Manuel V Medina

US Patent:

20150285685, Oct 8, 2015

Filed:

Apr 9, 2015

Appl. No.:

14/683066

Inventors:

- Durham NC, US
Howard Levinson - San Diego CA, US
William J. Brown - Durham NC, US
Thomas Matthews - Durham NC, US
Manuel Medina - Durham NC, US

International Classification:

G01J 3/28
G01J 3/453
G01N 21/25
G01B 9/02

Abstract:

Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an illumination beam, an interferometer, and a spectrometer. The interferometer includes a first beam splitter configured to split the illumination beam into an incident beam and a reference beam; an optical lens directs the incident beam onto a biological sample at a predefined offset from corresponding optical axis, and receive a beam scattered from the biological sample. The beams are configured to intersect with each other within a focal zone of the optical lens. Photons of the incident beam undergo multiple forward scattering within the biological sample. A second beam splitter configured to receive and superimpose the scattered and reference beams, to generate an interference beam. The spectrometer uses a spectral domain detection technique to assess tissue properties of the biological sample.