Caterina M Gallippi

US Patent:

20100138163, Jun 3, 2010

Filed:

Oct 28, 2009

Appl. No.:

12/607986

Inventors:

Caterina Gallippi - Cary NC, US
Olgha Davis - Apex NC, US
Elizabeth Loboa - Cary NC, US
Mansoor Haider - Apex NC, US

International Classification:

G06G 7/48
G06F 19/00
G01N 33/48

US Classification:

702 19, 703 7, 702 41

Abstract:

The subject matter described herein includes methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models. One aspect of the subject matter described herein includes a method for determining mechanical property parameters of a sample. The method includes applying acoustic energy to a sample to apply a mechanical force to the sample. The method further includes measuring a response by the sample during the application of the acoustic energy to determine a value for a first mechanical property parameter of the sample. The method further includes measuring a recovery response of the sample following cessation of the application of the acoustic energy to determine a value for at least one second mechanical property parameter of the sample. The method further includes determining a value for at least one additional mechanical property parameter of the sample based on a mathematical relationship between the first, at least one second, and at least one additional mechanical property parameter.

US Patent:

20130024136, Jan 24, 2013

Filed:

Aug 28, 2012

Appl. No.:

13/597011

Inventors:

Caterina Gallippi - Cary NC, US
Mallory Scola - Carrboro NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

G06F 19/00
G06G 7/48

US Classification:

702 41, 703 7

Abstract:

A method for evaluating mechanical properties of a sample includes applying a plurality of pulses of acoustic energy to a sample to apply a mechanical force to the sample and induce a non-steady-state displacement in the sample. The method further includes monitoring a response of the sample caused by the application of the mechanical force. The method further includes determining a quantitative value for a mechanical property of the sample based on the response.

US Patent:

8512697, Aug 20, 2013

Filed:

Apr 29, 2008

Appl. No.:

12/150562

Inventors:

Thomas H. Fischer - Hillsborough NC, US
Timothy C. Nichols - Chapel Hill NC, US
Caterina Maria Gallippi - Cary NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A01N 63/00
A01N 1/02

US Classification:

424 9372, 435 2, 977830, 977838

Abstract:

The invention is directed to platelets containing micron or nanometer size particles wherein the micron or nanometer sized particles comprises an active agent. The invention is also directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the above platelets. The invention is further directed to methods of delivering the micron or nanometer size particles containing an active agent to a site of interest in a patient.

US Patent:

20210023121, Jan 28, 2021

Filed:

Sep 14, 2020

Appl. No.:

17/019707

Inventors:

- Raleigh NC, US
- Chapel Hill NC, US
Yuqi Zhang - Raleigh NC, US
Caterina Gallippi - Cary NC, US

International Classification:

A61K 31/727
A61K 9/00
A61K 47/69
A61K 47/61
A61K 47/65
A61K 9/70
A61K 9/06

Abstract:

The present disclosure relates to a thrombin-responsive closed-loop patch for prolonged heparin delivery in a feedback-controlled manner. The microneedle-based patch can sense the activated thrombin and subsequently release heparin to prevent coagulation in the blood flow. The patch can be transcutaneously inserted into skin without drug leaking and can sustainably regulate blood coagulation in response to thrombin.

US Patent:

20180214476, Aug 2, 2018

Filed:

Feb 1, 2018

Appl. No.:

15/886152

Inventors:

- Raleigh NC, US
- Chapel Hill NC, US
Yuqi Zhang - Raleigh NC, US
Caterina Gallippi - Cary NC, US

International Classification:

A61K 31/727
A61K 9/00
A61K 9/70
A61K 47/61
A61K 47/65
A61K 47/69

Abstract:

The present disclosure relates to a thrombin-responsive closed-loop patch for prolonged heparin delivery in a feedback-controlled manner. The microneedle-based patch can sense the activated thrombin and subsequently release heparin to prevent coagulation in the blood flow. The patch can be transcutaneously inserted into skin without drug leaking and can sustainably regulate blood coagulation in response to thrombin.