Aoife M Brennan

US Patent:

20130171142, Jul 4, 2013

Filed:

Oct 20, 2010

Appl. No.:

13/502625

Inventors:

Aoife Brennan - Dover MA, US
Charlotte Mckee - Newton MA, US
Lou Vaickus - Hingham MA, US
Douglas Ringler - Boston MA, US

International Classification:

A61K 39/395

US Classification:

4241351, 4241731, 4241331

Abstract:

Provided herein are methods of administering anti-CD3 antibodies or antigen binding fragments to a human for decreasing weight gain or increasing weight loss. In certain embodiments, the human exhibits a body mass index (BMI) or greater than or equal to about 27. In certain embodiments, the anti-CD3 antibody or antigen binding fragment does not bind or has reduced binding to at least one class of Fc (gamma) receptor.

US Patent:

20130095121, Apr 18, 2013

Filed:

Jun 24, 2011

Appl. No.:

13/704692

Inventors:

Aoife Brennan - Dover MA, US
Charlotte McKee - Newton MA, US
Lou Vaickus - Hingham MA, US

International Classification:

A61K 39/395

US Classification:

4241731

Abstract:

Provided herein are methods of treating patients with immune-related diseases (e.g., diabetes) with immunotherapy.