A photon-mediated technique for introducing biological materials into cells and/or cellular components. The technique may be used to introduce nucleic acids, such as DNA and RNA, proteins or other biological materials into mammalian cells (as well as into other animal and plant cells), which materials may then flow into the nuclei of the cells. The technique uses picosecond or femtosecond light pulses propagating in the UV, visible and near infrared wavelength regions with powers on the order of 1Ã10 W/cm. In practice, the desired biological materials are coated on the end of the inner core of a single mode fiber or the ring core of a fiber in a fiber array. Each fiber is sized to correspond to one cell, with the core size ranging from 2 to 10, and the cladding ranging from 10 to 30. The laser pulse travels through a fiber core which is coated with the materials and ablates a portion of a targeted cell or cellular component membrane. In addition, as the laser pulse exits the fiber, it imparts energy and momentum to the materials applied to the end of the fiber.
Method For Determining If A Tissue Is A Malignant Tumor Tissue, A Benign Tumor Tissue, Or A Normal Or Benign Tissue Using Raman Spectroscopy
Robert R. Alfano - Bronx NY Cheng H. Liu - Flushing NY Wenling S. Glassman - Bronx NY
International Classification:
A61B 600
US Classification:
128664
Abstract:
A method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue. The present method is based on the discovery that, when irradiated with a beam of infrared, monochromatic light, malignant tumor tissue, benign tumor tissue, and normal or benign tissue produce distinguishable Raman spectra. For human breast tissue, some salient differences in the respective Raman spectra are the presence of four Raman bands at a Raman shift of about 1078, 1300, 1445, and 1651 cm. sup. -1 for normal or benign tissue, the presence of three Raman bands at a Raman shift of about 1240, 1445, and 1659 cm. sup. -1 for benign tumor tissue, and the presence of two Raman bands at a Raman shift of about 1445 and 1651 cm. sup. -1 for malignant tumor tissue. In addition, it was discovered that for human breast tissue the ratio of intensities of the Raman bands at a Raman shift of about 1445 and 1659 cm. sup.
Method For Distinguishing Between Calcified Atherosclerotic Tissue And Fibrous Atherosclerotic Tissue Or Normal Cardiovascular Tissue Using Raman Spectroscopy
Robert R. Alfano - Bronx NY Cheng H. Liu - Flushing NY
International Classification:
A61B 600
US Classification:
128664
Abstract:
A method for distinguishing between calcified atherosclerotic tissue and either fibrous atherosclerotic tissue or normal cardiovascular tissue. The present method is based on the discovery that, when irradiated with a beam of monochromatic infrared light, calcified atherosclerotic human aortic tissue produces a Fourier Transform Raman spectrum which is distinguishable from analagous spectra obtained from fibrous atherosclerotic human aortic tissue and normal human aortic tissue. Some salient differences in the respective Raman spectra are the presence of five Raman bands at Raman shifts of 957, 1071, 1262-1300, 1445, and 1659 cm. sup. -1 (. +-. 4 cm. sup. -1 for all shifts) for the calcified tissue as compared to three Raman bands at Raman shifts of 1247-1270, 1453 and 1659 cm. sup. -1 (. +-. 4 cm. sup. -1 for all shifts) for the fibrous tissue and three Raman bands at Raman shifts of 1247-1270, 1449 and 1651 cm. sup. -1 (. +-. 4 cm. sup. -1 for all shifts) for the normal tissue.
Method And Apparatus For Evaluating The Composition Of An Oil Sample
Robert R. Alfano - Bronx NY Cheng H. Liu - Flushing NY
Assignee:
The Research Foundation of City College of New York
International Classification:
G01N 2164
US Classification:
250301
Abstract:
A method and apparatus for evaluating the composition of an oil sample. The method and apparatus are premised on the discovery that spectral differences can be observed in the luminescence, excitation, light scattering and absorption spectra in the near UV, visible and near IR regions for various crude oil components, such as asphaltenes, deasphalted crude oil and organic solid residues. Accordingly, in one preferred embodiment the method comprises illuminating an oil sample with light of a suitable excitation wavelength, measuring the resultant fluorescence therefrom and comparing the resultant fluorescence to appropriate standards derived from known components of crude oil.
