Anil H Nair

US Patent:

7164021, Jan 16, 2007

Filed:

Sep 18, 2003

Appl. No.:

10/665377

Inventors:

William J. Welsh - Princeton NJ, US
Seong Jae Yu - Pennington NJ, US
Anil Nair - Oro Valley AZ, US

Assignee:

The Curators of The University of Missouri - Columbia MO

International Classification:

C07D 471/02
C07D 471/08

US Classification:

546 44, 546 45, 546 46

Abstract:

Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known μ-opioid receptor selectors as analgesics.

US Patent:

7294720, Nov 13, 2007

Filed:

Jan 23, 2006

Appl. No.:

11/337366

Inventors:

William J. Welsh - Princeton NJ, US
Seong Jae Yu - Pennington NJ, US
Anil Nair - Oro Valley AZ, US

Assignee:

The Curators of the University of Missouri - Columbia MO

International Classification:

C07D 249/08
A61K 31/4196

US Classification:

5482648, 5482622, 514383

Abstract:

The invention provides compounds of formula I:.

US Patent:

7776898, Aug 17, 2010

Filed:

Sep 18, 2007

Appl. No.:

11/857193

Inventors:

William J. Welsh - Princeton NJ, US
Seong Jae Yu - Pennington NJ, US
Anil Nair - Oro Valley AZ, US

Assignee:

The Curators of the University of Missouri - Columbia MO

International Classification:

A61K 31/4196
C07D 249/08

US Classification:

514383, 5482622, 5482648

Abstract:

The invention provides compounds of formula I:.

US Patent:

20030225072, Dec 4, 2003

Filed:

Feb 7, 2003

Appl. No.:

10/360602

Inventors:

William Welsh - Princeton NJ, US
Seong Yu - Pennington NJ, US
Anil Nair - Tuscon AZ, US

International Classification:

A61K031/541
A61K031/5377
A61K031/496
A61K031/454
A61K031/4196
C07D417/02
C07D413/02
C 07D 4 3/02

US Classification:

514/227800, 514/236200, 514/254050, 514/326000, 514/383000, 544/060000, 544/133000, 544/366000, 546/210000, 548/264800

Abstract:

The invention provides compounds of formula I: wherein Rto Rand n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

US Patent:

20070105884, May 10, 2007

Filed:

Aug 22, 2006

Appl. No.:

11/507955

Inventors:

William Welsh - Princeton NJ, US
Seong Yu - Pennington NJ, US
Anil Nair - Oro Valley AZ, US

International Classification:

A61K 31/485
C07D 489/02

US Classification:

514279000, 546034000

Abstract:

Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known μ-opioid receptor selectors as analgesics.