Hyun K Kim

US Patent:

6768014, Jul 27, 2004

Filed:

Jun 27, 2002

Appl. No.:

10/169139

Inventors:

Hyun Koo Kim - Bethesda MD
Pemmaraju N. Rao - San Antonio TX
James W. Cessac - San Antonio TX
Anne Marie Simmons - San Antonio TX

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07J 500

US Classification:

552595

Abstract:

A compound having general formula (I) in which R is a member selected from the group consisting of âOCH , âSCH , âN(CH ) , âNHCH , âCHO, âCOCH and âCHOHCH ; R is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of âO and âNâOR , wherein R is a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of formula (I), the present invention provides methods wherein the compounds of formula (I) are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception.

US Patent:

6861415, Mar 1, 2005

Filed:

Apr 30, 1997

Appl. No.:

09/180132

Inventors:

Hyun K. Kim - Bethesda MD, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - San Antonio TX, US
Carmie K. Acosta - San Antonio TX, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K031/56
C07J005/00
C07J009/00

US Classification:

514179, 514182, 514841, 552556, 552595, 552598, 552602, 552608

Abstract:

A compound having the general formula: in which: Ris a member selected from the group consisting of —OCH, —SCH, —N(CH), —NHCH, —CHO, —COCHand —CHOHCH; Ris a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; Ris a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; Ris a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR, wherein Ris a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception.

US Patent:

6900193, May 31, 2005

Filed:

Mar 17, 2000

Appl. No.:

09/526855

Inventors:

Hyun K. Kim - Bethesda MD, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - San Antonio TX, US
Carmie K. Acosta - San Antonio TX, US
Anne Marie Simmons - San Antonio TX, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K031/56
A61K031/58
C07J005/00
C07J009/00
C07J043/00

US Classification:

514179, 514176, 514177, 514182, 514841, 540107, 552556, 552595, 552598, 552602, 552608

Abstract:

The present invention relates, inter alia, to compounds having the general formula: in which: Ris a member selected from the group consisting of —OCH, —SCH, —N(CH), —NHCH, —NCH, —NCH, —NCHO, —CHO, —CH(OH)CH, —C(O)CH, —O(CH)N(CH), and —O(CH)NCH; Ris a member selected from the group consisting of hydrogen, halogen, alkyl, acyl, hydroxy, alkoxy (e. g. , methoxy, ethoxy, vinyloxy, ethynyloxy, cyclopropyloxy, etc. ), acyloxy (e. g. , acetoxy, glycinate, etc. ), alkylcarbonate, cypionyloxy, S-alkyl, —SCN, S-acyl and —OC(O)R, wherein Ris a functional group including, but not limited to, alkyl (e. g. , methyl, ethyl, etc. ), alkoxy ester (e. g. , —CHOCH) and alkoxy (—OCH); Ris a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; Ris a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR, wherein Ris a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception.

US Patent:

6944991, Sep 20, 2005

Filed:

Dec 29, 2003

Appl. No.:

10/745591

Inventors:

Hyun T. Kim - Springfield VA, US

International Classification:

E04D013/04
E04D013/064

US Classification:

52 11, 52 12, 52 14, 52 15, 248 481, 248 482

Abstract:

A rain gutter cover for covering the gutter, includes a large space screen a curved upper leg portion extended from a roof shingle for engaging with an upper end of the large space screen, and a plurality of supports attached to the curved front leg portion and to a lower leg portion whereby the rain gutter can keep out leaves and other debris, and allow water to enter thereinto and fall down into the gutter effectively and accurately.

US Patent:

7087591, Aug 8, 2006

Filed:

Feb 23, 2005

Appl. No.:

11/065632

Inventors:

Hyun K. Kim - Bethesda MD, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - San Antonio TX, US
Carmie K. Acosta - San Antonio TX, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 31/56
C07J 5/00

US Classification:

514179, 514182, 552595, 552598

Abstract:

A compound having the general formula:In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception.

US Patent:

7196074, Mar 27, 2007

Filed:

Oct 28, 2002

Appl. No.:

10/281794

Inventors:

Richard P. Blye - Highland MD, US
Hyun K. Kim - Bethesda MD, US
Pemmaraju Narasimha Rao - San Antonio TX, US
Carmie Kirk Acosta - San Antonio TX, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 31/56
C07J 41/00

US Classification:

514178, 514179, 514182, 514169, 514170, 552525, 552539, 552575, 552632, 552639, 552641, 552515

Abstract:

Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III).

US Patent:

7233706, Jun 19, 2007

Filed:

Jan 4, 2007

Appl. No.:

11/619926

Inventors:

Hyun Mun Kim - Rockville MD, US
Jong Beom Ra - Taejeon-si, KR
Sung Deuk Kim - Taejeon-si, KR
Young Su Lee - Seoul, KR

Assignee:

LG Electronics Inc. - Seoul

International Classification:

G06T 5/10

US Classification:

382268, 37524027

Abstract:

A method of coding a moving picture is provided that reduces blocking artifacts. The method can include defining a plurality of defining pixels S, S, and S, which are centered around a block boundary. If a default mode is selected then frequency information of the surroundings of the block boundary is obtained. A magnitude of a discontinuous component in a frequency domain belonging to the block boundary is adjusted based on a magnitude of a corresponding discontinuous component selected from a pixel contained entirely within a block adjacent the block boundary. The frequency domain adjustment is then applied to a spatial domain. Or, a DC offset mode can be selected to reduce blocking artifacts in smooth regions where there is little motion.

US Patent:

7239755, Jul 3, 2007

Filed:

Feb 18, 2000

Appl. No.:

09/506728

Inventors:

Hyun Mun Kim - Rockville MD, US
Jong Beom Ra - Taejeon-si, KR
Sung Deuk Kim - Taejeon-si, KR
Young Su Lee - Seoul, KR

Assignee:

LG Electronics Inc. - Seoul

International Classification:

G06T 5/10

US Classification:

382268, 37524027

Abstract:

A method of coding a moving picture is provided that reduces blocking artifacts. The method can include defining a plurality of defining pixels S, S, and S, which are centered around a block boundary. If a default mode is selected then frequency information of the surroundings of the block boundary is obtained. A magnitude of a discontinuous component in a frequency domain belonging to the block boundary is adjusted based on a magnitude of a corresponding discontinuous component selected from a pixel contained entirely within a block adjacent the block boundary. The frequency domain adjustment is then applied to a spatial domain. Or, a DC offset mode can be selected to reduce blocking artifacts in smooth regions where there is little motion.