Thomas Leon Neff

US Patent:

6839762, Jan 4, 2005

Filed:

May 16, 2000

Appl. No.:

09/571197

Inventors:

Zengpin Yu - Palo Alto CA, US
Eddy Ye - San Jose CA, US
Thomas P. Neff - Newark CA, US

Assignee:

U-Systems, Inc. - Los Altos CA

International Classification:

G06F 1516

US Classification:

709230, 709232

Abstract:

An ultrasound information processing system comprises a plurality of ultrasound devices coupled to a high-speed serial ultrasound information bus, wherein each ultrasound device comprises a program for communicating with other ultrasound devices according to an ultrasound information exchange protocol (UIEP). The UIEP is a lightweight, connection-oriented protocol adapted to efficiently transfer ultrasound information among different devices on the ultrasound information bus. Each ultrasound device comprises an application layer program for performing an ultrasound function, as well as a lower protocol layer program for receiving and sending data across the ultrasound information bus according to a high-speed serial bus standard that provides both isochronous and asynchronous data delivery. The ultrasound information exchange protocol (UIEP) program is adapted to receive a communication request from the application layer, open a connection-oriented communication session with the requested ultrasound device, and transfer ultrasound information through the lower protocol layer and across the ultrasound information bus to the requested device. Advantageously, any ultrasound device manufacturer provided with the UIEP program may readily generate application layer code capable of communicating with other manufacturers' ultrasound devices across the ultrasound information bus, without requiring specific knowledge of the internal structure of the other manufacturers' devices or of the specific frame/packet structure of the UIEP/lower layer protocols themselves.

US Patent:

6992172, Jan 31, 2006

Filed:

Nov 10, 2000

Appl. No.:

09/710239

Inventors:

Robert C. Chang - Burlingame CA, US
Kari I. Kivirikko - Oulu, FI
Thomas B. Neff - Atherton CA, US
David R. Olsen - Menlo Park CA, US
James W. Polarek - Sausalito CA, US

Assignee:

FibroGen, Inc. - South San Francisco CA

International Classification:

A61K 38/17
C09H 3/00

US Classification:

530354, 530350, 536 231, 435 691, 4353201, 435325

Abstract:

The present invention relates to recombinant gelatins and compositions thereof, and methods of producing and using the same.

US Patent:

7393928, Jul 1, 2008

Filed:

May 27, 2005

Appl. No.:

11/139377

Inventors:

Robert C. Chang - Burlingame CA, US
Kari I. Kivirikko - Oulu, FI
Thomas B. Neff - Atherton CA, US
David R. Olsen - Menlo Park CA, US
James W. Polarek - Sausalito CA, US

Assignee:

FibroGen, Inc. - South San Francisco CA

International Classification:

A61K 38/17
C09H 3/00

US Classification:

530354, 530350, 536 231, 435 691, 4353201, 435325

Abstract:

The present invention relates to recombinant gelatins and compositions thereof, and methods of producing and using the same.

US Patent:

7405274, Jul 29, 2008

Filed:

Jun 1, 2004

Appl. No.:

10/858186

Inventors:

Al Y. Lin - Castro Valley CA, US
Thomas B. Neff - Atherton CA, US
Noelynn A. Oliver - Los Altos CA, US
William R. Usinger - Lafayette CA, US
Qingjian Wang - Belmont CA, US
David A. Yeowell - San Francisco CA, US

Assignee:

FibroGen, Inc. - South San Francisco CA

International Classification:

C12P 21/08
C07K 16/00

US Classification:

5303871, 5303873, 5303881, 53038823

Abstract:

The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.

US Patent:

7615008, Nov 10, 2009

Filed:

Nov 23, 2004

Appl. No.:

10/997293

Inventors:

Wei Zhang - Union City CA, US
Shih-Ping Wang - Los Altos CA, US
Jiayu Chen - Palo Alto CA, US
Zengpin Yu - Palo Alto CA, US
Tommy Earl Cupples - Columbia SC, US
Thomas P. Neff - Newark CA, US
Michael E. Reed - Sunnyvale CA, US

Assignee:

U-Systems, Inc. - San Jose CA

International Classification:

A61B 8/00

US Classification:

600437, 600443, 600444, 600461, 382128

Abstract:

Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.

US Patent:

7618940, Nov 17, 2009

Filed:

Dec 4, 2003

Appl. No.:

10/729167

Inventors:

Patrick D. Fourney - Walnut Creek CA, US
Stephen J. Klaus - San Francisco CA, US
Al Y. Lin - Castro Valley CA, US
Thomas B. Neff - Atherton CA, US
Todd W. Seeley - Moraga CA, US

Assignee:

FibroGen, Inc. - San Francisco CA

International Classification:

C12Q 1/37

US Classification:

514 3, 435 23

Abstract:

The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e. g. , obesity, diabetes, atherosclerosis, etc.

US Patent:

7727151, Jun 1, 2010

Filed:

May 23, 2006

Appl. No.:

11/439093

Inventors:

Wei Zhang - Union City CA, US
Jiayu Chen - Palo Alto CA, US
Thomas P. Neff - Newark CA, US
Michael E. Reed - Sunnyvale CA, US
Jeanine M. Rader - Rockford IL, US

Assignee:

U-Systems Inc. - Sunnyvale CA

International Classification:

A61B 8/00

US Classification:

600443, 600437

Abstract:

Navigation among breast ultrasound volumes derived from different volumetric ultrasonic scans of a same breast is described. On a display of a breast ultrasound workstation, a first image derived from a first ultrasonic volume is displayed. A user selection of a source region of interest (ROI) in the first image is received. A destination ROI within a second ultrasonic volume is identified that at least roughly corresponds to a same locality of tissue in the breast as the source ROI. A second image derived from the second ultrasonic volume and including the destination ROI is displayed, the destination ROI being highlighted.

US Patent:

7828733, Nov 9, 2010

Filed:

Aug 21, 2009

Appl. No.:

12/545201

Inventors:

Wei Zhang - Union City CA, US
Shih-Ping Wang - Los Altos CA, US
Jiayu Chen - Palo Alto CA, US
Zengpin Yu - Palo Alto CA, US
Tommy Earl Cupples - Columbia SC, US
Thomas P. Neff - Newark CA, US
Michael E. Reed - Sunnyvale CA, US

Assignee:

U-Systems Inc. - San Jose CA

International Classification:

A61B 8/00

US Classification:

600437, 600443, 600444, 600461, 382128

Abstract:

Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.