Technique For Determining Whether A Cell Is Malignant As Opposed To Non-Malignant Using Extrinsic Fluorescence Spectroscopy
Robert R. Alfano - Bronx NY Cheng H. Liu - Flushing NY Wei L. Sha - New York NY Yury Budansky - Oakland NJ
International Classification:
G01N 2164 G01N 3352
US Classification:
436 63
Abstract:
A technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy. The technique is premised on the principle that certain fluorescent dyes preferentially stain malignant cells as opposed to non-malignant cells. Accordingly, by exposing a cell to the fluorescent dye, irradiating the cell with light of such a wavelength as to cause the dye to fluoresce, measuring the intensity of fluorescence at a wavelength indicative of fluorescence of the dye, and comparing the fluorescence intensity to standards obtained from malignant cells and non-malignant cells, it is possible for one to accurately classify the cell as being either malignant or non-malignant. The present invention also relates to an automated system which applies the principles of the aforementioned technique to depict the spatial distribution of cells within an area of a Pap smear-type sample and to characterize each of the cells as being malignant or non-malignant.
T Cell Receptor-Like Antibody Agents Specific For Ebv Latent Membrane Protein 2A Peptide Presented By Human Hla
- New York NY, US - Emeryville CA, US Andres Lopez-Albaitero - New York NY, US Cheng Liu - Emeryville CA, US Su Yan - State College PA, US Jingyi Xiang - Walnut Creek CA, US Hong Liu - El Sobrante CA, US
International Classification:
C07K 16/46 G01N 33/68 C07K 16/28 C07K 16/08
Abstract:
Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma.
T Cell Receptor-Like Antibody Agents Specific For Ebv Latent Membrane Protein 2A Peptide Presented By Human Hla
- New York NY, US - Emeryville CA, US Andres Lopez-Albaitero - New York NY, US Cheng Liu - Emeryville CA, US Su Yan - State College PA, US Jingyi Xiang - Walnut Creek CA, US Hong Liu - El Sobrante CA, US
International Classification:
C07K 16/46 C07K 16/08 C07K 16/28 G01N 33/68
Abstract:
Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma.
- New York NY, US - Emeryville CA, US Tao Dao - New York NY, US Su Yan - State College PA, US Cheng Liu - Oakland CA, US
International Classification:
C07K 16/32 C07K 16/28
Abstract:
Disclosed herein is a bi-specific form of a T cell receptor mimic (TCRm) mAb with reactivity to human immune effector cell antigen and a WT1 peptide/HLA-A epitope. This antibody selectively bound to leukemias and solid tumor cells expressing WT1 and HLA-A as well as activated resting human T cells to release interferon-(IFN-γ) and to kill the target cancer cells in vitro. Importantly, the antibody mediated autologous T cell proliferation and directed potent cytotoxicity against fresh ovarian cancer cells. Therapeutic activity in vivo of the antibody was demonstrated in NOD SCID SCID Yc* (NSG) mice with three different human cancers expressing WT1/HLA-A2 including disseminated Ph+ acute lymphocytic leukemia (ALL), disseminated acute myeloid leukemia, and peritoneal mesothelioma. In both of the leukemia xenograft models, mice that received the antibody and T cells also showed longer survival and delayed limb paralysis. Also provided are methods for stimulating a primary T cell response comprising stimulating cytotoxic T cells against a first tumor antigen and a secondary T cell response comprising stimulating effector T cells and/or memory T cells against a first tumor antigen and/or against a second tumor antigen using the bi-specific antibodies described herein.
Name / Title
Company / Classification
Phones & Addresses
Cheng Liu Principal
PC CLINICAL RESEARCH NY, INC Noncommercial Research Organization
50-77 Horatio Pkwy, Oakland Gardens, NY 11364 5077 Horatio Pkwy, Flushing, NY 11364
Cheng Liu
CARNATION UNISEX HAIR SALON SKIN CARE, INC
86-30 Broadway 2, Elmhurst, NY 11373
Cheng Yuan Liu
KANIA PRODUCTS INC
2311 Coney Is Ave, Brooklyn, NY 11223 2311 Coney Is Ave 2 Flr, Brooklyn, NY 11223
The Citco Group of Companies
Private Investments Valuation
Conversion Partners Mar 2012 - Jan 2014
Private Equity Associate
Level Group - New York Mar 2012 - Jan 2014
Real Estate Investment Broker
Mf Global Sep 2011 - Dec 2011
Associate Strategy and M and A
Merrill Lynch Jan 2009 - Sep 2009
Associate Equity Capital Markets
Education:
Cornell University 2011
Master of Business Administration, Masters
Cornell Johnson Graduate School of Management 2009 - 2011
Master of Business Administration, Masters, Finance
