Qian F Zhang

US Patent:

20220306758, Sep 29, 2022

Filed:

May 31, 2022

Appl. No.:

17/828847

Inventors:

- Tarrytown NY, US
Kara Olson - White Plains NY, US
Frank Delfino - Poughquag NY, US
David DiLillo - New York NY, US
Jessica Kirshner - New York NY, US
Olga Sineshchekova - Pleasantville NY, US
Qian Zhang - Lexington MA, US

International Classification:

C07K 16/28
C07K 16/46

Abstract:

B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides novel bispecific antibodies (bsAbs) that bind to both BCMA and CD3 and activate T cells via the CD3 complex in the presence of BCMA-expressing tumor cells. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of various cancers, including multiple myeloma.

US Patent:

20210376905, Dec 2, 2021

Filed:

May 11, 2021

Appl. No.:

17/317694

Inventors:

- San Diego CA, US
Jung Ho RYU - Fort Lee NJ, US
Qian ZHANG - Basking Ridge NJ, US
Navid ABEDINI - Basking Ridge NJ, US
Tao LUO - San Diego CA, US

International Classification:

H04B 7/06
H04W 24/10
H04L 5/14
H04W 72/04

Abstract:

Aspects described herein relate to autonomously measuring one or more new candidate beam pairs during configured resources to determine measurement results for the one or more new candidate beam pairs, where the configured resources can be configured for uplink communications or measurement gaps for transmitting signals to measure candidate beams. A measurement result or an indication of at least one new candidate beam pair can be reported based on a measurement result for the at least one new candidate beam pair of the one or more new candidate beam pairs.

US Patent:

20210136614, May 6, 2021

Filed:

Jan 12, 2021

Appl. No.:

17/146539

Inventors:

- Wilmington DE, US
Pascal M. Adjakple - Great Neck NY, US
Wei Chen - San Diego CA, US
Lakshmi R. Iyer - King of Prussia PA, US
Qian Zhang - Basking Ridge NJ, US
Guodong Zhang - Woodbury NY, US
Allan Y. Tsai - Boonton NJ, US

International Classification:

H04W 24/10
H04B 7/06
H04B 7/0408
H04B 7/0456
H04L 5/00
H04W 16/28
H04W 72/04
H04W 80/02

Abstract:

Layer 2 structures and procedures may be used for beam management in new radio networks. In a first example, a new radio layer 2 structure may be used to facilitate beam management at the medium access control sublayer. In a second example, new radio feedback mechanisms may be signaled between peer medium access control entities and used to assist with beam management. In a third example, new radio beam management procedures may include new radio beam training, new radio beam alignment, new radio beam tracking, or new radio beam configuration. In a fourth example, new radio connection control procedure may include new radio initial access or new radio mobility management.

US Patent:

20210126749, Apr 29, 2021

Filed:

Nov 5, 2020

Appl. No.:

17/090189

Inventors:

- Wilmington DE, US
Guodong Zhang - Woodbury NY, US
Qian Zhang - Basking Ridge NJ, US
Allan Y. Tsai - Boonton NJ, US
Joseph M. Murray - Schwenksville PA, US
Pascal M. Adjakple - Great Neck NY, US
Qing Li - Princeton Junction NJ, US
Tianyi Xu - San Jose CA, US
Wei Chen - San Diego CA, US
Ahmed ElSamadouny - Austin TX, US
Salman Khan - Richardson TX, US
Yifan Li - Conshohocken PA, US

International Classification:

H04L 5/00
H04L 1/00
H04L 1/18
H04B 7/0456
H04B 7/06

Abstract:

Flexibly configured containers consisting of resources within time-frequency blocks may be used to support multiple numerologies in new radio architectures. Uplink control may be defined in resources within a container, or in dedicated resources, by various nodes.Sounding reference signal resources may be dynamically configured for each numerology. The sequence length may be adapted, as well as the time domain location of symbols. Time, frequency, and orthogonal resources may be allocated via a downlink control channel or a radio resource control.Sounding reference signals may be pre-coded, and pre-coding weights may be based on a codebook or non-codebook approaches, e.g., via a radio resource control or a downlink RRC or DL control channel. Pre-coded sounding reference signals may be adapted to user equipment antenna configuration. Further, NR-SRS may be used as UL demodulation RS (DM-RS).

