Vincent Ray Hernandez

US Patent:

6673550, Jan 6, 2004

Filed:

Nov 9, 2001

Appl. No.:

10/008495

Inventors:

Tracy Matray - San Lorenzo CA
Vincent Hernandez - Brookdale CA
Sharat Singh - San Jose CA

Assignee:

Aclara Biosciences, Inc. - Mountain View CA

International Classification:

C12Q 168

US Classification:

435 6, 435 912, 536 243, 536 2532

Abstract:

Electrophoretic probes comprising fluorescent compounds as detection groups and mobility modifiers are disclosed for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. In one embodiment, detection involves the release of identifying tags as a consequence of target recognition. Target antiligands are contacted with a set of e-tag probes and the contacted antiligands are treated with a selected cleaving agent resulting in a mixture of e-tag reporters. Typically, uncleaved or partially cleaved e-tag probes are removed and the mixture of e-tag reporters is separated by any technique that provides for separation by mass or mass to charge ratio and the like and detected to provide for target identification.

US Patent:

7255999, Aug 14, 2007

Filed:

May 21, 2002

Appl. No.:

10/154042

Inventors:

Sharat Singh - San Jose CA, US
Syed Hasan Tahir - Foster City CA, US
Gerald J. Wallweber - Woodside CA, US
Hrair Kirakossian - San Jos CA, US
Tracy J. Matray - San Lorenzo CA, US
Vincent S. Hernandez - Brookdale CA, US

Assignee:

Monogram Biosciences, Inc. - South San Francisco CA

International Classification:

G01N 33/53
G01N 33/533
C12Q 1/42

US Classification:

435 71, 435 772, 435 795, 435 21, 436546, 436161

Abstract:

Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and a first binding agent for a binding site on a target polypeptide is subjected to conditions under which binding of respective binding moieties occurs. The binding site is the result of post-translational modification activity involving the target polypeptide. The method may be employed to determine the target polypeptide itself. In another embodiment the presence and/or amount of the target polypeptide is related to the presence and/or amount and/or activity of an agent such as an enzyme involved in the post-translational modification of the target polypeptide. The interaction between the first binding agent and the binding site brings the cleavage-inducing moiety into close proximity to a cleavable moiety, which is associated with the polypeptide and is susceptible to cleavage only when in proximity to the cleavage-inducing moiety. In this way, an electrophoretic tag for each of the polypeptides may be released.

US Patent:

7582621, Sep 1, 2009

Filed:

Feb 16, 2006

Appl. No.:

11/357687

Inventors:

Stephen J. Baker - Mountain View CA, US
Tsutomu Akama - Sunnyvale CA, US
Vincent S. Hernandez - Watsonville CA, US
Karin M. Hold - Belmont CA, US
James J. Leyden - Malvern PA, US
Kirk R. Maples - San Jose CA, US
Jacob J. Plattner - Berkeley CA, US
Virginia Sanders - San Francisco CA, US
Yong-Kang Zhang - San Jose CA, US

Assignee:

Anacor Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 31/69
C07F 5/04

US Classification:

514 64, 558288

Abstract:

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

US Patent:

7767657, Aug 3, 2010

Filed:

Aug 16, 2006

Appl. No.:

11/505591

Inventors:

Stephen J. Baker - Mountain View CA, US
Tsutomu Akama - Sunnyvale CA, US
Vincent S. Hernandez - Watsonville CA, US
Karin M. Hold - Belmont CA, US
Kirk R. Maples - San Jose CA, US
Jacob J. Plattner - Berkeley CA, US
Virginia Sanders - San Francisco CA, US
Yong-Kang Zhang - San Jose CA, US
Gregory Fieldson - Morgantown WV, US

Assignee:

Anacor Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 31/69

US Classification:

514 64, 558288

Abstract:

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

US Patent:

7816344, Oct 19, 2010

Filed:

Jun 19, 2008

Appl. No.:

12/142692

Inventors:

Stephen J. Baker - Mountain View CA, US
Vincent S. Hernandez - Watsonville CA, US
Rashmi Sharma - Edmonton, CA
James A. Nieman - Sherwood Park, CA
Tsutomu Akama - Sunnyvale CA, US
Yong-Kang Zhang - San Jose CA, US
Jacob J. Plattner - Berkeley CA, US
Michael Richard Kevin Alley - Santa Clara CA, US
Rajeshwar Singh - Edmonton, CA
Fernando Rock - Los Altos CA, US

Assignee:

Anacor Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 31/69
C07D 493/00

US Classification:

514 64, 549213

Abstract:

This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating bacterial infections, pharmaceutical compositions containing such oxaboroles, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.

US Patent:

8039451, Oct 18, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507010

Inventors:

Stephen J. Baker - Mountain View CA, US
Tsutomu Akama - Sunnyvale CA, US
Vincent S. Hernandez - Watsonville CA, US
Karin M. Hold - Belmont CA, US
James J. Leyden - Malvern PA, US
Kirk Maples - San Jose CA, US
Jacob J. Plattner - Berkeley CA, US
Virginia Sanders - San Francisco CA, US
Yong-Kang Zhang - San Jose CA, US

Assignee:

Anacor Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 31/69
C07F 5/04

US Classification:

514 64, 558288

Abstract:

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

US Patent:

8115026, Feb 14, 2012

Filed:

Dec 2, 2009

Appl. No.:

12/629753

Inventors:

Stephen J. Baker - Mountain View CA, US
Tsutomu Akama - Sunnyvale CA, US
Michael Richard Kevin Alley - Santa Clara CA, US
Steven J. Benkovic - State College PA, US
Michael DiPierro - Wadsworth IL, US
Vincent S. Hernandez - Watsonville CA, US
Karin M. Hold - Belmont CA, US
Isaac Kennedy - Bolingbrook IL, US
Igor Likhotvorik - Naperville IL, US
Weimin Mao - Sunnyvale CA, US
Kirk R. Maples - San Jose CA, US
Jacob J. Plattner - Berkeley CA, US
Fernando Rock - Los Altos CA, US
Virginia Sanders - San Francisco CA, US
Aaron M. Stemphoski - Florence SC, US
George Petros Yiannikouros - Florence SC, US
Siead Zegar - Orland Park IL, US
Yong-Kang Zhang - San Jose CA, US
Huchen Zhou - Shanghai, CN

Assignee:

Anacor Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

C07F 5/04

US Classification:

558288

Abstract:

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

US Patent:

8168614, May 1, 2012

Filed:

Feb 16, 2007

Appl. No.:

11/676120

Inventors:

Stephen J. Baker - Mountain View CA, US
Virginia Sanders - San Francisco CA, US
Tsutomu Akama - Sunnyvale CA, US
Yvonne Freund - Los Altos CA, US
Kirk R. Maples - San Jose CA, US
Jacob J. Plattner - Berkeley CA, US
Yong-Kang Zhang - San Jose CA, US
Huchen Zhou - Shanghai, CN
Vincent S. Hernandez - Watsonville CA, US

Assignee:

Anacor Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 31/69

US Classification:

514 64

Abstract:

Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.