Chenghua C Liu

US Patent:

6465620, Oct 15, 2002

Filed:

Jun 21, 2000

Appl. No.:

09/602543

Inventors:

Bryan J. Boyle - San Francisco CA
Nancy K. Mize - Mountain View CA
Matthew C. Arterburn - Pleasanton CA
Y. Tom Tang - San Jose CA
John S. Tillinghast - Menlo Park CA
Ankura Sinku - Sunnyvale CA
Chenghua Liu - San Jose CA
Radoje T. Drmanac - Palo Alto CA

Assignee:

Hyseq, Inc. - Sunnyvale CA

International Classification:

C07K 100

US Classification:

530350, 530300, 435 6, 435 71, 435 691

Abstract:

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human von Willebrand/Thrombospondin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human fetal brain (Hyseq clone identification number 15258924). Other aspects of the invention include vectors containing processes for producing novel human von Willebrand/Thrombospondin-like polypeptides, and antibodies specific for such polypeptides.

US Patent:

6586390, Jul 1, 2003

Filed:

Jun 17, 2000

Appl. No.:

09/596196

Inventors:

Dana A. Haley - San Jose CA
Bryan J. Boyle - San Francisco CA
Alice S. Ho - Union City CA
Matthew C. Arterburn - Pleasanton CA
Y. Tom Tang - San Jose CA
Chenghua Liu - San Jose CA
Radoje T. Drmanac - Palo Alto CA
Nancy K. Mize - Mountain View CA

Assignee:

Hyseq, Inc. - Sunnyvale CA

International Classification:

A61K 3800

US Classification:

514 2, 424 941, 424 9464, 435183, 530350, 530381, 930 10

Abstract:

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human prothrombinase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human ovary (Hyseq clone identification number 7735656). Other aspects of the invention include vectors containing processes for producing novel human prothrombinase-like polypeptides, and antibodies specific for such polypeptides.

US Patent:

6635742, Oct 21, 2003

Filed:

Aug 31, 2000

Appl. No.:

09/653274

Inventors:

Bryan J. Boyle - San Francisco CA
George Yeung - Mountain View CA
Matthew C. Arterburn - Los Gatos CA
Nancy K. Mize - Mountain View CA
Y. Tom Tang - San Jose CA
Chenghua Liu - San Jose CA
Radoje T. Drmanac - Palo Alto CA

Assignee:

Nuvelo, Inc. - Sunnyvale CA

International Classification:

C07K 1600

US Classification:

5303871, 4352523, 4353201, 435325, 435 71, 536 231, 536 241, 4241301

Abstract:

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.

US Patent:

6743619, Jun 1, 2004

Filed:

Jan 30, 2001

Appl. No.:

09/774528

Inventors:

Y. Tom Tang - San Jose CA
Ping Zhou - Cupertino CA
Ryle Goodrich - San Jose CA
Chenghua Liu - San Jose CA
Vinod Asundi - Foster City CA
Feiyan Ren - Cupertino CA
Jie Zhang - Campbell CA
Qing A. Zhao - San Jose CA
Yonghong Yang - San Jose CA
Aidong J. Xue - Sunnyvale CA
Tom Wehrman - Stanford CA
Dunrui Wang - Poway CA
Radoje T. Drmanac - Palo Alto CA

Assignee:

Nuvelo - Sunnyvale CA

International Classification:

C12N 990

US Classification:

435233, 435234, 536 232

Abstract:

The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

US Patent:

6806254, Oct 19, 2004

Filed:

Jan 8, 2001

Appl. No.:

09/756247

Inventors:

Shubhada D. Godbole - Santa Clara CA
Bryan J. Boyle - San Francisco CA
Nancy K. Mize - Mountain View CA
Cenhua Deng - Cupertino CA
Ryle W. Goodrich - San Jose CA
Matthew C. Arterburn - Los Gatos CA
Ping Zhou - Cupertino CA
Y. Tom Tang - San Jose CA
Chenghua Liu - San Jose CA
George Yeung - Mountain View CA
Radoje T. Drmanac - Palo Alto CA

Assignee:

Nuvelo, Inc. - Sunnyvale CA

International Classification:

A61K 3800

US Classification:

514 12, 530350

Abstract:

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted alpha-2-macroglobulin-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal brain mRNA (Clontech) (SEQ ID NO: 1) and uterus mRNA (Clontech) (SEQ ID NO: 26). Other aspects of the invention include vectors containing processes for producing novel human secreted alpha-2-macroglobulin-like polypeptides, and antibodies specific for such polypeptides.

US Patent:

6818754, Nov 16, 2004

Filed:

Jun 12, 2003

Appl. No.:

10/461791

Inventors:

Bryan J. Boyle - San Francisco CA
George Yeung - Mountain View CA
Matthew C. Arterburn - Los Gatos CA
Nancy K. Mize - Mountain View CA
Y. Tom Tang - San Jose CA
Chenghua Liu - San Jose CA
Radoje T. Drmanac - Palo Alto CA

Assignee:

Nuvelo. Inc. - Sunnyvale CA

International Classification:

C12Q 168

US Classification:

536 231, 435 6, 536 241, 530300, 530350

Abstract:

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.

US Patent:

6846650, Jan 25, 2005

Filed:

Oct 25, 2001

Appl. No.:

10/002344

Inventors:

Herve E. Recipon - San Francisco CA, US
Yongming Sun - San Jose CA, US
Chenghua Liu - San Jose CA, US
Leah R. Turner - Sunnyvale CA, US

Assignee:

diaDexus, Inc. - South San Francisco CA

International Classification:

C12Q 168
C07H 2104

US Classification:

435 691, 536 235

Abstract:

The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.

US Patent:

6855517, Feb 15, 2005

Filed:

Nov 20, 2001

Appl. No.:

10/001887

Inventors:

Susana Salceda - San Jose CA, US
Roberto A. Macina - San Jose CA, US
Herve E. Recipon - San Francisco CA, US
Robert Cafferkey - San Jose CA, US
Yongming Sun - San Jose CA, US
Chenghua Liu - San Jose CA, US

Assignee:

diaDexus, Inc. - South San Francisco CA

International Classification:

C12Q001/68
C07H021/04

US Classification:

435 691, 536 235

Abstract:

The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.