Cheng M Liu

US Patent:

7399743, Jul 15, 2008

Filed:

Oct 24, 2002

Appl. No.:

10/279733

Inventors:

Cheng Liu - Carlsbad CA, US
Thomas S. Edgington - La Jolla CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/16
A61K 38/36

US Classification:

514 12

Abstract:

The invention provided compositions and methods to initiate site-specific thrombosis in tumor vasculature. The present invention also provides methods for using the disclosed compositions and methods to treat tumors.

US Patent:

7608591, Oct 27, 2009

Filed:

Nov 29, 2005

Appl. No.:

11/288978

Inventors:

Cheng Liu - Carlsbad CA, US
Thomas S. Edgington - La Jolla CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/00
A61K 38/14
C07K 9/00
A61K 38/04

US Classification:

514 18, 514 8, 514 17, 530322, 530330

Abstract:

The present invention relates to new agents and methods useful for preventing, treating and diagnosing diseases such as cancer. For example, the invention relates to prodrug agents useful for targeting and delivering cytotoxic drugs to cancerous cells.

US Patent:

20070264194, Nov 15, 2007

Filed:

Aug 9, 2002

Appl. No.:

10/486318

Inventors:

Cheng Liu - Carlsbad CA, US
Thomas Edgington - La Jolla CA, US
Margaret Prescott - Milburn NJ, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/08
A61K 38/00
A61K 49/00
A61P 9/00
C07H 21/00
C07K 1/00
G01N 33/53

US Classification:

424009200, 435007210, 514015000, 514016000, 514002000, 530300000, 530328000, 530329000, 536022100

Abstract:

The present invention provides peptides that selectively bind to mammalian atherosclerotic lesions. The present invention also provides methods for in vivo identification of peptides capable of binding to biomolecules as well as methods for identifying the targets of such binding moieties. Methods to diagnose or treat pathologic conditions that involve atherosclerotic lesions are also provided by the invention that involve administering to a mammal a peptide attached to a reporter molecule or a therapeutic agent, respectively.

US Patent:

20090175873, Jul 9, 2009

Filed:

May 29, 2008

Appl. No.:

12/156123

Inventors:

Cheng Liu - Carlsbad CA, US

Assignee:

The Scripps Research institute - La Jolla CA

International Classification:

A61K 39/395
C07K 7/06
C07K 16/00
A61K 38/08
A61P 35/00

US Classification:

4241391, 530329, 5303879, 514 17

Abstract:

The present invention relates to new compositions and methods useful for preventing, treating and diagnosing metastatic and/or invasive cancer and undesirable angiogenesis. For example, the invention relates to inhibitors of proteases that are specifically expressed in tumors, prodrugs activated in the tumor microenvironment and methods for using those inhibitors and prodrugs to inhibit angiogenesis and tumor cell invasion.

US Patent:

20100113328, May 6, 2010

Filed:

Oct 23, 2009

Appl. No.:

12/589572

Inventors:

Cheng Liu - Carlsbad CA, US
Thomas S. Edgington - La Jolla CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/02
C07K 4/10
C07K 5/00
C07K 5/06
C07K 5/08
C12N 5/00
C07K 5/10
A61P 35/00

US Classification:

514 2, 530300, 530322, 530330, 530331, 435410

Abstract:

The present invention relates to new agents and methods useful for preventing, treating and diagnosing diseases such as cancer. For example, the invention relates to prodrug agents useful for targeting and delivering cytotoxic drugs to cancerous cells.