US Patent:

20200382189, Dec 3, 2020

Filed:

Aug 18, 2020

Appl. No.:

16/996364

Inventors:

- Wilmington DE, US
Pascal Adjakple - Great Neck NY, US
Joseph M. Murray - Schwenksville PA, US
Qing Li - Princeton Juction NJ, US
Qian Zhang - Basking Ridge NJ, US
Lakshmi R. Iyer - King of Prussia PA, US
Tianyi Xu - San Jose CA, US
Guodong Zhang - Woodbury NY, US
Allan Tsai - Boonton NJ, US

International Classification:

H04B 7/06
H04W 16/28
H04W 48/20
H04W 72/04

Abstract:

Multiple mobility sets are maintained for nodes of radio networks. The sets comprise information such as: transmit and receive point identities; cell identities; beam identities; frequency channels; channel bandwidth; and black lists. The sets may be defined at different levels, such as network and physical (PHY) level. A network mobility set, e.g., a new-radio (NR) mobility set may, be determined by the gNB, the cell, the UE, or another device. Multiple radio access network nodes and UEs may exchange mobility set information to achieve a distributed mobility solution. A UE may monitor its orientation relative to a TRP, e.g., via use of an onboard MEMS gyroscope, and alter its beamforming parameters in response to changes in orientation and/or changes in TRP connection strength. Cell selection and reselection for beam based networks may use Single Frequency Network (SFN) broadcast of initial access signals without beam sweeping.

US Patent:

20200252976, Aug 6, 2020

Filed:

Mar 4, 2020

Appl. No.:

16/808849

Inventors:

- Wilmington DE, US
Pascal M. Adjakple - Great Neck NY, US
Wei CHEN - San Diego CA, US
Lakshmi R. Iyer - King of Prussia PA, US
Qian (Emily) Zhang - Basking Ridge NJ, US
Allan Y. Tsai - Boonton NJ, US
Guodong Zhang - Woodbury NY, US
Qing Li - Princeton Junction NJ, US

International Classification:

H04W 74/08
H04B 7/08
H04B 7/06
H04L 5/00
H04B 7/26
H04W 72/04

Abstract:

The present application is at leasted directed to an apparatus including a non-transitory memory including instructions to perform random access in a beam sweeping network having a cell. The network includes a downlink sweeping subframe, an uplink sweeping subframe and a regular sweeping subframe. The apparatus also includes a processor operably coupled to the non-transitory memory. The processor is configured to execute the instructions of selecting an optimal downlink transmission beam transmitted by the cell during the downlink sweeping subframe. The processor is also configured to execute the instructions of determining an optimal downlink reception beam from the optimal downlink transmission beam. The processor is further configured to execute the instructions of determining a random access preamble and a physical random access channel (PRACH) resource via resource selection from the optimal downlink transmission beam.

US Patent:

20200240965, Jul 30, 2020

Filed:

Jan 23, 2020

Appl. No.:

16/750287

Inventors:

- Tarrytown NY, US
Qian Zhang - Tarrytown NY, US

International Classification:

G01N 30/72
B01J 20/281
G01N 30/80
G01N 30/38
G01N 30/74
G01N 33/68

Abstract:

Methods and system for protein characterization using online chromatography and electrospray ionization mass spectrometry are provided.

US Patent:

20200221480, Jul 9, 2020

Filed:

Mar 20, 2020

Appl. No.:

16/825516

Inventors:

- Wilmington DE, US
Guodong Zhang - Woodbury NY, US
Pascal M. Adjakple - Great Neck NY, US
Lakshmi R. Iyer - King of Prussia PA, US
Allan Y. Tsai - Boonton NJ, US
Qian Zhang - Basking Ridge NJ, US
Wei Chen - San Diego CA, US
Joseph M. Murray - Schwenksville PA, US
Tianyi Xu - San Jose CA, US

International Classification:

H04W 72/12
H04W 74/08
H04L 1/18
H04L 5/00
H04W 4/70

Abstract:

Current approaches to transmitting uplink data in a network often require resources to be granted. In an example, a node or apparatus may configure a plurality of devices to operate in a grant-less mode in accordance with a respective grant-less access allocation, such that, when the plurality of devices transmit messages uplink in the network, the messages are transmitted using frequency resources defined by the respective grant-less access allocation, and the plurality of devices transmit the messages without being granted access to transmit the messages, so as to operate in the grant-less mode.