Mark J Friedman

US Patent:

48717762, Oct 3, 1989

Filed:

Oct 22, 1987

Appl. No.:

7/112260

Inventors:

Michael J. DiNovi - Philadelphia PA
Robert J. Rafka - Groton Long Point CT
Mark I. Friedman - Merion PA
Michael G. Tordoff - Philadelphia PA

Assignee:

Monell Chemical Senses Center - Philadelphia PA

International Classification:

A61K 31045

US Classification:

514738

Abstract:

A novel fructose analog is disclosed which has been found to modify the food intake of mammals. If administered during the diurnal fasting period, the mammals increase their food intakes. If administered during the diurnal feeding period, food intake is decreased. The compound is 2,5-anhydro-1,6-dihalo-1,6-dideoxy-D-mannitol, preferably 2,5-anhydro-1,6-dichloro-dideoxy-D-mannitol ("Charmitol").

US Patent:

48086266, Feb 28, 1989

Filed:

Sep 23, 1986

Appl. No.:

6/910698

Inventors:

Mark I. Friedman - Merion PA
Michael G. Tordoff - Philadelphia PA
Michael J. DiNovi - Philadelphia PA
Robert J. Rafka - Ardmore PA

Assignee:

Monell Chemical Senses Center - Philadelphia PA

International Classification:

A61K 31045

US Classification:

514738

Abstract:

A novel method for altering the food intake of a mammal is disclosed wherein 2,5-anhydro-D-mannitol (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperitoneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the lower limit of sufficiently nor the upper limit of activity have yet to be identified.

US Patent:

49545310, Sep 4, 1990

Filed:

Aug 15, 1988

Appl. No.:

7/231941

Inventors:

Mark I. Friedman - Merion PA
Michael G. Tordoff - Philadelphia PA
Michael J. DiNovi - Philadelphia PA
Robert J. Rafka - Ardmore PA

Assignee:

Monell Chemical Senses Center - Philadelphia PA

International Classification:

A61K 31045

US Classification:

514738

Abstract:

A novel method for altering the food intake of a mammal is diclosed wherein 2,5-anhydro-D-mannito (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperitoneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the low limit of sufficiency nor the upper limit of activity have yet to be identified.