Pratiksha C Patel

US Patent:

7241592, Jul 10, 2007

Filed:

Mar 19, 2001

Appl. No.:

09/810428

Inventors:

Magnus Hook - Houston TX, US
Yi Xu - Houston TX, US
Pietro Speziale - Pavia, IT
Livia Visal - Rosate, IT
Fabrizia Casolini - Sondalo, IT
Joseph M. Patti - Cumming GA, US
Pratiksha Patel - Duluth GA, US
Paul Domanski - Atlanta GA, US

Assignee:

Universita Degli Studi di Pavia - Pavia
The Texas A&M University System - College Station TX
Inhibitex, Inc. - Alpharetta GA

International Classification:

C12P 21/08
C12N 1/00
A61K 39/395
A61K 39/40
C07K 16/12

US Classification:

435 697, 435340, 435332, 435331, 435326, 530350, 5303871, 5303881, 5303884, 4241301, 4241311, 4241331, 4241341, 4241371, 4241381, 4241411, 4241761, 4241771, 4242371, 4241391, 4241501, 4241651

Abstract:

Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both and bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.