John K Thottathil from Mundelein, IL, age 72

-Lactams, Methods For The Preparation Of Taxanes, And Sidechain-Bearing Taxanes
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US Patent:

6350886, Feb 26, 2002
Filed:

May 12, 1995
Appl. No.:

08/439920
Inventors:

John K. Thottathil - Robbinsville NJ
Ivan D. Trifunovich - Belle Mead NJ
David J. Kucera - Warren NJ
Wen-Sen Li - Lincroft NJ
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D30514
US Classification:

549510, 549511
Abstract:

Novel -lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling -lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

-Lactams, Methods For The Preparation Of Taxanes, And Sidechain-Bearing Taxanes
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US Patent:

6350887, Feb 26, 2002
Filed:

May 12, 1995
Appl. No.:

08/440291
Inventors:

John K. Thottathil - Robbinsville NJ
Ivan D. Trifunovich - Belle Mead NJ
David J. Kucera - Warren NJ
Wen-Sen Li - Lincroft NJ
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D30514
US Classification:

549510, 549511
Abstract:

Novel -lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling -lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

Methods For The Preparation Of Taxanes Using Oxazolidine Intermediates
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US Patent:

6365750, Apr 2, 2002
Filed:

May 20, 1999
Appl. No.:

09/315712
Inventors:

John K. Thottathil - Robbinsville NJ
Ivan D. Trifunovich - Belle Mead NJ
Assignee:

Bristol Myers Squibb Comp. - Princeton NJ
International Classification:

C07D26306
US Classification:

548215, 549510, 549511
Abstract:

Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.

Phosphonooxymethyl Ethers Of Taxane Derivatives
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US Patent:

6455575, Sep 24, 2002
Filed:

Jun 6, 1997
Appl. No.:

08/870794
Inventors:

Jerzy Golik - Southington CT
Dolatrai Vyas - Madison CT
John J. Wright - Guilford CT
Henry Wong - Durham CT
John F. Kadow - Wallingford CT
John K. Thottathil - Robbinsville NJ
Wen-Sen Li - Marlboro NJ
Murray A. Kaplan - Syracuse NY
Robert K. Perrone - Liverpool NY
Mark D. Wittman - Cheshire CT
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

A61K 31337
US Classification:

514449, 549510, 549511
Abstract:

The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Methods For The Preparation Of Taxanes Using Oxazolidine Intermediates
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US Patent:

6784304, Aug 31, 2004
Filed:

Dec 11, 2001
Appl. No.:

10/014950
Inventors:

John K. Thottathil - Robbinsville NJ
Ivan D. Trifunovich - Belle Mead NJ
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D30514
US Classification:

549510, 549511
Abstract:

Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.

Β-Lactams, Methods For The Preparation Of Taxanes, And Sidechain-Bearing Taxanes
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US Patent:

7176326, Feb 13, 2007
Filed:

Oct 20, 2004
Appl. No.:

10/969693
Inventors:

John K. Thottathil - Robbinsville NJ, US
Ivan D. Trifunovich - Belle Mead NJ, US
David J. Kucera - Warren NJ, US
Wen-Sen Li - Lincroft NJ, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C07D 305/00
C07D 407/00
C07D 493/00
C07D 401/00
C07D 405/00
US Classification:

549510, 549511, 546196, 546207, 514449
Abstract:

Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling β-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

Novel Beta-Lactams, Methods For The Preparation Of Taxanes, And Sidechain-Bearing Taxanes
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US Patent:

20020137927, Sep 26, 2002
Filed:

Dec 5, 2001
Appl. No.:

10/006599
Inventors:

John Thottathil - Robbinsville NJ, US
Ivan Trifunovich - Belle Mead NJ, US
David Kucera - Warren NJ, US
Wen-Sen Li - Lincroft NJ, US
International Classification:

C07D205/08
US Classification:

540/354000
Abstract:

Novel -lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling -lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

Taxane Compounds, Compositions And Methods
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US Patent:

20120004429, Jan 5, 2012
Filed:

Jun 28, 2011
Appl. No.:

13/170830
Inventors:

John K. Thottathil - Mundelein IL, US
Assignee:

Genta Incorporated - Berkeley Heights NJ
International Classification:

C07D 317/70
US Classification:

549432
Abstract:

The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.