Jul 1988 to Apr 1990 Electrical EngineerBejing Radar Research Institute, Bejing China
Oct 1982 to Jun 1988 RF Design Engineer
Education:
City University of New York New York, NY Feb 1995 to Jun 1996 Master in Electrical EngineeringUniversity of Wuppertal Jul 1990 to Mar 1994 Electrical Engineering DepartmentNational Defense University of Science and Technology Sep 1978 to Aug 1982 Bachelor in Microwaves Technology
- Madison NJ, US Yuanzheng Zhang - Somerset NJ, US Jason Erskine - Omaha NE, US Ian Tarpey - St. Ives, US
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28 A61K 39/00
Abstract:
The present invention discloses antibodies including caninized antibodies against canine PD-L1 with specific properties. The present invention further relates to epitopes of canine PD-L1 that bind to these antibodies, as well as to anti-canine PD-L1 antibodies that bind these epitopes. The invention further discloses the use of the caninized anti-canine PD-LI antibodies of the present invention in the treatment of cancer in dogs.
- Madison NJ, US Yuanzheng Zhang - Somerset NJ, US Ian Tarpey - St. Ives, GB
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28
Abstract:
The present invention provides caninized murine antibodies against canine CTLA-4 that have specific sequences and a high binding affinity for canine CTLA-4. The present invention further provides epitopes of canine CTLA-4 for caninized murine antibodies against canine CTLA-4.5 The invention also relates to use of these antibodies in the treatment of cancer in canines and other companion animals.
- Madison NJ, US Yuanzheng Zhang - Somerset NJ, US Ian Tarpey - St. Ives, GB
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28
Abstract:
The present invention provides caninized anti-human CTLA-4 antibodies that have specific sequences and a high binding affinity for canine CTLA-4. The invention also relates to use of these antibodies in the treatment of cancer in canines and other companion animals.
- Madison NJ, US Yuanzheng Zhang - Edison NJ, US Ian Tarpey - St. Ives, GB
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28 A61K 39/00 A61P 37/04 A61K 39/395
Abstract:
The present invention discloses caninized antibodies with specific properties. The present invention also discloses caninized murine antibodies against canine PD-1 that have a high binding affinity for canine PD-1. The invention further discloses the use of the caninized antibodies of the present invention in the treatment of cancer in dogs.
- Madison NJ, US Yuanzheng Zhang - Somerset NJ, US
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28
Abstract:
The present invention provides antibodies to canine IL-4 receptor alpha that have a highbinding affinity for canine IL-4 receptor alpha, and that can block the binding of canine IL-4 and/or IL-13 to canine IL-4 receptor alpha. The present invention further relates to epitopes of canine IL-4 receptor alpha that bind to the antibodies to canine IL-4 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
- Madison NJ, US Yuanzheng Zhang - Somerset NJ, US
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28 A61P 17/00 C12N 15/85 C12N 5/071
Abstract:
The present invention provides antibodies to canine IL-4 receptor alpha that have a high binding affinity for canine IL-4 receptor alpha, and that can block the binding of canine IL-4 and/or IL-13 to canine IL-4 receptor alpha. The present invention further relates to epitopes of IL-4 receptor alpha that bind to the antibodies to canine IL-4 receptor alpha. The present invention further provides the use of the antibodies for the treatment of atopic dermatitis in dogs.
- Madison NJ, US Yuanzheng Zhang - Somerset NJ, US
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28
Abstract:
The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor α. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.
- Madison NJ, US Yuanzheng Zhang - Edison NJ, US Jason Erskine - Omaha NE, US Ian Tarpey - St. Ives, GB
Assignee:
Intervet Inc. - Madison NJ
International Classification:
C07K 16/28 A61K 39/00 A61P 37/04 A61K 39/395
Abstract:
The present invention discloses antibodies to canine PD-1 that have specific sequences and a high binding affinity for canine PD-1. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.