Adrian M Wilson

US Patent:

6555064, Apr 29, 2003

Filed:

Mar 16, 2001

Appl. No.:

09/811216

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3386

US Classification:

422 681, 422 73, 436 10, 436 69

Abstract:

An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets using a plunger sensor technique, the apparatus comprising a test cell, and wherein the test cell comprises an anticoagulant, a contact activator, and a predetermined amount of a platelet inactivating agent.

US Patent:

6555066, Apr 29, 2003

Filed:

Mar 16, 2001

Appl. No.:

09/810747

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3316

US Classification:

422 73, 436 10, 436 69, 435 4, 435 13

Abstract:

An apparatus for performing a platelet inhibition test on a sample of blood is provided, comprising a plurality of test cells, the cells being adapted for receiving an aliquot portion of the sample, wherein each of the cells comprises an anticoagulant and a clotting activator, and wherein at least one of the cells further comprises a platelet inactivating agent, wherein a clotting time is determined for each of the aliquot portions, and wherein a relative clotting time for each of the aliquot portions comprising the platelet inhibitor is determined as compared to a reference clotting time for a cell containing no platelet inhibitor, wherein the relative clotting times for the cells are determinative of the platelet inhibition of the sample.

US Patent:

6555381, Apr 29, 2003

Filed:

Mar 16, 2001

Appl. No.:

09/810740

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3386

US Classification:

436 69, 436 10, 422 73, 435 4, 435 13

Abstract:

A method of determining a contact activator for platelet activation and/or clotting activation is provided, comprising placing a predetermined amount of an anticoagulant in each cell of a multicell test cartridge, placing a predetermined amount of a platelet inactivating agent in each cell, and placing a measured amount of contact activator in each cell, the amount of contact activator in each cell differing from the amount in each other cell. An aliquot of a blood sample is added to each cell, and the blood sample aliquot, clotting reagent and platelet inactivating agent are mixed. Each cell sample is allowed to clot, and the clotting time for each cell is measured. The relative clotting times are used to determine the platelet activation and/or clotting activation effect of the clotting activator.

US Patent:

6761856, Jul 13, 2004

Filed:

Apr 9, 2003

Appl. No.:

10/410003

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3386

US Classification:

422 73, 422 681, 436 10, 436 69

Abstract:

An apparatus is provided for performing an activated clotting time test on a sample of blood containing platelets, the apparatus comprising a plurality of test cells, said cells being adapted for receiving an aliquot portion of said sample, wherein each of said cells comprises an anticoagulant and a platelet inactivating agent, and wherein at least one of said cells further comprises a clotting activator, wherein a clotting time is determined for each of said aliquot portions, and wherein a relative clotting time for each of said aliquot portions comprising the clotting activator is determined as compared to a reference clotting time for said at least one cell containing no clotting activator, wherein said relative clotting times in said cells are determinative of the clotting activation of said clotting activator.

US Patent:

6955920, Oct 18, 2005

Filed:

Jun 11, 1999

Appl. No.:

09/330544

Inventors:

Robert F. Baugh - Parker CO, US
Carole G. Lane - Greenwood Village CO, US
Adrian C. Wilson - Denver CO, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N033/86

US Classification:

436 69, 422 73, 73 5401

Abstract:

Apparatus and method for evaluating platelet functionality of a blood sample. A cartridge includes a plurality of test cells. Each cell receives an aliquot part of a blood sample. A measured amount of clotting reagent is provided in each cell. A measured amount of platelet activation reagent is provided in each cell, the amount of such reagent in each cell differing from the amount of such reagent in each other cell. The relative clotting times of the aliquot samples in the cells are determinative of the platelet functionality of the blood sample.

US Patent:

60109114, Jan 4, 2000

Filed:

Apr 30, 1997

Appl. No.:

8/847152

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3316

US Classification:

436 69

Abstract:

An apparatus and method for performing activated clotting time tests, including their use for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells comprises a heparin-inactivating agent, an anticoagulant agent, and a clotting reagent. At least one of the test cells further comprises a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method comprises the steps of combining a heparin-inactivating agent, an anticoagulant agent, a clotting reagent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by agitating the test mixture, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.

US Patent:

59253193, Jul 20, 1999

Filed:

Apr 30, 1996

Appl. No.:

8/640275

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3102
G01N 3348

US Classification:

422 73

Abstract:

Apparatus and method for evaluating platelet functionality of a blood sample. A cartridge includes a plurality of test cells. Each cell receives an aliquot part of a blood sample. A measured amount of clotting reagent is provided in each cell. A measured amount of platelet activation reagent is provided in each cell, the amount of such reagent in each cell differing from the amount of such reagent in each other cell. The relative clotting times of the aliquot samples in the cells are determinative of the platelet functionality of the blood sample.

US Patent:

62216724, Apr 24, 2001

Filed:

Jan 4, 1999

Appl. No.:

9/225051

Inventors:

Robert F. Baugh - Parker CO
Carole G. Lane - Greenwood Village CO
Adrian C. Wilson - Denver CO

Assignee:

Medtronic, Inc.

International Classification:

G01N 3386
C12Q 156

US Classification:

436 69

Abstract:

A method of determining a dose response for a platelet inhibitor. The method includes the steps of placing a predetermined amount of heparin in each cell of a multicell test cartridge, placing an optimized amount of a clotting activator in each cell, and placing a measured amount of platelet inhibitor in each cell, the amount of inhibitor in each cell differing from the amount in each other cell. An aliquot of a blood sample is added to each cell, and the blood sample aliquot, clotting reagent and platelet inhibitor are mixed. Each cell sample is allowed to clot, and the clotting time for each cell is measured. The relative clotting times are used to calculate and determine the platelet inhibition effect of the platelet inhibitor.