Chengliang Liang Lu

US Patent:

20110280846, Nov 17, 2011

Filed:

Nov 2, 2009

Appl. No.:

13/127142

Inventors:

Fred J. Roisen - Prospect KY, US
Chengliang Lu - Louisville KY, US
Meng Wang - Louisville KY, US
Mengsheng Qiu - Louisville KY, US

International Classification:

A61K 35/30
A61P 25/00
A61P 25/16
C12N 5/10

US Classification:

424 9321, 435325

Abstract:

The presently disclosed subject matter provides recombinant dopaminergic neurons and/or recombinant progenitors thereof that include one or more transgenes encoding a nurr-1 polypeptide, a pitx3 polypeptide, an Imxi a polypeptide, a biologically active fragment thereof, a biologically active derivative thereof, and/or any combination thereof. Also provided are methods for producing a recombinant dopaminergic neuron or recombinant progenitor thereof, methods for producing lineage primed cells, methods for ameliorating at least one symptom associated with a neurological disorder, methods for transplantation, methods for inducing growth, repair, and/or regeneration of a neuron, for delivering a cytokine or a growth factor to the central nervous system, methods for providing a dopaminergic neuron function, and cell cultures that include recombinant olfactory epithelial-derived stem cells and/or a differentiated derivatives thereof.

US Patent:

20140308254, Oct 16, 2014

Filed:

Oct 26, 2012

Appl. No.:

14/354004

Inventors:

- Louisville KY, US
Chengliang Lu - Louisville KY, US

International Classification:

A61K 35/30

US Classification:

424 937

Abstract:

The present application describes the use of adult human olfactory neuroepithelium (ONe) stem cells in the treatment of diabetes.