Chad A Farrenburg

US Patent:

20030229213, Dec 11, 2003

Filed:

May 31, 2002

Appl. No.:

10/159313

Inventors:

Chad Farrenburg - Sikeston MO, US
Yi Xie - West Lafayette IN, US
Benjamin Hritzko - Groton CT, US

International Classification:

C07H017/08
B01D015/08

US Classification:

536/007500, 210/656000

Abstract:

The present invention comprises the optimization of a four zone simulated moving bed system configured to separate a first component from a mixture containing the first component and a second component wherein the first component exhibits non-linear adsorption and non-negligible mass transfer resistances. In one example, the four zone simulated moving bed is optimized to separate Clarithromycin from a mixture containing Clarithromycin and 6,11-O-methyl erythromycin A. The present invention further comprises a four zone or a five zone apparatus having a first portion and a second portion and the optimization of the four zone or five zone apparatus to separate a first component from a mixture containing the first component and a second component and the method of using the same. In one example, the four zone and five zone simulated moving beds are optimized to separate Clarithromycin from a mixture containing Clarithromycin and 6,11-O-methyl erythromycin A. The present invention further comprises a batch elution system configured to separate Clarithromycin from a mixture containing Clarithromycin and 6,11-O-methyl erythromycin A.

US Patent:

20220235095, Jul 28, 2022

Filed:

Jun 3, 2020

Appl. No.:

17/615254

Inventors:

- Rixensart, BE
Chad Austin FARRENBURG - Hamilton MT, US
Jeri Kay SANDVICK - Hamilton MT, US
Jeb Yeatts VANDENBURG - Hamilton MT, US

Assignee:

GLAXOSMITHKLINE BIOLOGICALS SA - Rixensart

International Classification:

C07J 63/00

Abstract:

Saponin extracts containing at least 88% QS-21 main peak and >3% to 10% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.

US Patent:

20200323980, Oct 15, 2020

Filed:

Nov 30, 2018

Appl. No.:

16/768416

Inventors:

- Rixensart, BE
Juan Jose DIAZ GARCIA - Marietta PA, US
Chad Austin FARRENBURG - Hamilton MT, US
Kent Raymond MYERS - Hamilton MT, US
Jeri Kay SANDVICK - Hamilton MT, US
Jeb Yeatts VANDENBURG - Hamilton MT, US

Assignee:

GLAXOSMITHKLINE BIOLOGICALS SA - Rixensart

International Classification:

A61K 39/39
A61K 36/185

Abstract:

Crude aqueous extracts of Molina containing at least the QS-21 main peak and 2018 component, wherein the ratio of 2018 component/QS-21 main peak is ≤0.075, as measured by UV absorbance at 214 nm, methods for obtaining such extracts and related aspects.

US Patent:

20200317719, Oct 8, 2020

Filed:

Nov 30, 2018

Appl. No.:

16/768402

Inventors:

- Rixensart, BE
Felicie Georgette, Colette DENET - Pompey NY, US
Juan Jose DIAZ GARCIA - Marietta PA, US
Chad Austin FARRENBURG - Hamilton MT, US
Lora Lea LAWRENCE - Hamilton MT, US
Kent Raymond MYERS - Hamilton MT, US
Jeri Kay SANDVICK - Hamilton MT, US
Jeb Yeatts VANDENBURG - Hamilton MT, US

Assignee:

GLAXOSMITHKLINE BIOLOGICALS SA - Rixensart

International Classification:

C07J 63/00
A61K 39/39
A61K 39/25
C12N 7/00
A61K 39/12

Abstract:

Saponin extracts containing at least 93% QS-21 main peak and 0.25-3% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.

US Patent:

20200102405, Apr 2, 2020

Filed:

Dec 21, 2016

Appl. No.:

16/063549

Inventors:

- Rixensart, BE
Chad FARRENBURG - Hamilton MT, US

Assignee:

GLAXOSMITHKLINE BIOLOGICALS, S.A. - Rixensart

International Classification:

C08B 37/00
C07H 11/04
B01D 11/04

Abstract:

A method of lipopolysaccharide (LPS) extraction from gram negative bacterial cells is provided, said method comprising a step of extracting LPS from the gram negative bacterial cell in a LPS extraction solution comprising a salt, water, an alcohol, and a further organic solvent. Compositions and uses of the extracted LPS are also provided.