Mark A Burns

US Patent:

6646149, Nov 11, 2003

Filed:

May 31, 2000

Appl. No.:

09/584175

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA 98072
Christine L. ODay - Mountlake Terrace WA 98043
Heather K. Webb - Seattle WA 98107
Mark R. Burns - Shoreline WA 98177
Donald E. Bergstrom - West Lafayette IN 47906

International Classification:

C07C27112

US Classification:

560 25, 549 65, 549560, 564 83, 564 84, 564215, 514269, 514270, 514290, 514299, 514354, 514361, 514378, 514445, 514468, 514478, 514520, 514561, 514602, 514616, 514629, 514673, 514674, 544300, 546101, 546152, 548127, 548248, 548537, 558411

Abstract:

Novel âbispolyamineâ inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. These compounds display desirable activities both for diagnostic and research assays and therapy.

US Patent:

6872852, Mar 29, 2005

Filed:

Mar 23, 2001

Appl. No.:

10/239521

Inventors:

Mark R. Burns - Shoreline WA, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA

International Classification:

C07C211/09
C07C211/13
A61K031/135

US Classification:

564306, 564338, 564367, 564372, 514649, 514650

Abstract:

Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury.

US Patent:

6914079, Jul 5, 2005

Filed:

Sep 23, 2002

Appl. No.:

10/251819

Inventors:

Mark R. Burns - Shoreline WA, US
Gerard F. Graminski - Shoreline WA, US

Assignee:

MediQuest Therapeutics, Inc. - Seattle WA

International Classification:

A61K031/135
C07C211/27

US Classification:

514646, 514645, 564305, 564306, 564336

Abstract:

Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

US Patent:

6963010, Nov 8, 2005

Filed:

Jan 8, 2002

Appl. No.:

10/296259

Inventors:

Mark R. Burns - Shoreline WA, US
Gerard F. Graminski - Shoreline WA, US

Assignee:

MediQuest Therapeutics, Inc. - Seattle WA

International Classification:

C07C233/05
A61K031/16

US Classification:

564152, 564 84, 564 86, 564 98, 564155, 564159, 564188, 564198, 549487, 549488, 514601, 514602, 514603, 514605, 514616, 514623, 514626, 514461

Abstract:

The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.

US Patent:

7144920, Dec 5, 2006

Filed:

Mar 29, 2004

Appl. No.:

10/810649

Inventors:

Mark R. Burns - Shoreline WA, US
Gerard F. Graminski - Shoreline WA, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA

International Classification:

A61K 31/135
C07D 211/18

US Classification:

514649, 564336

Abstract:

Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by omithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

US Patent:

7160923, Jan 9, 2007

Filed:

Nov 14, 2000

Appl. No.:

09/713512

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA, US
Christine L. O'Day - Mountlake Terrace WA, US
Heather K. Webb - Seattle WA, US
Mark R. Burns - Shoreline WA, US
Donald E. Bergstrom - West Lafayette IN, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA

International Classification:

A61K 31/27
A61K 31/18
A61K 31/165
A61K 31/17
A61K 31/34

US Classification:

514626, 514311, 514365, 514378, 514423, 514445, 514471, 514481, 514596, 514602, 514603, 514616, 514617, 514625, 544144, 548200, 548243, 5483251, 548536, 549479, 560157, 564 48, 564 80, 564 83, 564 84, 564 86, 564161, 564180, 564197

Abstract:

Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatiorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

US Patent:

7199267, Apr 3, 2007

Filed:

Oct 21, 2005

Appl. No.:

11/254743

Inventors:

Mark R. Burns - Kenmore WA, US
Sunil A. David - Lawrence KS, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA
The University of Kansas - Lawrence KS

International Classification:

C07C 233/01

US Classification:

564152

Abstract:

Small molecule polycationic agents are used to modulate or interrupt biological processes by binding to oligosaccharide-based biomolecules. Compounds that inhibit nitric oxide, TNFα or other immunomodulators are provided and are useful for treating immunological disease and disease of an infectious disorder.

US Patent:

7208528, Apr 24, 2007

Filed:

Sep 15, 1999

Appl. No.:

09/396523

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA, US
Christine L. O'Day - Mountlake Terrace WA, US
Heather K. Webb - Seattle WA, US
Mark R. Burns - Shoreline WA, US
Donald E. Bergstrom - West Lafayette IN, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA

International Classification:

A61K 31/47
A61K 31/425
A61K 31/42
A61K 31/17
A61K 31/16

US Classification:

514626, 514311, 514365, 514378, 514423, 514445, 514471, 514481, 514596, 514602, 514603, 514616, 514617, 514625, 544144, 548200, 548248, 5483751, 548536, 549479, 560157, 564197, 564 48, 564 80, 564 83, 564 84, 564 86, 564161, 564180

Abstract:

Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinational polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.