Baruch College 2004 - 2006
Master of Science, Masters, Accountancy
Binghamton University 1998 - 2002
Bachelors, Bachelor of Science, Economics
Benjamin N. Cardozo High School
Skills:
Financial Modeling Private Equity Financial Analysis Valuation Investments Bloomberg Finance Capital Markets Ipo Accounting Due Diligence Mergers and Acquisitions Equities Portfolio Management Peoplesoft Equity Derivatives Financial Reporting Fixed Income Microsoft Excel Hedge Funds Alternative Investments Microsoft Office Mandarin Hyperion Factset Dealogic Financial Accounting Real Estate Acquistions Equity Capital Markets
Interests:
Nfl Dessert Shop Madison Square Park Tower Piggyback Letterpress Fit By Saria Dentist and Dental Office Inc Community Jcmr Home Decor Food Insider Sports League Manny Pacquiao August Black Contractor Cornell Tech 260 Sample Sale Holidaypirates Real Estate King Kong Gc Inc Wander + Lust Tea Room Airfarewatchdog Ollie Gary Vaynerchuk Humans of New York Realtorjae The Little Model Tiffany's on Vine Organization Arts and Culture Precision Orthodontics Ice Cream Shop Base Nyc Bowery Crossfit Eater Ny Finny Thechef Compass Personal Blog Sporting Goods Store Notjessfashion Get Rxd Art of Light Lounge Calabarte Bar and Grill Education Performance and Event Venue Les Sports Bar Jewelry/Watches Dessert Kitchen Nyc Gym/Physical Fitness Center Clothing (Brand) Magnises The Cityfox Experience Entrepreneur The Kooples Chicken Joint Taft Chef Disaster and Humanitarian Relief Startups College and University Forbes News and Media Website Blogger I Feel Rolex Crain's New York Business Dessert Kitchen 糖潮 Tv Show Cornell University Remote Year Arnold Schwarzenegger Newspaper All Saints Suitsupply Company 愛挑剔手機3C配件 Pi Delta Psi Fraternity Curiositystream Kevin Durant Buzzfeed Video Too Many Zooz Business and Economy Website Iwc Schaffhausen Kevin Spacey Lucro Ferrari Maserati of Long Island Rurina Kato Time Out New York Barstool Sports Sportscenter New York Giants These Fine Walls Local and Travel Website Baker Program In Real Estate Retail Company Musician/Band Alternative and Holistic Health Service Babel The Brooklyn Mirage Song of Style Sports Team Entertainment Website Mark Cuban Investing Fields Good Chicken Travel Company Car Dealership Society and Culture Website Media The Boba Truck J&K Cabinetry Phoenix Phd Rooftop Lounge at Dream Downtown Shanghaiist Newmindspace Dance and Night Club Cabinet and Countertop Store App Page Nomnom Events Children Food and Beverage Company New York Arts and Humanities Website Nonprofit Organization Website Timecrafters Russell Westbrook Hodinkee Artist Product/Service Athlete Discount Store Spoiled Nyc New American Restaurant Urbandigs No Brokers Please Robert Downey Jr Real Estate Agent Racked The Modern Agent The Points Guy Ryan Serhant George Takei Community Organization Dan Bilzerian Public Figure Interior Design Studio Jonathan January Media/News Company Fsbo Consulting Service Animal Welfare Audemars Piguet
Director of Quantitative Analytics at MM Capital LLC
Location:
Greater New York City Area
Industry:
Investment Management
Work:
MM Capital LLC since May 2007
Director of Quantitative Analytics
BigTrends Financial Research Apr 2006 - Oct 2006
Research Analyst
University of Kentucky 2003 - 2006
Research Assistant
Education:
University of Kentucky 2002 - 2008
PhD ABD and Dual MS, Economics & Statistics
May 2011 to 2000 Business AnalystONGUARD FENCE SYSTEMS Branchburg, NJ Jan 2012 to Oct 2012 Account ManagerBLUE SKY TECHNOLOGIES Edison, NJ Aug 2010 to Aug 2011 Energy Specialist
Education:
NEW JERSEY INSTITUTE OF TECHNOLOGY Newark, NJ 2009 to 2011 MBASHAN DONG UNIVERSITY Jinan, CN 2005 to 2009 B.S. in Economics
Skills:
Data Analysis, Inventory Management, Logistics Coordination, Supply Chain Analysis, Budget Analysis, Financial Reporting, Marketing Research
A native New Yorker and Manhattan resident, Cheng has the local knowledge to help you with your real estate needs. Armed with an Ivy league MBA and a Investment banking background, Cheng has the financial knowledge to analyze your investment property with an analytical framework. As a resident and investor in Manhattan real estate, Cheng is tapped into the local real estate market with a discerning eye to spot long term trends as well as uncover undiscovered value. A quick conversation and you will be immediately impressed with his knowledge, professionalism, and honesty. Let Cheng be your guide in navigating the twists and turns of Manhattan real estate!