Christopher R Cimarusti

US Patent:

20140057008, Feb 27, 2014

Filed:

Mar 1, 2012

Appl. No.:

14/002529

Inventors:

George Paffendorf - Hackettstown NJ, US
Christopher M. Cimarusti - Manalapan NJ, US

International Classification:

A61K 36/37

US Classification:

424759

Abstract:

Products derived from the Hook F (TwHF) plant in the form of extracts are provided that are useful in preventing, treating, or ameliorating a symptom of an inflammatory disorder or an immune disorder, such as an auto-immune disease. Also provided are methods of freeze-drying a TwHF root and/or root portion, methods of debarking a freeze-dried TwHF root and/or root portion, methods of preparing and/or refining extracts in freely flowable solid form from freeze-dried debarked TwHF roots and/or root portions, and methods of using freely flowable solid extracts of TwHF in preventing, treating or ameliorating a symptom of an inflammatory disorder and/or an immune disorder.

US Patent:

41137264, Sep 12, 1978

Filed:

Feb 28, 1974

Appl. No.:

5/446837

Inventors:

Frederic Peter Hauck - Somerville NJ
Christopher Michael Cimarusti - Somerset NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D29502
C07D29508
C07D29514

US Classification:

544380

Abstract:

Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n. sup. 1 is 0, 1 or 2 and n. sup. 2 is 0, 1, 2 or 3, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R. sub. 8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R. sub. 9 O(CH. sub. 2)q-. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

US Patent:

39717720, Jul 27, 1976

Filed:

May 19, 1975

Appl. No.:

5/578695

Inventors:

Christopher M. Cimarusti - Hamilton NJ
Seymour D. Levine - North Brunswick NJ
Frank L. Weisenborn - Titusville NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07J 500

US Classification:

26023955R

Abstract:

A series of novel steroidal [[16. alpha. ,17-b]1,4-dioxanes and steroidal [ 16. alpha. ,17-b]1,4-dioxins having useful anti-inflammatory properties is disclosed herein.

US Patent:

51946041, Mar 16, 1993

Filed:

Jun 29, 1990

Appl. No.:

7/546622

Inventors:

Theodor Denzel - Regensburg, DE
Christopher M. Cimarusti - Millstone NJ
Janak Singh - Lawrenceville NJ
Richard H. Mueller - Ringoes NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D41714
C07D50138

US Classification:

540222

Abstract:

Disclosed herein are processes for preparing a compound of the formula ##STR1## in which a novel compound of the formula ##STR2## is reacted with a beta lactam of the formula ##STR3## by treatment with a base, wherein the symbols are as defined in the specification.

US Patent:

40187608, Apr 19, 1977

Filed:

Feb 20, 1976

Appl. No.:

5/659863

Inventors:

Christopher M. Cimarusti - Hamilton NJ
Paul Wojtkowski - Wilmington DE
Joseph E. Dolfini - Cincinnati OH

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D50120

US Classification:

260243C

Abstract:

Thio-. beta. -lactam cephalosporins of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R. sub. 1 is hydrogen, lower alkyl, cycloalkyl, phenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic groups; R. sub. 2 is hydrogen, amino, carboxy, hydroxy or ureido; and X is hydrogen, hydroxy, lower alkylthio, lower alkylthiadiazolyl, lower alkyltetrazolyl or lower alkanoyloxy, are useful as antimicrobial agents.

US Patent:

40923185, May 30, 1978

Filed:

Mar 15, 1976

Appl. No.:

5/666983

Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D21122

US Classification:

26029356

Abstract:

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

US Patent:

40440400, Aug 23, 1977

Filed:

Mar 15, 1976

Appl. No.:

5/667003

Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C14368
C07C 3302
C07C 3532
C07C 3536

US Classification:

260456P

Abstract:

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

US Patent:

40912167, May 23, 1978

Filed:

May 16, 1977

Appl. No.:

5/797110

Inventors:

William A. Slusarchyk - Belle Mead NJ
Christopher M. Cimarusti - Hamilton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D50120

US Classification:

544 30

Abstract:

Cephalosporin intermediates of the formulas ##STR1## wherein R is lower alkyl, 2,2,2-trichloroethyl, diphenylmethyl, p-methoxybenzyl, or p-nitrobenzyl; R. sub. 1 is lower alkyl or phenyl; R. sub. 2 is hydrogen or acetoxy; R. sub. 4 is methyl or ethyl; and R. sub. 5 is hydrogen, methyl, or methoxy; are disclosed. Methods of reacting these intermediates to prepare antibacterially active cephalosporins are disclosed.