Bogdan A Czerniak

US Patent:

20030165895, Sep 4, 2003

Filed:

Jun 11, 2002

Appl. No.:

10/167241

Inventors:

Bogdan Czerniak - Houston TX, US
Dennis Johnston - Houston TX, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Disclosed are methods, compositions and apparatus useful in the detection, monitoring and treatment of the progression of neoplasia and preneoplastic conditions with special emphasis on the chromosomal changes related to the development and progression of urothelial neoplasia. Chromosomal changes, including LOH, at the disclosed loci demonstrate a statistically significant relation to the progression of disease state in urothelial neoplasia.

US Patent:

20100285486, Nov 11, 2010

Filed:

Dec 12, 2008

Appl. No.:

12/811384

Inventors:

H. Barton Grossman - Bellaire TX, US
Bogdan Czerniak - Houston TX, US
Sen Subrata - Sugar Land TX, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

We disclose a method of detecting bladder cancer in a patient, comprising isolating bladder cells from the patient's urine; hybridizing the bladder cells with a labelled DNA probe, wherein the probe recognizes at least a portion of the aurora kinase A gene, to yield a sample of bladder cells hybridized with the labeled DNA probe; and counting the number of bladder cells in the sample, the number of copies of the aurora kinase A gene in each bladder cell in the sample, and the number of bladder cells in the sample having at least a first threshold number of copies of the aurora kinase A gene.

US Patent:

20120230952, Sep 13, 2012

Filed:

Mar 12, 2012

Appl. No.:

13/417642

Inventors:

Woonbok Chung - Haverford PA, US
Bogdan A. Czerniak - Houston TX, US
Jean-Pierre Issa - Philadelphia PA, US

International Classification:

C12Q 1/68
A61K 33/24
C40B 30/04
A61K 38/21
G01N 21/64
C40B 40/06

US Classification:

424 854, 435 611, 506 16, 506 9, 424649

Abstract:

Provided are methods for detecting bladder cancer in a subject. In some aspects, methylation of one or more of MYO3A, CA10, NKX6-2, SOX11, DBC1, NPTX2, and/or A2BP1 in DNA sediment from a urine sample may be evaluated to detect the presence or absence of a bladder cancer in a human patient.

US Patent:

20150315661, Nov 5, 2015

Filed:

Jul 21, 2015

Appl. No.:

14/805204

Inventors:

- Austin TX, US
Bogdan Czerniak - Houston TX, US
Sen Subrata - Sugar Land TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q 1/68

Abstract:

We disclose a method of detecting bladder cancer in a patient, comprising isolating bladder cells from the patient's urine; hybridizing the bladder cells with a labelled DNA probe, wherein the probe recognizes at least a portion of the aurora kinase A gene, to yield a sample of bladder cells hybridized with the labeled DNA probe: and counting the number of bladder cells in the sample, the number of copies of the aurora kinase A gene in each bladder cell in the sample, and the number of bladder cells in the sample having at least a first threshold number of copies of the aurora kinase A gene.

US Patent:

20150292030, Oct 15, 2015

Filed:

Nov 27, 2013

Appl. No.:

14/647587

Inventors:

- Austin, TX, US
Colin Dinney - Houston TX, US
Bogdan Czerniak - Houston TX, US
Keith Baggerly - Houston TX, US
Mai Tran - Houston TX, US
Woonyoung Choi - Bellaire TX, US
Neema Navai - Houston TX, US
Liana Adam - Pearland TX, US
Arlene Siefker-Radtke - Pearland TX, US
Matthew Wszolek - Boston MA, US

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

C12Q 1/68
A61K 33/24
A61K 31/185
C01B 21/092
A61K 31/506
A61K 31/404
A61K 31/53
A61K 31/553
A61K 31/496

Abstract:

The present application discloses a method of diagnostic testing of primary tumors, circulating tumor cells, serum, and urine to detect high-risk bladder cancers. These results have immediate implications for prognostication and the clinical management of muscle-invasive bladder cancer.