Winston K Wu

US Patent:

8145434, Mar 27, 2012

Filed:

Apr 10, 2009

Appl. No.:

12/422125

Inventors:

Josh Yehoshua Shachar - Santa Monica CA, US
Winston H. Wu - Alhambra CA, US
Leslie Farkas - Ojai CA, US
Thomas Chen - La Canada CA, US

Assignee:

Pharmaco-Kinesis Corporation - Inglewood CA

International Classification:

G06F 11/00

US Classification:

702 19

Abstract:

A novel architecture solid-state biosensor for label-free detection of vascular endothelial growth factor (VEGF) hybridization is presented. The new device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. The detection mechanism is based on an electrochemical binding of circulating VEGF to an immobilized VEGF aptamer; whereby binding of these two compounds modulates the threshold voltage of a novel circuit, changing the impedance (capacitance) of the circuit. This novel circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the VEGF molecules and the aptamer. An apparatus forming a fluid cell is configured so as to enable the flow for delivering VEGF samples onto the active surface of the chip. The device has an array of parallel capacitors which act as an integrated, individual counter-electrode, computational apparatus which employs the sensory output over the time domain so as to enable detection, reporting and formation of a homeostatic loop for VEGF measurements.

US Patent:

8571805, Oct 29, 2013

Filed:

Jun 22, 2010

Appl. No.:

12/820830

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Winston Wu - Alhambra CA, US
Thomas Chen - La Canada CA, US
Brett Jordan - Los Angeles CA, US
Kyle Zimmerman - Los Angeles CA, US
Herwin Chan - Los Angeles CA, US
Paladin Luboff - Santa Monica CA, US

Assignee:

Pharmaco-Kinesis Corporation - Century City CA

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.

US Patent:

20100160737, Jun 24, 2010

Filed:

Dec 23, 2008

Appl. No.:

12/343436

Inventors:

Josh Shachar - Santa Monica CA, US
Thomas Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Winston Wu - Alhambra CA, US
Kyle Zimmerman - Los Angeles CA, US
Moran Cerf - Los Angeles CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Laszlo Farkas - Ojai CA, US

International Classification:

A61B 1/32
A61B 5/00

US Classification:

600202

Abstract:

Described is a surgical system for monitoring a patient's condition during surgery. One aspect is a non-contact EEG sensor. The non-contact EEG sensor can be used to predict the onset of physiological disorders. Another aspect includes the use of a plurality of pressure sensors to determine the pressure applied by retractors on the patient, including the brain and other organs.

US Patent:

20110092948, Apr 21, 2011

Filed:

Oct 19, 2009

Appl. No.:

12/581785

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas C. Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Brett Jordan - Los Angeles CA, US
Kyle Zimmerman - Los Angeles CA, US
Herwin Chan - Los Angeles CA, US
Winston Wu - Alhambra CA, US

Assignee:

PHARMACO-KINESIS CORPORATION - Inglewood CA

International Classification:

A61M 1/00
A61M 37/00

US Classification:

604500, 604131, 604 67

Abstract:

The present disclosure describes a remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.

US Patent:

20110162979, Jul 7, 2011

Filed:

Apr 21, 2010

Appl. No.:

12/764828

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Winston Wu - Alhambra CA, US
Thomas Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Brett Jordan - Los Angeles CA, US
Paladin Luboff - Santa Monica CA, US
Herwin Chan - Los Angeles CA, US
Kyle Nichdas Zimmerman - Los Angeles CA, US

Assignee:

PHARMACO-KINESIS CORPORATION - Inglewood CA

International Classification:

G01N 27/26
G01N 33/50

US Classification:

2057775, 20440301

Abstract:

An aptamer-based solid-state electrochemical biosensor for label-free detection of serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

US Patent:

20110166033, Jul 7, 2011

Filed:

Jan 7, 2010

Appl. No.:

12/684025

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Winston Wu - Alhambra CA, US
Thomas Chen - La Canada CA, US
Leslie Farkas - Ojai CA, US
Brett Jordan - Los Angeles CA, US
Paladin Luboff - Santa Monica CA, US
Herwin Chan - Los Angeles CA, US
Kyle Zimmerman - Los Angeles CA, US

Assignee:

PHARMACO-KINESIS CORPORATION - Inglewood CA

International Classification:

C40B 30/04
C40B 60/12

US Classification:

506 9, 506 39

Abstract:

An aptamer-based solid-state electrochemical biosensor for label-free detection of serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

US Patent:

20110295159, Dec 1, 2011

Filed:

May 25, 2010

Appl. No.:

12/787286

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Thomas Chen - La Canada CA, US
Winston Wu - Alhambra CA, US
Brett Jordan - Los Angeles CA, US
Herwin Chan - Los Angeles CA, US
Paladin Luboff - Santa Monica CA, US
Kyle Zimmerman - Los Angeles CA, US

Assignee:

PHARMACO-KINESIS CORPORATION - Inglewood CA

International Classification:

A61B 5/103
A61F 2/44

US Classification:

600594, 623 1711

Abstract:

A vertebral processor designed to collect and interpret data from multiple surgically implanted accelerometers. Each accelerometer is surgically implanted into a vertebra of a patient utilizing a bone screw. Additional accelerometers are implanted in adjacent vertebrae. The data from the accelerometers is compared by an algorithm to determine the relative movement of the accelerometers implanted in adjacent vertebrae. Data is generated via the algorithm and compared against the expected behavior of the surgically implanted accelerometers as if they were connected to a rigid body, thus determining the level of success of a spinal fusion procedure for those adjacent segments. The apparatus may be utilized with or without spinal stabilization hardware, and with or without fusion cages or artificial discs. The vertebral processor is supplemented by an external system worn by the patient, which provides for an inductive charging power source and for data transfer.

US Patent:

20110301497, Dec 8, 2011

Filed:

Dec 8, 2010

Appl. No.:

12/963502

Inventors:

Yehoshua Shachar - Santa Monica CA, US
Laszlo Farkas - Ojai CA, US
Bruce Marx - Ojai CA, US
David Johnson - West Hollywood CA, US
Shawn Hakim - Northridge CA, US
Winston Wu - Alhambra CA, US

Assignee:

MAGNETECS CORPORATION - Inglewood CA

International Classification:

A61B 10/04
A61B 1/04
A61B 1/00

US Classification:

600567, 600114, 600104, 600109

Abstract:

A guided medical propulsion capsule driven by strong electro-magnetic interaction between an external AC/DC magnetic gradient-lobe generator and a set of uniquely magnetized ferrous-conductive elements contained within the capsule. The capsule is navigated through the lumens and cavities of the human body wirelessly and without any physical contact for medical diagnostic, drug delivery, or other procedures with the magnetically guiding field generator external to the human body. The capsule is equipped with at least two sets of magnetic rings, disks and/or plates each possessing anisotropic magnetic properties. The external magnetic gradient fields provide the gradient forces and rotational torques on the internal conductive and magnetic elements needed to make the capsule move, tilt, and rotate in the body lumens and cavities according to the commands of an operator.