Vladimir Z Gurevich

US Patent:

59654341, Oct 12, 1999

Filed:

Dec 29, 1994

Appl. No.:

8/365841

Inventors:

Jon A. Wolff - Madison WI
Vladimir Budker - Madison WI
Vladimir Gurevich - Madison WI

International Classification:

C12N 1563

US Classification:

4353201

Abstract:

The present invention provides amphipathic lipid compounds comprising a hydrophilic, catonic, pH-sensitive moiety, the positive charge of which moiety increases as pH decreases over the pH range of 8. 0 to 4. 5. Vesicular delivery systems comprising such amphipathic compounds and the use of those systems for delivering biologically active substances to cells are also provided.

US Patent:

56354878, Jun 3, 1997

Filed:

Dec 29, 1994

Appl. No.:

8/368150

Inventors:

Jon A. Wolff - Madison WI
Vladimir Budker - Madison WI
Vladimir Gurevich - Madison WI

International Classification:

A61K 4800
A61K 3166
A61K 31415

US Classification:

514 44

Abstract:

The present invention provides a composition comprising a population of micelles wherein each micelle comprises at least one amphipathic compound layer that surrounds a non-aqueous core that contains a polyion. Also provided are a method of preparing such a composition and the uses of such compositions for delivering biologically active polyions to cells.

US Patent:

61243523, Sep 26, 2000

Filed:

Jul 27, 1994

Appl. No.:

8/281246

Inventors:

Vladimir Z. Gurevich - Madison WI

Assignee:

Jemlan, LLC - Madison WI

International Classification:

A61K 31265
A61K 3121

US Classification:

514512

Abstract:

A method of treating fungal diseases as well as pharmaceutical, veterinary and agricultural compositions useful in such treatment. The method includes administering an effective antifungal amount of a compound of the formula (I): ##STR1## wherein S is a spacer selected from a nitrogen, an oxygen, an alkyl, an alkenyl, an alcohol, an ester, a polyester, an amino acid, a carbohydrate, or a nitrogen-containing positively charged group; L is a ligand selected from a hydrogen, a hydroxyl residue, an alkyl residue, an alkenyl residue, a benzyl residue, an alcohol residue, an ester residue, a polyester residue, an alkyl acid residue, a carbohydrate, a steroid, a lipid, an organic polymer, a nitrogen-containing positively charged group or a vitamin; R. sub. 1 and R. sub. 3 are halogen or hydroxyl; and R. sub. 2 is hydrogen or alkyl.