Cheng Liu

US Patent:

6346101, Feb 12, 2002

Filed:

Jun 4, 1997

Appl. No.:

08/887196

Inventors:

Robert R. Alfano - Bronx NY
Cheng Hui Liu - Flushing NY

Assignee:

Research Foundation of City College of New York - New York NY

International Classification:

A61B 1818

US Classification:

606 15, 606 1, 606 10, 606 13, 606 17, 604 19, 604 20, 128898

Abstract:

A photon-mediated technique for introducing biological materials into cells and/or cellular components. The technique may be used to introduce nucleic acids, such as DNA and RNA, proteins or other biological materials into mammalian cells (as well as into other animal and plant cells), which materials may then flow into the nuclei of the cells. The technique uses picosecond or femtosecond light pulses propagating in the UV, visible and near infrared wavelength regions with powers on the order of 1Ã10 W/cm. In practice, the desired biological materials are coated on the end of the inner core of a single mode fiber or the ring core of a fiber in a fiber array. Each fiber is sized to correspond to one cell, with the core size ranging from 2 to 10, and the cladding ranging from 10 to 30. The laser pulse travels through a fiber core which is coated with the materials and ablates a portion of a targeted cell or cellular component membrane. In addition, as the laser pulse exits the fiber, it imparts energy and momentum to the materials applied to the end of the fiber.

US Patent:

8025879, Sep 27, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507044

Inventors:

Cheng Liu - Richmond CA, US
Jingyi Xiang - Walnut Creek CA, US
Su Yan - Albany CA, US
Pei Wang - Fremont CA, US
Wei Chan Tai - Emeryville CA, US

Assignee:

Eureka Therapeutics, Inc. - Emeryville CA

International Classification:

C07K 14/00
C07K 16/18

US Classification:

4241331, 5303873, 530395

Abstract:

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

US Patent:

8080415, Dec 20, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507046

Inventors:

Cheng Liu - Richmond CA, US
Jingyi Xiang - Walnut Creek CA, US
Su Yan - Albany CA, US
Pei Wang - Fremont CA, US
Wei Chan Tai - Emeryville CA, US

Assignee:

Eureka Therapeutics, Inc. - Emeryville CA

International Classification:

C12M 1/00

US Classification:

435334, 4352891, 435358

Abstract:

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

US Patent:

8084222, Dec 27, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507051

Inventors:

Cheng Liu - Richmond CA, US
Jingyi Xiang - Walnut Creek CA, US
Su Yan - Albany CA, US
Pei Wang - Fremont CA, US
Wei Chan Tai - Emeryville CA, US

Assignee:

Eureka Therapeutics, Inc. - Emeryville CA

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 721, 435 29

Abstract:

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

US Patent:

8295882, Oct 23, 2012

Filed:

Oct 18, 2010

Appl. No.:

12/906277

Inventors:

James Fan - San Ramon CA, US
Richard Kuo - Mountain View CA, US
Cheng P. Liu - Duluth GA, US

Assignee:

AT&T Intellectual Property I, LP - Atlanta GA

International Classification:

H04B 1/38

US Classification:

455558, 455415, 455418, 4554351

Abstract:

Systems, methods, and computer program products are for managing access to a femtocell coverage area. An exemplary method includes storing in a memory component a first identifier corresponding to a subscribed service of a communication device and a second identifier corresponding to a user of the communication device, and granting access to the femtocell coverage area using the second identifier.

US Patent:

20070225355, Sep 27, 2007

Filed:

Jun 23, 2005

Appl. No.:

11/571321

Inventors:

Cheng Liu - Richmond CA, US

Assignee:

Elixirin Corporation - Richmond CA

International Classification:

A61K 31/385
C07D 339/04
C12N 1/02
C12N 1/26

US Classification:

514440000, 435248000, 435261000, 549037000

Abstract:

This invention relates to dietary compositions and to methods for modifying cellular metabolism, metabolic production of reactive oxygen species and the resulting level of reactive oxygen species. The invention is drawn to a composition comprising a combination of carnitine, lipoic acid and polyphenol, which has the effect of enhancing metabolism and reducing oxygen species at the same time. When the composition is fed to older animals, the animals will have improved metabolism at the cellular level and a reduction of oxidative stress. The invention is also drawn to a method of oral administration of carnitine, lipoic acid and polyphenol to a mammalian host, at an effective dose necessary to affect enhanced metabolic processes and reduced oxygen species in animals including humans.

US Patent:

20090155821, Jun 18, 2009

Filed:

Jan 4, 2007

Appl. No.:

12/159827

Inventors:

John Kunich - San Leandro CA, US
Cheng Liu - Richmond CA, US

International Classification:

G01N 33/574
G01N 33/566

US Classification:

435 723, 435 72

Abstract:

Methods for detecting antibody dependent cellular cytotoxicity (ADCC) are described herein. The methods are label-free, and can be performed in real time on adherent cells. The methods can include, for example, (a) monitoring the impedance between electrodes on a non-conducting substrate that supports the growth of target cells in an assay medium; and (b) adding effector cells and an antibody that binds to the target cells to the assay medium; wherein any decrease in the impedance between the electrodes on the substrate following addition of the effector cells and the antibody is indicative of ADCC function having been effected in the assay medium.

US Patent:

20090246208, Oct 1, 2009

Filed:

Jan 4, 2007

Appl. No.:

12/159665

Inventors:

Michael Kavanaugh - Orinda CA, US
Cheng Liu - Richmond CA, US

Assignee:

Novartis AG - Basel
Xoma Technology Ltd. - Hamilton

International Classification:

A61K 39/395
A61P 19/00

US Classification:

4241581

Abstract:

Methods for preventing and treating osteolysis, cancer metastasis and bone loss associated with cancer metastasis by administering an M-CSF-antagonist in combination with a therapeutic agent to a subject are provided.