Lin Yan

US Patent:

D481962, Nov 11, 2003

Filed:

Sep 11, 2002

Appl. No.:

29/167341

Inventors:

Chun Nan Ou - Shenzhen, CN
GaLei Hu - Shenzhen, CN
Lin Yan - Santa Clara CA
TaiPing Zhou - Santa Clara, CN
Yue Qing Zhao - Shenzhen, CN

Assignee:

Hon Hai Precision Ind. Co., Ltd. - Taipei Hsien

International Classification:

1004

US Classification:

D10 75

US Patent:

7276286, Oct 2, 2007

Filed:

Jul 17, 2001

Appl. No.:

09/907551

Inventors:

Robert G. Chapman - Burlingame CA, US
Emanuele Ostuni - Cambridge MA, US
Michael N. Liang - Somerville MA, US
Lin Yan - East Brunswick NJ, US
George M. Whitesides - Newton MA, US

Assignee:

President & Fellows of Harvard College - Cambridge MA

International Classification:

B32B 9/04
B32B 15/04
B32B 15/08
B32B 27/34

US Classification:

4284111, 428332, 428336, 428338, 428339, 428457, 428458, 4284744

Abstract:

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i. e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

US Patent:

7415710, Aug 19, 2008

Filed:

Jul 7, 2003

Appl. No.:

10/614396

Inventors:

Lin Yan - Bridgewater NJ, US
Roselle Fernandez - Ft. Collins CO, US
Robert Andrew Phillips - Somerville NJ, US
Alberto Bellotti - Hawthorne NJ, US
Janet Gryck - Belle Mead NJ, US
Ingrid M. Holzer - Woodbridge NJ, US

Assignee:

Hewlett-Packard Development Company, L.P. - Houston TX

International Classification:

G06F 3/00

US Classification:

718105, 717168

Abstract:

The invention provides a method and system for maintaining a module type definition table in a computer processing environment. The method includes dynamically creating a module type definition. The method further includes updating a module type definition table to include the module type definition at the direction of the static operating system kernel. A system and article of manufacture for maintaining a module type definition table are also described.

US Patent:

7494714, Feb 24, 2009

Filed:

Jul 9, 2007

Appl. No.:

11/825998

Inventors:

Robert G. Chapman - San Mateo CA, US
Emanuele Ostuni - Flourtown PA, US
Michael N. Liang - London, GB
Lin Yan - Princeton NJ, US
George M. Whitesides - Newton MA, US

Assignee:

President & Fellows of Harvard College - Cambridge MA

International Classification:

B32B 9/04

US Classification:

4284111

Abstract:

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i. e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

US Patent:

7605171, Oct 20, 2009

Filed:

Dec 13, 2004

Appl. No.:

10/575790

Inventors:

Vincent J. Colandrea - North Brunswick NJ, US
George A. Doherty - Superior CO, US
Jeffrey J. Hale - Westfield NJ, US
Pei Huo - Millburn NJ, US
Irene E. Legiec - Mountainside NJ, US
Leslie Toth - Woodbridge NJ, US
Petr Vachal - Summit NJ, US
Lin Yan - East Brunswick NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/443
A61K 31/4245
C07D 413/04
C07D 271/06

US Classification:

514340, 514364, 5462694, 548131

Abstract:

The present invention encompasses compounds of Formula I:.

US Patent:

7659294, Feb 9, 2010

Filed:

Oct 18, 2005

Appl. No.:

11/665046

Inventors:

Jeffrey John Hale - Westfield NJ, US
Lin Yan - East Brunswick NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4245
C07D 271/10
C07D 413/10

US Classification:

514364, 548125, 548131, 548240, 548251, 548255, 5462681, 5462684, 5462694, 544224, 544242, 544336, 514361, 514378, 514381, 514385

Abstract:

The present invention encompasses compounds of Formula I:.

US Patent:

7999107, Aug 16, 2011

Filed:

Jan 16, 2008

Appl. No.:

12/009114

Inventors:

John S. Debenham - Scotch Plains NJ, US
Jeffrey J. Hale - Westfield NJ, US
Pei Huo - Millburn NJ, US
Thomas F. Walsh - Watchung NJ, US
Lin Yan - East Brunswick NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 491/052
A61K 31/436

US Classification:

546115, 546116, 514302

Abstract:

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.

US Patent:

8119806, Feb 21, 2012

Filed:

Jul 27, 2009

Appl. No.:

12/509698

Inventors:

Amjad Ali - Freehold NJ, US
Iyassu K. Sebhat - Jersey City NJ, US
Christopher L. Franklin - Quincy MA, US
Kathleen M. Rupprecht - Cranford NJ, US
Robert K. Baker - Cranford NJ, US
Ravi P. Nargund - East Brunswick NJ, US
Lin Yan - East Brunswick NJ, US
Pei Huo - Millburn NJ, US
Nicoletta Almirante - Milan, IT
Stefano Biondi - Pero, IT
Massimiliano Ferrario - Ceriano Laghetto, IT
Alessia Nicotra - Grandate, IT

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/4355
C07D 491/048

US Classification:

546115, 514302

Abstract:

A compound having the structure.