Amy Lu

US Patent:

6943162, Sep 13, 2005

Filed:

Jan 23, 2002

Appl. No.:

10/466847

Inventors:

Ronnie Lee Hale - Woodside CA, US
Brad Richard Henke - Durham NC, US
Amy Tsai Lu - Los Altos CA, US
Paul Kenneth Spearing - Durham NC, US
Philip Stewart Turnbull - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D403/02
A61K031/53
A61P005/30
A61P035/00

US Classification:

514241, 544198, 544207, 544209

Abstract:

Triazine derivatives of formula (I), which exhibit pharmacological activity at estrogen receptors alpha (ER alpha) and beta (ER beta) are described herein. The described invention also includes compositions and medicaments containing the triazine derivatives as well as processes for the preparation and use of such compounds, compositions and medicaments.

US Patent:

7090830, Aug 15, 2006

Filed:

Nov 20, 2003

Appl. No.:

10/718982

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Palo Alto CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424489, 424499, 514958, 12820014, 12820024, 12820315

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1–3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0. 05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

7550133, Jun 23, 2009

Filed:

Nov 20, 2003

Appl. No.:

10/719899

Inventors:

Ron L. Hale - Woodside CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424489, 424434, 424499, 514958, 12820014, 12820024, 12820315

Abstract:

Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described.

US Patent:

7585493, Sep 8, 2009

Filed:

Aug 4, 2003

Appl. No.:

10/633877

Inventors:

Ron L. Hale - Woodside CA, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424434, 424489, 424499, 514958, 12820014, 12820015, 12820024

Abstract:

An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0. 05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.

US Patent:

7645442, Jan 12, 2010

Filed:

Aug 4, 2003

Appl. No.:

10/633876

Inventors:

Ron L. Hale - Woodside CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Reynaldo J. Quintana - Redwood City CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Dennis W. Solas - San Francisco CA, US
Soonho Song - Palo Alto CA, US
Curtis Tom - San Mateo CA, US
Martin J. Wensley - San Francisco CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 9/12
A61K 9/14
A61M 15/00

US Classification:

424 45, 424 46, 424434, 424489, 424499, 12820014, 12820024, 12820315, 514958

Abstract:

A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 C. , and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.

US Patent:

8235037, Aug 7, 2012

Filed:

May 8, 2008

Appl. No.:

12/117737

Inventors:

Ron L. Hale - Woodside CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Martin J. Wensley - Los Gatos CA, US
Jeffrey A. McKinney - Lafayette CA, US
Alejandro C. Zaffaroni - Atherton CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61M 15/00
A61K 9/12
A61K 9/14
H05B 3/00

US Classification:

12820014, 12820016, 12820021, 12820024, 12820315, 12820415, 424 45, 424 46, 424434, 424489

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0. 05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

20040101481, May 27, 2004

Filed:

Nov 20, 2003

Appl. No.:

10/719763

Inventors:

Ron Hale - Woodside CA, US
Peter Lloyd - Walnut Creek CA, US
Amy Lu - Los Altos CA, US
Patrik Munzar - Belmont CA, US
Joshua Rabinowitz - Mountain View CA, US
Roman Skowronski - Palo Alto CA, US

Assignee:

Alexza Molecular Delivery Corporation - Palo Alto CA

International Classification:

A61L009/04

US Classification:

424/045000

Abstract:

Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.

US Patent:

20050037506, Feb 17, 2005

Filed:

Aug 4, 2004

Appl. No.:

10/912462

Inventors:

Ron Hale - Woodside CA, US
Amy Lu - Los Altos CA, US
Daniel Myers - Mountain View CA, US
Joshua Rabinowitz - Princeton NJ, US

Assignee:

Alexza Molecular Delivery Corporation - Palo Alto CA

International Classification:

G01N001/18

US Classification:

436157000

Abstract:

Methods for determining the film thickness of a compound composition needed to provide a selected purity and yield of a condensation aerosol via vaporization of the compound composition have applications in aerosol delivery technology, in pulmonary drug delivery, and in other therapeutic treatment regimes. The methods for determining such film thickness, for use in a device having a film of drug composition to be aerosolized, include generating purities and yields of a drug composition by vaporizing films of the drug composition from substrates at two or more temperatures in the range of 150 C. to 500 C. and two or more film thickness in the range of 0.05 to 50 microns, determining from these yields and purities if a thickness and temperature exist where the aerosol has at least 90% purity and at least 50% yield, and repeated such measurements until the selected purity and yield requirement are met.