Aaron Liu

US Patent:

20200218050, Jul 9, 2020

Filed:

Jan 14, 2019

Appl. No.:

16/626113

Inventors:

- San Diego CA, US
Danilo Condello - San Francisco CA, US
Shaoping Lu - Palo Alto CA, US
Simon Prince - Carlsbad CA, US
Merek C. Siu - Alameda CA, US
Stanley S. Hong - Palo Alto CA, US
Aaron Liu - Riverside CA, US

International Classification:

G02B 21/06
G01N 21/64
G02B 21/18

Abstract:

The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

US Patent:

20200192071, Jun 18, 2020

Filed:

Jan 14, 2019

Appl. No.:

16/621111

Inventors:

- San Diego CA, US
- Cambridge, GB
Shaoping Lu - Palo Alto CA, US
Simon Prince - Carlsbad CA, US
Merek C. Siu - Alameda CA, US
Stanley S. Hong - Palo Alto CA, US
Aaron Liu - Riverside CA, US
Gary Mark Skinner - Kedington, GB
Geraint Wyn Evans - Cambridge, GB

International Classification:

G02B 21/06
G02B 21/26
G02B 27/42
G02B 27/10
G02B 5/18
G02B 21/00
G02B 21/36
G02B 27/28
G02B 21/16
H04N 5/235

Abstract:

The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

US Patent:

20190302024, Oct 3, 2019

Filed:

Mar 12, 2019

Appl. No.:

16/351193

Inventors:

- San Diego CA, US
Stanley S. Hong - Palo Alto CA, US
Frederick Erie - Carlsbad CA, US
Alex Nemiroski - San Diego CA, US
M. Shane Bowen - Encinitas CA, US
Danilo Condello - San Francisco CA, US
Dietrich Dehlinger - San Francisco CA, US
Marco A. Krumbuegel - San Ramon CA, US
Anthony Lam - Fremont CA, US
Aaron Liu - Irvine CA, US
Bojan Obradovic - Carlsbad CA, US
Mark Pratt - Belmont CA, US

International Classification:

G01N 21/64

Abstract:

A system includes: an objective lens; a first light source to feed first illuminating light through the objective lens and into a flowcell (e.g., with a relatively thin film waveguide) to be installed in the system, the first illuminating light to be fed using a first grating on the flowcell; and a first image sensor to capture imaging light using the objective lens, wherein the first grating is positioned outside a field of view of the first image sensor. Dual-surface imaging can be performed. Flowcells with multiple swaths bounded by gratings can be used. An auto-alignment process can be performed.