Brian Liu

US Patent:

8476026, Jul 2, 2013

Filed:

Mar 20, 2009

Appl. No.:

12/935210

Inventors:

Ng Alex - Newton MA, US
Brian Liu - Somerville MA, US

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The invention is directed to assays for biomarkers associated with ovarian cancer that can be used diagnostically. It includes glass or plastic plates or slides on which the biomarkers have been immobilized and kits containing these plates or slides.

US Patent:

20080081339, Apr 3, 2008

Filed:

Oct 1, 2007

Appl. No.:

11/905474

Inventors:

Brian Liu - Somerville MA, US
Joshua Ehrlich - Duluth GA, US
Weiliang Qiu - Brookline MA, US

Assignee:

The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435006000, 435007920

Abstract:

The invention is directed to tumor associated markers (TAMs) that can be used diagnostically, especially in the diagnosis of prostate cancer and other markers (BPHMs) that can be used in the diagnosis of benign prostate hyperplasia. It also includes glass or plastic plates or slides on which the TAMs or BPHMs have been immobilized.

US Patent:

20090075305, Mar 19, 2009

Filed:

May 1, 2006

Appl. No.:

11/919703

Inventors:

Brian Liu - Somerville MA, US
Shuzhen Qin - West Roxbury MA, US
Joshua Ehrlich - Duluth GA, US

Assignee:

The Brigham and Womern's Hospital, Inc. - Boston MA

International Classification:

G01N 33/53

US Classification:

435 792, 435 71

Abstract:

The invention is directed to a microarray assay procedure that can be used for profiling the antibodies present in serum, plasma or blood. The assay may be used to identify antibodies and antigens that are characteristic of particular diseases or conditions. In addition, the invention includes specific antigens that are associated with prostate cancer, progressive benign prostate hyperplasia (BPH) and ovarian cancer.

US Patent:

20120295814, Nov 22, 2012

Filed:

Jan 7, 2011

Appl. No.:

13/520665

Inventors:

Daniel Cramer - Chestnut Hill MA, US
Brian Liu - Somerville MA, US
Dennis O'Rourke - West Townsend MA, US

Assignee:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

G01N 33/574
G01N 33/577
C40B 30/04

US Classification:

506 9, 436501

Abstract:

The invention is directed to assays of CA-125 immune complexes that can be used diagnostically. It also includes glass or plastic plates or slides on which the monoclonal antibodies against CA-125 have been immobilized and kits containing these plates or slides.

US Patent:

20140066325, Mar 6, 2014

Filed:

Mar 15, 2012

Appl. No.:

14/005551

Inventors:

Brian Liu - Somerville MA, US
Robert Caiazzo - Essex CT, US
David Ure - Wellesley MA, US
James Nelson - Raleigh NC, US

Assignee:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

G01N 33/574

US Classification:

506 9, 436501, 435 792, 506 18

Abstract:

The invention is directed to tumor associated markers (TAMs) and autoantibody biomarkers that can be used diagnostically. It also includes methods for detection of the markers and compositions that can be used in carrying out assays

US Patent:

6374032, Apr 16, 2002

Filed:

Apr 22, 1999

Appl. No.:

09/299553

Inventors:

Hongwei Mao - San Jose CA
Jian Chen - San Jose CA
Brian Liu - San Jose CA

Assignee:

JDS Uniphase Corporation - San Jose CA

International Classification:

G02B 600

US Classification:

385140, 385 25, 359236

Abstract:

A variable optical attenuator is described. A special profile blocker is rotated across a large angel (e. g. , 180Â to 360Â) to provide a variable amount of attenuation. In one embodiment, the special profile blocker is an eccentrically driven wheel. The special profile blocker is driven by a stepper motor via a gear assembly. In one embodiment, the variable optical attenuator includes a beam splitter for the input and/or the output signal for monitoring of signal strength and/or feedback control of the attenuator.