Carl Brooks

US Patent:

20210299113, Sep 30, 2021

Filed:

Sep 20, 2017

Appl. No.:

16/334400

Inventors:

- Brentford, Middlesex, GB
Carl A. BROOKS - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Peng LI - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
Matthew Robert SENDER - Collegeville PA, US
Lamont Roscoe TERRELL - Collegeville PA, US
David J. BEHM - Collegeville PA, US

International Classification:

A61K 31/4439
A61K 45/06
C07D 401/12
C07D 207/48
A61K 31/40
C07D 417/12
A61K 31/427
C07D 403/12
A61K 31/506
C07D 498/10
A61K 31/5386

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

US Patent:

20200308160, Oct 1, 2020

Filed:

May 18, 2017

Appl. No.:

16/302118

Inventors:

- Brentford, Middlesex, GB
Carl A. BROOKS - Collegeville PA, US
Guosen YE - Collegeville PA, US

International Classification:

C07D 413/14
A61K 9/20
A61K 9/00

Abstract:

The present invention relates to a novel compound useful as a TRPV4 antagonist, specifically the compound 1-(((5S,7R)-3-(5-cyclopropylpyrazin-2-yl)-7-hydroxy-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compound.The compound of the invention can be useful in the treatment of a disease state selected from: atherosclerosis, disorders related to vasogenic edema, postsurgical abdominal edema, ocular edema, cerebral edema, local and systemic edema, fluid retention, sepsis, hypertension, inflammation, bone related dysfunctions and congestive heart failure, pulmonary disorders, chronic obstructive pulmonary disorder, ventilator induced lung injury, high altitude induced pulmonary edema, acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, sinusitis/rhinitis, asthma, cough; including acute cough, sub-acute cough and chronic cough, pulmonary hypertension, overactive bladder, cystitis, pain, motor neuron disorders, genetic gain of function disorders, cardiovascular disease, renal dysfunction, stroke, glaucoma, retinopathy, endometriosis, pre-term labor, dermatitis, pruritus, pruritus in liver disease, diabetes, metabolic disorder, obesity, migraine, pancreatitis, tumor suppression, immunosuppression, osteoarthritis, crohn's disease, colitis, diarrhea, intestinal irregularity (hyperreactivity/hyporeactivity), fecal incontinence, irritable bowel syndrome (IBS), constipation, intestinal pain and cramping, celiac disease, lactose intolerance, and flatulence.

US Patent:

20200261411, Aug 20, 2020

Filed:

Feb 21, 2020

Appl. No.:

16/796989

Inventors:

- Brentford, GB
Carl A. BROOKS - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Guosen YE - Collegeville PA, US
Linda S. BARTON - Collegeville PA, US
Brian W. BUDZIK - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Jaclyn R. PATTERSON - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
Robert SANCHEZ - Collegeville PA, US
Matthew Robert SENDER - Collegeville PA, US
Lamont Roscoe TERRELL - Collegeville PA, US
David J. BEHM - Collegeville PA, US
James V. THOMAS - Collegeville PA, US

International Classification:

A61K 31/40
C07F 7/08
C07D 513/04
C07D 491/107
C07D 417/12
C07D 409/12
A61K 45/06
A61K 31/695
A61K 31/5386
A61K 31/506
A61K 31/501
A61K 31/4439
A61K 31/429
A61K 31/427
A61K 31/4245
A61K 31/424
A61K 31/4155
A61K 31/407
A61K 31/4025
A61K 9/48
A61K 9/20
A61K 9/00
C07D 498/10
C07D 207/48
C07D 413/12
C07D 401/12
C07D 403/12

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

US Patent:

20190216774, Jul 18, 2019

Filed:

Sep 20, 2017

Appl. No.:

16/334391

Inventors:

- Brentford, Middlesex, GB
Carl A. BROOKS - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Guosen YE - Collegeville PA, US
Lisa S. BARTON - Collegeville PA, US
Brian W. BUDZIK - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Jacyln R. PATTERSON - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
Robert SANCHEZ - Collegeville PA, US
Matthew Robert SENDER - Collegeville PA, US
Lamont Roscoe TERRELL - Collegeville PA, US
David J. BEHM - Collegeville PA, US
James V. THOMAS - Collegeville PA, US

International Classification:

A61K 31/40
A61K 9/00
A61K 45/06
C07D 207/48
C07D 413/12
A61K 31/4245
A61K 31/506
C07D 403/12
C07D 409/12
C07D 417/12
A61K 31/4025
A61K 31/427
A61K 31/4155
A61K 31/429
C07D 513/04
C07D 401/12
A61K 31/4439
A61K 31/501
A61K 31/407
C07D 491/107
C07F 7/08
A61K 31/695
A61K 31/5386
C07D 498/10
A61K 31/424
A61K 9/48
A61K 9/20

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

US Patent:

20190202784, Jul 4, 2019

Filed:

Sep 20, 2017

Appl. No.:

16/334410

Inventors:

- Brentford, Middlesex, GB
Carl A. BROOKS - Collegeville PA, US
Brian W. BUDZIK - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
John Jeffrey McATEE - Collegeville PA, US
Joseh E. PERO - Collegeville PA, US
David J. BEHM - Collegeville PA, US

International Classification:

C07D 207/48
C07D 401/12
A61K 31/4439
A61K 31/40
A61K 45/06
A61P 9/04
A61P 11/14

Abstract:

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Address:

1905 S Lynn St, Arlington, VA 22202

VIN:

JTHBJ46GX72070698

Make:

LEXUS

Model:

ES 350

Year:

2007