly positioned therein avoids contacting another assembly positioned therein. The apparatus can include a support member for supporting the substrate and positioning the substrate so the tip of the assembly suspended from the opening in the substrate contacts solution in one of a plurality of wells in a container adjacent to the substrate. The assembly can be configured for preparing of the optical assembly for assay. An agitation assembly for agitating the container to create flow of the solution in the container wells over an optical sensing assembly is also disclosed.