Janet D Newman

US Patent:

6656267, Dec 2, 2003

Filed:

Jul 10, 2001

Appl. No.:

09/903341

Inventors:

Janet Newman - Encinitas CA

Assignee:

Structural Genomix, Inc. - San Diego CA

International Classification:

C30B 900

US Classification:

117 11, 117 1, 117 5, 117206, 117925, 117927, 117422, 1172451

Abstract:

A crystallization tray includes a plurality of crystallization cells, each cell having a reservoir adapted to receive an equilibrating solution, a shelf located adjacent to the reservoir and adapted for use as a temporary cryogenic holding area for a crystallized substance and/or a sample holding area, and a sample drop receptacle carried by the shelf and adapted to receive a sample drop including a crystallizable substance. A related method for forming macromolecular crystals includes dispensing an equilibrating solution in the reservoirs, dispensing a plurality of macromolecular solution droplets in the sample drop receptacles, covering the cells with a cover; and crystallizing the crystallizable substance by vapor diffusion.

US Patent:

7364702, Apr 29, 2008

Filed:

Jan 24, 2004

Appl. No.:

10/764710

Inventors:

John Hoffman - Poway CA, US
John A. Adams - Escondido CA, US
Brian L. Ganz - Carlsbad CA, US
David W. Jewell - San Diego CA, US
John Andrew Moulds - Encinitas CA, US
Janet M. Newman - Encinitas CA, US

International Classification:

B01L 3/02

US Classification:

422100, 422 99, 422101, 422102, 2221811, 222548, 436180

Abstract:

A liquid dispensing device. The liquid dispensing device has a tray for holding a liquid at a relatively constant level. A syringe is used for drawing fluid from the tray. A liquid container containing a liquid is positioned upside-down in the tray such that the opening of the liquid container defines a vertical position that is slightly below the liquid level in the tray. Atmospheric pressure on the liquid in the tray and a vacuum inside the liquid container prevents liquid from draining from the container until the fluid level in the tray drops to a level approximately equal to the vertical position of the opening. The positioning of the syringe for drawing fluid is simplified by reason of the fact that the level of fluid in the tray is maintained at an approximately constant level despite withdrawal of quantities of fluid from the tray.

US Patent:

20020067800, Jun 6, 2002

Filed:

Oct 18, 2001

Appl. No.:

10/042929

Inventors:

Janet Newman - Encinitas CA, US
Eric de La Fortelle - Cardiff CA, US

International Classification:

G01N023/207
G01N023/20

US Classification:

378/073000, 378/079000, 378/072000

Abstract:

The apparatus comprises a crystal growing incubator having opposing first and second sides. The apparatus also includes an X-ray system which comprises an X-ray source disposed adjacent to the first side of the crystal growing incubator and an X-ray detector disposed adjacent to the second side of the crystal growing incubator. The X-ray source is configured to irradiate crystalline material grown in the crystal growing incubator and the X-ray detector is configured to detect the presence of diffracted X-rays from crystals grown in the crystal growing incubator. The apparatus preferably further comprises a positioner that positions the incubator and the X-ray system relative to each other. Also provided is a method of screening for crystalline material in its in-situ growth environment using the above described apparatus.

US Patent:

20030105010, Jun 5, 2003

Filed:

Jul 12, 2002

Appl. No.:

10/193858

Inventors:

Janet Newman - Encinitas CA, US
John Badger - San Diego CA, US
Brian Noland - San Diego CA, US
Jorg Hendle - San Diego CA, US
Sean Grant Buchanan - Encinitas CA, US

International Classification:

A61K038/00

US Classification:

514/012000

Abstract:

The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of ArnB amino transferases, and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of ArnB, and compounds and compositions that affect ArnB activity.

US Patent:

6503320, Jan 7, 2003

Filed:

Aug 27, 2001

Appl. No.:

09/942285

Inventors:

Janet Newman - Encinitas CA
Jon A. Christopher - San Diego CA
Brian L. Ganz - Carlsbad CA
James A. Benjamin - Encinitas CA

Assignee:

Structural Genomix, Inc. - San Diego CA

International Classification:

C30B 3118

US Classification:

117 68, 117 69, 117201, 117202, 117927

Abstract:

A blocking device for remote, selective blocking of a cold stream used in a protein crystal annealing process during X-ray protein crystallography includes a blocking member adapted to be selectively moved between at least a blocking position where the blocking member blocks the cold stream and a non-blocking position where the blocking member does not block the cold stream, and an actuation mechanism adapted to impart movement to the blocking member to cause the blocking member to be selectively moved between at least the blocking position and the non-blocking position.