Walter Morozowich

US Patent:

6451838, Sep 17, 2002

Filed:

May 24, 2001

Appl. No.:

09/863905

Inventors:

Malcolm Wilson Moon - Kalamazoo MI
Walter Morozowich - Kalamazoo MI
Ping Gao - Portage MI

Assignee:

Pharmacia Upjohn company - Kalamazoo MI

International Classification:

A61K 31403

US Classification:

514414, 548468

Abstract:

The present invention is directed to 1-pyrrolidin-1-ylmethyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (âPKsâ). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

US Patent:

6482848, Nov 19, 2002

Filed:

May 24, 2001

Appl. No.:

09/863819

Inventors:

Malcolm Wilson Moon - Kalamazoo MI
Walter Morozowich - Kalamazoo MI
Ping Gao - Portage MI
Marcel Koenig - Burlingame CA

Assignee:

Sugen Incorporated - South San Francisco CA

International Classification:

C07D20910

US Classification:

514418, 548467, 548468, 548486

Abstract:

The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (âPKsâ). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

US Patent:

6531139, Mar 11, 2003

Filed:

Jul 27, 1998

Appl. No.:

09/122926

Inventors:

Ping Gao - Portage MI
Walter Morozowich - Kalamazoo MI

Assignee:

Pharmacia Upjohn Company - Kalamazoo MI

International Classification:

A61K 948

US Classification:

424400, 424451, 424455, 424456, 514 2, 514 9, 514169, 514315, 514336, 514456, 514459, 514460, 514557, 514558, 514560, 514573, 514937, 514 11

Abstract:

The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di- unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.

US Patent:

6710067, Mar 23, 2004

Filed:

May 24, 2001

Appl. No.:

09/863804

Inventors:

Malcolm Wilson Moon - Kalamazoo MI
Walter Morozowich - Kalamazoo MI
Ping Gao - Portage MI
Peng Cho Tang - Moraga CA

Assignee:

Sugen Incorporated - South San Francisco CA
Pharmacia UpJohn Company - Kalamazoo MI

International Classification:

A61K 314045

US Classification:

514414, 548468

Abstract:

The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (âPKsâ). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

US Patent:

6716870, Apr 6, 2004

Filed:

Sep 16, 2002

Appl. No.:

10/243942

Inventors:

Malcolm Wilson Moon - Kalamazoo MI
Walter Morozowich - Kalamazoo MI
Ping Gao - Portage MI
Marcel Koenig - Burlingame CA

Assignee:

Sugen, Inc. - South San Francisco CA
Pharmacia Upjohn Company - Kalamazoo MI

International Classification:

A61K 31401

US Classification:

514418, 548467, 548468, 548486

Abstract:

The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (âPKsâ). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

US Patent:

6890920, May 10, 2005

Filed:

Oct 25, 2002

Appl. No.:

10/280906

Inventors:

Ivan Richards - Kalamazoo MI, US
Sue K. Cammarata - Portage MI, US
Craig D. Wegner - Mundelein IL, US
Michael Hawley - Kalamazoo MI, US
Mark Peter Warchol - Kalamazoo MI, US
Mark Kontny - Libertyville IL, US
Walter Morozowich - Kalamazoo MI, US
Karen Patrice Kolbasa - Schoolcraft MI, US
Malcolm Wilson Moon - Kalamazoo MI, US
Dominique Bonafoux - St. Louis MO, US
Sergey Gregory Wolfson - Chesterfield MO, US
Patrick James Lennon - Webster Groves MO, US

Assignee:

Pharmacia & Upjohn Company - Peapack NJ

International Classification:

C07D295/096
C07C215/54
A61K031/40
A61K031/14
A61P011/06

US Classification:

51421201, 514317, 514428, 514546, 514547, 514643, 540609, 546240, 548575, 560140, 564283

Abstract:

Novel quaternary ammonium compounds of the formula and any stereoisomers thereof, wherein R, Rand Rindependently represent C-Calkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R, Rand Rmay form a ring together with the quaternary ammonium nitrogen; Rrepresents —H, —CH, or —CO—R, wherein Rrepresents —(C-Calkyl), —(C-Calkoxy), or —NRR, wherein Rand Rindependently represent —H or —(C-Calkyl); R, Rand Rindependently represent —H, —OCH, —OH, —CONH, —SONH, —F, —Cl, —Br, —I, —CF, or —(C-Calkyl), optionally substituted with one or two —OH, —(C-Calkoxy), —COOH, or —CO—O—(C-Calkyl); and X represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.

US Patent:

6956048, Oct 18, 2005

Filed:

Mar 22, 2000

Appl. No.:

09/532396

Inventors:

Youmin Wang - Brookfield WI, US
Walter Morozowich - Kalamazoo MI, US

Assignee:

Pharmacia & UpJohn Company - Kalamazoo MI

International Classification:

A61K031/44
A01N043/40

US Classification:

514336, 424450

Abstract:

The present invention provides an emulsion formulation with high oral bioavailability containing lecithin as an emulsifier and solubilizing agent to achieve a high loading of the pyranone compound of formula I.

US Patent:

7005449, Feb 28, 2006

Filed:

Apr 23, 2002

Appl. No.:

10/127875

Inventors:

Michael Hawley - Kalamazoo MI, US
Satish Kumar Singh - Portage MI, US
Walter Morozowich - Kalamazoo MI, US
Mark P. Warchol - Kalamazoo MI, US

Assignee:

Pharmacia & Upjohn Company - Kalamazoo MI

International Classification:

A61K 31/205
C07C 215/56
C07C 209/00

US Classification:

514555, 562490, 564395, 564413

Abstract:

The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are pharmaceutically acceptable salts of tolterodine or hydroxytolterodine, wherein the salt is of an acid selected from the group consisting of aliphatic mono- and dicarboxylic acids comprising from 7 to 24 carbon atoms, alkanedisulfonic acids comprising from 2 to 4 carbon atoms, naphthoic acid derivatives comprising from 11 to 27 carbon atoms, maleic acid and fumaric acid.