Amy Minyi Lu

US Patent:

20140060525, Mar 6, 2014

Filed:

Nov 13, 2013

Appl. No.:

14/078679

Inventors:

Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Martin J. Wensley - Los Gatos CA, US
Jeffrey A. McKinney - Lafayette CA, US
Alejandro C. Zaffaroni - Atherton CA, US

Assignee:

Alexza Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61M 11/04

US Classification:

12820014

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

20190336437, Nov 7, 2019

Filed:

Jul 12, 2019

Appl. No.:

16/510846

Inventors:

- Mountain View CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Martin J. Wensley - Los Gatos CA, US
Jeffrey A. McKinney - Lafayette CA, US
Alejandro C. Zaffaroni - Atherton CA, US

International Classification:

A61K 9/00
A61M 11/00
A61K 31/5517
A61K 9/12
A61M 11/04
A61M 15/00
A61K 31/553
A61K 31/5415
A61K 31/519
A61K 31/4468

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

20160374937, Dec 29, 2016

Filed:

Sep 12, 2016

Appl. No.:

15/262954

Inventors:

- Mountain View CA, US
Craig C. Hodges - Walnut Creek CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Daniel J. Myers - Mountain View CA, US
Joshua D. Rabinowitz - Princeton NJ, US
Martin J. Wensley - Los Gatos CA, US
Jeffrey A. McKinney - Lafayette CA, US
Alejandro C. Zaffaroni - Atherton CA, US

International Classification:

A61K 9/00
A61K 9/12
A61K 31/553
A61M 11/04
A61M 11/00

Abstract:

The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

US Patent:

20150250800, Sep 10, 2015

Filed:

May 26, 2015

Appl. No.:

14/721896

Inventors:

- Mountain View CA, US
Peter M. Lloyd - Walnut Creek CA, US
Amy T. Lu - Los Altos CA, US
Patrik Munzar - Livermore CA, US
Joshua Rabinowitz - Princeton NJ, US
Roman Skowronski - Palo Alto CA, US

International Classification:

A61K 31/553
A61K 31/496
A61K 31/4439
A61K 9/00
A61K 31/445

Abstract:

Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.