Kenneth B Murrell

US Patent:

46703845, Jun 2, 1987

Filed:

Dec 18, 1984

Appl. No.:

6/683284

Inventors:

Howard R. Gamble - Bowie MD
Kenneth D. Murrell - Rockville MD

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

G01N 33545
G01N 33569
G01N 33577

US Classification:

435 7

Abstract:

A hybrid cell formed by the fusion of a mouse spleen cell with a mouse myeloma cell secretes an IgM class antibody. The antibody is useful as a preparative reagent in the isolation of three proteins, molecular weights 45,000, 49,000 and 53,000, from the parasite Trichinella spiralis and is also useful as a direct diagnostic reagent is a competitive serodiagnostic test.

US Patent:

47956330, Jan 3, 1989

Filed:

Jul 1, 1987

Appl. No.:

7/068499

Inventors:

Kenneth D. Murrell - Rockville MD
Howard R. Gamble - Bowie MD
Hanspeter Marti - Basel, CH

Assignee:

The United States of America as represented by the Secretary of
Agriculture - Washington DC

International Classification:

A61K 39002
A61K 3900

US Classification:

424 88

Abstract:

A vaccine for immunization of swine against Trichinella spiralis "T. spiralis" wherein the immunogenic substance is inert newborn larvae of T. spiralis emulsified with a suitable adjuvant. The vaccine induces greater than 60% immunity in swine and offers a novel approach to the control of swine trichinosis. Preferably, the inert newborn larvae preparation is emulsified with Freund's complete adjuvant.